5FUR


Conserved Protein Domain Family
DUF3591

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pfam12157: DUF3591 (This model is not part of the current CDD release)
Protein of unknown function (DUF3591)
This domain is found in eukaryotes and is typically between 445 to 462 amino acids in length. Most members are annotated as being transcription initiation factor TFIID subunit 1, and this region is the conserved central portion of these proteins.
Statistics
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PSSM-Id: 520100
Aligned: 81 rows
Threshold Bit Score: 423.886
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5FUR_G        586 WNLSNDEYYYPK----Q---QGLRGTf-GGNIIQHSIPAVELRQpfFPTHMGPIKLRQFHRPPLKKYSFGalsq------ 651  human
XP_004355271  657 FNLSNDKYY--RqgvnR---SRVRQQs-GKALVQHSLPAIKLCL--TKTHFTLDDLESYHRPRIQFPPQHtf-------- 720 
XP_003290603  608 FNLSNDKFYKPVkk-----sNAVQQNa-GKATIQHSLPGIKLSL--VKTHLTKEDLIYAHRPRLLFPSNVlf-------- 671 
XP_020430576  722 FNLSNDKFYKTLg------kGRVRQQs-GKMSIQHSLPAIKLSL--VKTHLSIEDLTHMHRPVIAFQAGHqf-------- 784 
1_pfamImport    1 FNISNDKFYSNRkssqQqlkSHSKKRagHGVKVLHSIPALKLQT--MKVKLSNKDLAYFHRPKALWHPHEnvvalkeqgt 78  
XP_001326171  295 LKFHCDEYYMSLtenfL-------SSr-PNLDIQHSDVATNL----YLIEPNPHDIETQHHPRLNTLQILgl-------- 354 
XP_001583472  336 ISFHSEKYYTRLkvakE---NRMHQAv------QHSDPALNL----VLIEPNLRDLENFHHPHVNTLPILgi-------- 394 
EFP03078      505 FNLSNDDYYVPKa--tS---KTLSN---NSLLIQHSTPATNIATqfFPTHPSAFRLRYWHRTPFTRRIVKhwqpnr---- 572 
XP_002112811  539 YNFSNDAYYSTKtnttG---GGVSNTl-GVRAVLHSTPSVQLNPklFPTHWTPYSLRNFHRPIFCRPNYGkhh------- 607 
Q54DH8        839 FNLSNDKFYRPVrkppP---RPPNGS--TKVVIQHSLPGIKLSL--VKTHLTKEDLIYAHRPRILFPSNVpfrii----- 906  Dictyostelium...
5FUR_G        652 ----------------------------------------------------------------pgpHSVQPLLKHIKKK 667  human
XP_004355271  721 ------------------------------------------------------------------rIALFHKEAHRDDR 734 
XP_003290603  672 ------------------------------------------------------------------kIALYNKEGAITSN 685 
XP_020430576  785 ------------------------------------------------------------------rIALYNKDRPDDKP 798 
1_pfamImport   79 llergsmkvvlkslggkgsklhvnaeetvlsvkgkatkkldfkpsepvkiiysgkeledekslaeqdVRPNSLLHLVRTR 158 
XP_001326171  355 -----------------------------------------------------------------plKITYDPKTHPSYS 369 
XP_001583472  395 -----------------------------------------------------------------tyTVTWKPDEIPDDD 409 
EFP03078      573 --------------------------------------------------------------fqqiqVRKHNPARHQQRV 590 
XP_002112811  608 ----------------------------------------------------------------kapFMIRSVTKRIRKK 623 
Q54DH8        907 --------------------------------------------------------------iynkeGSLSGDLSSSSNN 924  Dictyostelium...
5FUR_G        668 akmreqerQ--------ASGGG----------------EMFF----MRTPQDLTGKD-GDLILAEYSEENGPLMMQVGMA 718  human
XP_004355271  735 --------Gr-------TRVAD----------------PS------MKHKIDLSARE-GRVVFVEYLEQHPALLNNVGMG 776 
XP_003290603  686 --------EqlnsstsnLNGSVnglrtgggfdsfsgssSSSLsskkSLHKSDLSGRD-GRVVLVEYTEQNPPLLSNVGMG 756 
XP_020430576  799 --------K--------QRGSN----------------RADP----MKHKLDLSARE-GRVIFVEYMEQNPPLLSNVGMA 841 
1_pfamImport  159 --------IhllpkaqkLPGEN----------------KSLRppgaFKKKSDLSARD-GHVFLMEYCEERPLLLGNPGMG 213 
XP_001326171  370 --------Ne-------FDTVQ----------------ISPY----LRDFESLSGRNgRKLILLEHTSENPAFILNVGMA 414 
XP_001583472  410 ------------------PDAQ----------------ISPF----LKDLDDLSGRR-GGIIVVEHTVEYPQFITNVGMA 450 
EFP03078      591 --------QamregmrqSQGGG----------------EVFY----MREINDLSGKD-ENLVMIEYSEEHPVILSQPGMA 641 
XP_002112811  624 --------AkereraraASGGG----------------EIFF----MVNLEDLSATD-GEVMLLEYSEEHPPLIQAVGMA 674 
Q54DH8        925 --------LllnsstnsIMGGHnmrgsinggmmsssssSSSSsskkSLHKSDLSARD-GRLVLIEYTEQHPPLVSNVGMG 995  Dictyostelium...
