7UG6,1ZR9,6G90


Conserved Protein Domain Family
zf-C2H2_jaz

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pfam12171: zf-C2H2_jaz (This model is not part of the current CDD release)
Zinc-finger double-stranded RNA-binding
This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.
Statistics
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PSSM-Id: 520109
Aligned: 111 rows
Threshold Bit Score: 30.6074
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7UG6_I         48 QHYCIHCAKYMETAIALKTHLKGKVHK 74   Saccharomyces cerevisiae S288C
Q4E5J1         13 AFYCPSCNVYCSDSRTAALHRSSLKHK 39   Trypanosoma cruzi
Q9HA38        245 QFYCSMCNVGAGEEMEFRQHLESKQHK 271  human
XP_011615531  896 NFYCHLCGRHSNGDRQWEQHISSERHK 922 
Q8SWF6         55 HFYCCECDRHFITEKVLMEHKRSNPHR 81   Encephalitozoon cuniculi GB-M1
XP_006498341  604 RPFCTICNRYFKTPRKFVEHVKSQGHK 630 
Q7QEH9        212 TFRCETCQRVFIGEHQWQIHIHSKKHR 238  Anopheles gambiae str. PEST
Q54EG2        456 KYYCEHCSKELNGDNEWSFHQKSKQHR 482  Dictyostelium discoideum AX4
XP_001326756  267 KFYCEYCNRDLKTEERFKVHQTEKSHL 293 
Q5B9R2        112 RYYCKTCDRRFQNENNLQMHLNSQIHR 138  Aspergillus nidulans
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