6KG7,6BPZ


Conserved Protein Domain Family
Piezo_cap

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pfam12166: Piezo_cap (This model is not part of the current CDD release)
Piezo non-specific cation channel, cap domain
This is an extracellular domain at the C-terminus of Piezo, or FAM38 mechanosensitive non-specific cation channel proteins. Piezo is a family of proteins that form mechanosensitive non-specific cation channels whose conductance is higher for Li+, intermediate for Na+ and lowest for Li+. Divalent ions except for Mn2+ permeate the channel but more slowly than monovalent ions and can reduce K+ currents. These channels have a homotrimeric three-blade propeller-shaped structure that use a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Each protomer consists of 38 TM helices that form unusual non-planar blades, and an extracellular cap-like structure, the latter represented in this entry. This domain is embedded in the centre of the trimer and may control the transmembrane constriction site suggested to act as a transmembrane gate. This domain adopts a distinctive beta-sandwich fold.
Statistics
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PSSM-Id: 520106
Aligned: 67 rows
Threshold Bit Score: 167.492
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6KG7_A        2531 LKVMDNSKYNEFLKS---------FGPNSGAMQFLEn-yEREDVTVAELEGNSNSLWTISPPSKQKMIQEL--------- 2591 house mouse
Q4E330        2362 LPSLQHDEFGSQG-----------------------------LLQLLMFPRCSAEVWSATPETRLLLLSQLnaavnn--- 2409 Trypanosoma ...
Q4Q375        1485 DAAVRPFSFHAAATIs-------lGGASVGAAGLLRfaaVTGTWQTAHVASCSTRMWSYTPAALQELVDRLg-------- 1549 Leishmania m...
XP_001564414  1504 DSTVCPSSFHEAAALf-------gDGTVVRAEKLLRyaaATDTWQTAHVAPCSTRMWSYTPAALWELLDRLg-------- 1568
XP_001319509  1675 ILNLNDPMLDAFYs------------------------nNKKESQYFQYPDITLTNWQISDSSANYALNKM--------- 1721
XP_001582897  1673 VMTMNDKTLEPFFa------------------------nSRKESQYFTYPSITMTNWIISESSARFAMNTIk-------- 1720
XP_002499460  3765 ERYLMTSPLTQKF-----------------------------DAECLLFPRHSSVSWVLPAGPRGALATNLvthakwlnt 3815
25_pfamImport    1 -ELYSNSDSNSPS-------------------CEVDlntDSASTQCIEFGVFSNDAWGLSPPRMDLLVAQL--------- 51  
XP_067743168  2564 nQLYSNRDTNSPS-------------------CKVDlntDSASVQCVEFDVFSYDVWALSPPRTDLLVTQL--------- 2615
Q4Q184        2101 YDFFATTVRDNVTTPegwwtwierTRPTLGSYGFMA---EGKTVQLMEFTSCSSSLWMASPQAVRQVLAGLra------- 2170 Leishmania m...
6KG7_A        2592 -------TDPNSCFSVVFSWSIQRNMTLGAKAEia--tDKLSFPLAVATRNSIAKMIAGNDTES---------------- 2646 house mouse
Q4E330        2410 -ettffiHKEDHVVRMEVSAPATRRVC-----------SYQRYMVPWSTVVRLRDALEGAHLWYtsrhlekhqggvhsas 2477 Trypanosoma ...
Q4Q375        1550 --------KRTEVVTLLVRHRVTRNRASEAAMItv--gLEESYALPPTSQALLAEALNAWRTMDdadsagta------ey 1613 Leishmania m...
XP_001564414  1569 --------KTADAVTLVVRNRVTRDRASEPTRIav--dFEESYTLPPASQALLAEALKAWHAADsadsadtt------dy 1632
XP_001319509  1722 -----------TKFIPYVNFKFTTTSPTTKLTTdqitiTKTGNNLDEEQIKTLKEIINCTLNTQep-------------- 1776
XP_001582897  1721 -------NTSNPIFIPYVTFKFTVQTPTTKKNVdqitiTKNGKQLKPEVLETLYKALECTMNLAtp-------------- 1779
XP_002499460  3816 trqltstSTSESQAELVFTTAFTRYGPPTAKTVm----MEVISPLTSSQALEMGTMINDISDQ----------------- 3874
25_pfamImport   52 --------QSTKTLKWTITFTFTRPGPTNAEVIs----AKYSARMTDEHRIALIPMIKQTLTDGeg-------------- 105 
XP_067743168  2616 --------QSTQALNWTISFTFTRPGPTNDEVIs----ATYSVKMTDEHRNALIPMIKQTVSDNgg-------------- 2669
Q4Q184        2171 ------aASNASSAYMLQTLEVSRSVSSTDAAMaa--sLVNHWPIPQDTAQDLVAILERETSGArgaavvds------en 2236 Leishmania m...
6KG7_A        2647 ------SNtPVTIEKIYPYYVKAP-SDSNSKPIKQLLsen--nfMNITIILFRDNVTKsn---sEWWVLNltgs------ 2708 house mouse
Q4E330        2478 tlvyesGD-WIPLPQFYSPFVNNIqNDLVMKNYVR---------TDCAVQLNGVGNSDgktppvLYWCVRcnsfanltdg 2547 Trypanosoma ...
Q4Q375        1614 sasawdPI-EVPLPLLYSPYVLSYgTGVSFLSGATMRr------ANCSLTLHRTGRYR------GFSCVKcaeggqsspa 1680 Leishmania m...