5FUR_G        719 TKIKNYYKRKPGKDPGAP-----DCKY--GETVYC---HTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRT 788  human
XP_004355271  777 ARIRNFYRRKNASDA--P-----FLSFedGENVLLdtnDETPFLGDITPGRTIQALVSNLYKAPIFRHNPSPTDFLLIRS 849 
XP_003290603  757 MKIRNYYRKKSNHDSAK------DVEFedGELVVIdsnDDSPFLGDIYPGQAVQAVVNNLYKSPVYKHNSSNTDFLLVRS 830 
XP_020430576  842 TRVRNYYRRKNSDDDQFL-----TFDD--GETVMLdhnDESPFLGEINPGVPIQSMVNNLYKAPIAKHNPNPTDFLLIRS 914 
1_pfamImport  214 ARLCTYYQKVSPGDQAGThlrsgPNNL--GNVLTLdpaDKSPFLGDIKPGSTQSCLETNMYRAPVYPHKVSSTDYLLIRS 291 
XP_001326171  415 SRLITYYHQATAEDIPRS-----LIE---SDTHLIkpnQASPFLASIPKSTPIHTISCNMFDVPVAKHDVEPTDFLLIRD 486 
XP_001583472  451 STLVTFWHKAHANDNPR------TFD---QHIQILdpdHASPFIGEIPKNEPVQCLSCNMFNVPVAKHPVESTDFLLVRS 521 
EFP03078      642 SKMKNYFKRRQAND-TEP-----TFDY--GEMAFS---HQIPFLGQLQPGQSLQSIENNLYRAPIYLHKRQSTDFLLIRS 710 
XP_002112811  675 SRVKNYYRKKASKDTGPQ-----SPEI--GEMVMVn--NNSPFLGSLSHGQLLQAFENNLYRTPIYKHKMPDDLFLVIKN 745 
Q54DH8        996 LRIRNYYKKKNTHDTGPK-----DLNFedGELVMLdnnEESPFLGDINPGQTIQSVVNNLFKVPIHKHNSANTDFLLVKS 1070 Dictyostelium...
5FUR_G        789 RQg---YYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDrp--rRIRMEDIKK-AFPSHSESS 862  human
XP_004355271  850 RDgk-kWYIREMGTLYTAGQQMPEVEVPAPNSRSANMFLKNRLQAFIHRLFRKKKNvq--rRIRIQDVCN-AFPSQSEAS 925 
XP_003290603  831 RDgk-rWYIRDLGPVYSAGQMLPEIEVPAPNSRSANMFLKSRLQAYIYRLFLKKSNsq--rRLKITDICS-SFPSQSETS 906 
XP_020430576  915 RDgk-kWYIREMGTMYTAGQMMPEIEVPAPNSRSANMFVKSRLQAYIYRLFLKKSNiq--rRLKISDVCT-AFPGQSETS 990 
1_pfamImport  292 AKg--kLSLRRIDRIYAVGQQEPHMEVMSPASKVLQTYNMNRLLVFMYREFRACQKrglapAIRANELSA-LFANVAEIP 368 
XP_001326171  487 MednrkFYIRHIDATYCASLLEARVKVMRPNKKVTQTFITNFITAILVNIFRGNKQykgrsRIQVSSVLKeFFPDMNELK 566 
XP_001583472  522 lde-pvFYLRNIDACYCAGLLEARTKVMRPGTKDAQKFNLNFIKAILINIFRGTKQypgrhHIQVQNVIKeFFPDVNEPK 600 
EFP03078      711 QNq---WFIRPIPAIFIAGQQCPLYEVPSPNSKRATVFVRDFLFAFIYRLFWASEHsp--rRLKMEDVRN-AFPHYAESN 784 
XP_002112811  746 HNg---YHIREAKWLHTGGQLCPKFEVPSPNSKKASNFVRDFLQVYIYRLFAKSTDnp--kRIKMDAIKK-SFTSHSESS 819 
Q54DH8       1071 RDgk-rWYIRDVGPIYAAGQILPEVEVPAPNSRNANMFLKSRLQAYIYRQFLKKSNpq--rRLKITDICS-AFPSQSETS 1146 Dictyostelium...
