Conserved Protein Domain Family
eIF_4G1
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pfam12152: eIF_4G1 (This model is not part of the current CDD release)
Eukaryotic translation initiation factor 4G1
This domain is found in eukaryotes, and is about 80 amino acids in length. It is found in association with pfam02854. This domain is part of the protein eIF_4G. It binds to eIF_4E by wrapping around its N terminal to form the eIF_4F complex. This complex binds various eIF_4E-BPs (binding proteins) to regulate initiation of translation.
Links
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Statistics
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PSSM-Id: 520098
Aligned: 48 rows
Threshold Bit Score: 61.5123
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6FVR4        439 PLAKQPADILTMTEFLAKLKEVEPVDDIYTFTYPPEFEEPDPKYKkQTVKYTYGPSFLLQFKEKARAFPD 508  [Candida] glabrata
XP_003959044  169 DEEVVEAEGVTVSEILQKLNEVQAIENIYDFKYPESFEAPDIRYKkEHIKYTYGPTFLLQFKDNFKAVPD 238 
XP_002552888  542 EDSDVDDGRITMTEFLARLDQVSPVDDIYSFKYPEGIEAPDARYKrEKAKYTYGPTFLLQFKDKVNVRPD 611 
Q6CXY2        474 EAEVEDDGKITMTDFLQKLKEVSPVDDIYSFQYPSDITPPNDRYKkTSIKYAYGPDFLYQFKEKVDVKYD 543  Kluyveromyces lactis
Q750J5        473 EVEEADDDRMTISELLEKLEKLPAVEDIYTFKYPESVQPPSDRFKkTSVKYTYPPEFLLQFGDKVNVKLD 542  Eremothecium gossypii
XP_001644843  326 STDVHDNNSMTVSNLLEILQRAKPIEDIYSFEYPKGFEKPDSKYSrSNIKYTYGPTFLLQFKDKIKVKPD 395 
XP_003673528  380 ADDVAEETHISMTDLLEKLKTAKPIDDVYSFSYPAELVQPEVKYQkKNVKYTYGPAFLLQFKDKIKVTPD 449 
XP_004179326  175 kqepLDDGSITYTTLLKFLENAKPIDDIFNFAYPQGIENPDVRYKkDHIKYTYGPAFLLQFKDKVNVTLD 244 
XP_001644035  292 KVDDESDTRMKMTDFLAILEKSKPIEDIYSFSYPAPIVGPDAKYKkQTVKYTYGPAFLLQFKEQVNIKPD 361 
XP_003687761  323 fVEDESDTRIRMTDFLSLLTNASNVQDIYAFEYSEDIERPDSRYKkEHIKYTYGPGFLLQFKDKVNVKPD 392
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