XP_001564414  1633 laspwrTV-VVPLPSLYAPYVLSSgAGISFFSGLDVRg------VNCSLTLHRVGKYS------GFSCLTcaedgqrnta 1699
XP_001319509  1777 -----eNL-SLNIENLIPLYFTIPlSDEATFINKYYF--------NLSMQFMKSQSSGq-----FYWLISvnkte----- 1832
XP_001582897  1780 -----eNL-SFYLDDLVPLFFIIPlAKDASVVSNYYF--------NTTFTFEQSTNGN------FYWSIStkrta----- 1834
XP_002499460  3875 ------KA-EVAVERALPRLLNLPpRDQVIKLSKTAPdpnpsddATTILSLERLDDSL------MIWGLRtkqitlagvk 3941
25_pfamImport  106 ----ttLP-SVQIDDFFPAVVQLTaSRGVLKRSTQMH--------SLAVSKHSLNGST-------WWNIEpvvsss---- 161 
XP_067743168  2670 ----etLA-SIQVDNLFPAVLQLTaSSGVLQRSTKMR--------SVAITKHASDGST-------WWNIEpvasss---- 2725
Q4Q184        2237 ssssvvVG-SASLPFFYSPFVFNRaSRIDKLTTSLHFphr--nqHNCTLELNHGTDITlns-rvRYWCLRcaplfpegni 2312 Leishmania m...
6KG7_A        2709 ----------------------------------------------rifnQGSQALELVVFND-KVSPps--lgFLAGY- 2738 house mouse
Q4E330        2548 sttrtwsmnganepl-----------dmadsdndnvevmqsketlesgtdAGNITSIFEIVAS-SYVAlnpslvFLPNM- 2614 Trypanosoma ...
Q4Q375        1681 tatfaaat-------------------------tanpagssqiasgaeirEMSSPLTFVVASN-NVAIvqssfsLIPNV- 1733 Leishmania m...
XP_001564414  1700 kntlatda-------------------------ptspagsskiasaveidEKSTPLAFVIVSK-NVAVvqssfsLIPSV- 1752
XP_001319509  1833 ---------------------------------------------dmpdfVEEGALSSAVYCK-PSYNavi-gsLLTSTg 1865
XP_001582897  1835 ---------------------------------------------kqpvdVQEGPIGSVVFSK-PTYDavi-stLMSKTg 1867
XP_002499460  3942 k---------------------------------------gfcgmvdyteEGSQGVLYATMSD-RFLSgvveqlGLDSY- 3980
25_pfamImport  162 ---------------------------------------------gsnycSATYPFCIVAVSD-RIVQglt-tlGISSY- 193 
XP_067743168  2726 ---------------------------------------------gssycSATYPFCVVAVSD-RIVQglt-tlGISSY- 2757
Q4Q184        2313 psensssaaewrclttgegcddfnyedaaggsgsrtvqaslaaqmnsgvtAKQVSVYMVIISDtVVMGi----sLLKGI- 2387 Leishmania m...
6KG7_A        2739 -GIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRET------GELELEEDLYAKLIFLYRSPE 2811 house mouse
Q4E330        2615 -GIIALYTTFILAIGTFLRNTVMDRAHRVVLMQVANPDPIAELLRYIYMARSSaingyvDGLLLEQQLFFELVDMLRSPE 2693 Trypanosoma ...
Q4Q375        1734 -GIIALYTSFVLVMSSYIRNYFAGDAHRVVLLQLANPEPVTELLRYLYLARSSandgqvGDLALEQLLFVELLDLLRSPE 1812 Leishmania m...
XP_001564414  1753 -GIIALYTSFVLVMSSYIRNYFAGDAHRVVLLQLANPEPVAELLRYLYLARSSansgqvGDLVLEQLLFVELLDLLRSPE 1831
XP_001319509  1866 -GFYGLYVFIIFTCGTFVRSFITSFFQDLWIDRMGNPEIFLNVILAIEAHRNT------GDLPMEYATATMILNTARSLH 1938
XP_001582897  1868 gGFYGLYVFFTLSCGKMVRSFINSFFTDLWIDKMGKPEIFLNVILAIEAHRKA------GDLKSEYATAMMLLNTIRSVH 1941
XP_002499460  3981 -SMLALYAFIFVAIGGVVRRFFQFKIEDVMIYEIPNPDYLLRLCRGLRMLRAHry---pGCRRDEIKLFHTLIQMLRSPD 4056
25_pfamImport  194 -GLTAVYVFVVVTVGSAVKVFFRGKLFRIQYDELPDPGDVLELIEGIYIARHEqy---vGHLKDEVRLFEMLVRVLRSPE 269 
XP_067743168  2758 -GLTAVYVFVVVTVGSAVKGFFRGKLYQIQYEELPDPEDVLELVEGIYIARKEhy---vGHLKDEVRIFETLVRVLRSPE 2833
Q4Q184        2388 -GIVALYTTFVLALGRLLRSVLTNQTSTLLYSNMANPAALQNMVRCMEMAREY------GDLRLEHTIYLELVDLLRSAE 2460 Leishmania m...
6KG7_A        2812 TMIKWTRE 2819 house mouse
Q4E330        2694 RVLALSGR 2701 Trypanosoma cruzi
Q4Q375        1813 RLLRLSGR 1820 Leishmania major
XP_001564414  1832 RLLRLGGR 1839
XP_001319509  1939 NMAKIGKT 1946
XP_001582897  1942 NLVKIGGT 1949
XP_002499460  4057 ILIKVTRN 4064
25_pfamImport  270 TLIKVTGV 277 
XP_067743168  2834 TLIKVTGT 2841
Q4Q184        2461 RLFRVTGP 2468 Leishmania major
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