5FUR_G        863 IRKRLKLCADFKRTGMDSNWWVL--KSDFRLPTEEEIRAM-VSPEQCCAYYSMIAAEQRLKDAGYGEKsf---------f 930  human
XP_004355271  926 IRKRLKDCADLQRGGEDGGWWIL--KDSYRLPPEEEIQKS-VTPELVCTFESMLVGLYHLQANGIIHFtspgti-pmftq 1001
XP_003290603  907 IRKRLKDCADFQRGGDDSGWWTV--KDNFPLPTEEELQKL-VTPEVVCAYESMLIGLQRLQDNGIIHFtaqgtiptilgg 983 
XP_020430576  991 IRKRLKDCSDFQRGGDDSGWWTV--KDNFPLPTEEELQKL-VTPEVVCAYEAMLSGLQRIQDSGIIHFtnagtiptmlsn 1067
1_pfamImport  369 LRKRLKVFCDFQRGS-----WVM--KRNFRIPLEEELRRL-VTPEHVCAFESMLAGMYRLKRLGISMThpagls-aamnq 439 
XP_001326171  567 LREVLKKFAKNYRE-QGSGYWEPveKDLDAFFGT----IQ-ITPEDVCSYQSMQAGFKKLRRSGVNMLirskrv-yqqiq 639 
XP_001583472  601 LRNILKDFADFYRE-QGNGFWRI--KE--KINLDAEFQKIdITPEDVCSYQSMLVGHYHLKKSGVNILirskrv-yqqiq 674 
EFP03078      785 IRKRLKMCSTYTRNGADT-FWSL--KPEFRLPSKEEVLSM-VTPEMCCAQYSMMAAEQRLKDAGYGEKyf---------f 851 
XP_002112811  820 IRKRLKLCADFKRTGDHSNYWIL--KPDFRLPSEEELRDM-VTPEQACAYACMLAAEQKLKDAGYVGK------------ 884 
Q54DH8       1147 IRKRLKDCADFQRGGDDSGWWTV--KDNFTLPTEEEFQKL-VTPEAVVSFESMLIGLQRLQDNGIIHFtapgtiptilgn 1223 Dictyostelium...
5FUR_G        931 APEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGK----CLLEVTGVaDPTGCGEGFSYVKIPNKPtqQKDD-K----- 1000 human
XP_004355271 1002 RESADPNRDRYKLVEDELNRTPWNLTSSFTQAMQGK----GKMQLVSD-DPDNNET-FSYLKMPQKV--VNQK-Qkdlkk 1072
XP_003290603  984 LDEDDPIKKSYKPVEDELSITPWNLTGSFQAAMQGK----GRMQIISE-DPTAREDEFCYLKMPQKV--VNQK-Qkaikl 1055
XP_020430576 1068 LDENEPLRKKCKPVEDELNQTPWNLSASFVSAMQGK----GKLQLIGD-DP--RGEMFSFLKMPQKV--VNQK-Qkaikq 1137
1_pfamImport  440 LPDEAIALAAASHIERELQITPWNLSSNFVACTNQDrgnlERLEITGVgDPSGRGLGFSYVRTAPKApvSNAVaKkkvpi 519 
XP_001326171  640 NLKGELTKKVAEKIELELMKTPWARTENFTKAFDGQ-----LMEM------SRADTGEQIVRTKGRRgkSEAG-Eqk--- 704 
XP_001583472  675 KLEGELTKKVAARIEIELMKTPWARTENFVKAFEGQ----A-MQIQRTeD------GQQIMRSKSRRehDNSAgApq--- 740 
EFP03078      852 TPENDEGSDDEVTIEDEIKCAPWNTTRAFMASQREK----CLLDQTGIaDPTGCGQGFSYVRVSQKPh-KDEN-Atp--- 922 
XP_002112811  885 TVVEDEDNEDSQKIEDEVKTAPWNTTRAFLQALQGK----CQLSLTGDaDPTGCGEGFAYVRVPNKPv-VPKD-Esnv-- 956 
Q54DH8       1224 LDDEDPIKKSIKPVEDELSITPWNLTGSFLSAMQGK----GRLQIISD-DPTGREDEYSYLKMPQKV--VNQK-Qkaikl 1295 Dictyostelium...
5FUR_G       1001 --EpqpvKKTVTGTDAdlRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDV 1049 human
XP_004355271 1073 qlQ----KNQVTGTDAdlRKLSLKESETVLLKLGVSEEVINSLTRWKRIAL 1119
XP_003290603 1056 alQ----KNQVTGTDAdlRKLSLSASKTVLLELGVSEEKINSLTRWQRIDL 1102
XP_020430576 1138 alQ----KNQVTGTDAdlRKLSLKESKIVLLQLGVTEEVINNLTRWQRIAL 1184
1_pfamImport  520 nrG----GLTVTGTDAdlRRLSMKAAREVLMKFNVPEDQIAKLTRWHRIAM 566 
XP_001326171  705 -eP----KKQRYGTDAdlRVLHIPQLNEKLRSYGIPEEQIARLLRWDKVKL 750 
XP_001583472  741 paP----KKPLAGTKAdlRALTLRELRDKLVSLGVPTGEIERLSRWNQVAL 787 
EFP03078      923 -vP----KKLVTGTNAdlRKLPLKEAKQICRGYGVKEEEISALTRWEIIDV 968 
XP_002112811  957 inK----QRTVTGTDAdlRKLSLKNARQVLRDFGISDEEIKKLSRWEVIDV 1003
Q54DH8       1296 alQ----KNQVTGTDAdlRKLSLSASKTVLLELGVDEETINKLARWQRIDL 1342 Dictyostelium discoideum
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