4GY5,4TVR,6VEE


Conserved Protein Domain Family
TTD

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pfam12148: TTD (This model is not part of the current CDD release)
Tandem tudor domain within UHRF1
TTD, tandem tudor domain within UHRF1 preferentially binds H3 histone tails trimethylated at Lys-9. It specifically recognises H3 tail peptides with the heterochromatin-associated modification state of trimethylated lysine 9 and unmodified lysine 4 (H3K4me0/K9me3). This domain is found in eukaryotes and is found in association with pfam00097, pfam02182, pfam00628, pfam00240.
Statistics
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PSSM-Id: 520095
Aligned: 31 rows
Threshold Bit Score: 191.694
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4GY5_A         9 LYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSR----------------------------------------------- 41  human
EDO40465     129 IYKKGEFIDAKDPSMGAWFEAEIVDISLKDESD----------------------------------------------- 161
XP_009017727 136 IYKVGDVLDVRDGTLGAWFEGGIVKVVSRACKNnnknnin-----------------------------------vvnnn 180
XP_032527455 168 PSNISEQSNTQKIGIAKYFTKQTNGKRLSKDFK----------------------------------------------- 200
EEZ98701     105 YYEIGDKIDVIDSDHGAWFEAKILGIFKPKETE----------------------------------------------- 137
4_pfamImport   3 LYKINELVDCRDVSIGAWFEASIENVTLTPTEInptkgkvgrppkrtnlkaegeqtqaqdlskdtrrtsavlntesngas 82 
1_pfamImport   3 LYKVNELVDVRDVNYGSWFEARIHSITRASDEHsrgktpl---------------------------------------- 42 
ELW69321     127 LYKVNELVDARDVGLGAWFEAHIHSVTRASDGHsrgktplkngnsykrtn----------------gnvnhnskentnkl 190
XP_009023456 135 LYKVGDVLDIRDVTLGAWFEGDLVKVVPRTRRInnnnsnnndisnsndsskdiglddkeskvsgmkedkmkkkdetnhgs 214
4TVR_A        19 IYKVNELVDARDVGLGAWFEAHIHSVTRASDGQ----------------------------------------------- 51  human
4GY5_A        42 --D-------------------------EPCSSTSRPALEED-VIYHVKYDDYPENGVVQM-NSRDVRARARTIIKWQDL 92  human
EDO40465     162 ---------------------------------------PES-VLYHVKYDGYEEDEINKL-PGRDIRPRARKRLQWDQL 200
XP_009017727 181 ikN-------------------------IDLNTEESKINDDD-------------SRDLTMvASRDLRPRSYRKISLTNL 222
XP_032527455 201 ---------------------------------VKTVKVTAEnVLYKVQLDDDEEDSELFC-KLKEIRPRARHEIDVKDL 246
EEZ98701     138 -------------------------------------NADEKdLTFRIKMDRNGNTAAFDV-TFSEIRPRAYYTYHKSEL 179
4_pfamImport  83 tsQ-------------------------TDASQTGNKGKEEN-VIYHIKYEDYPENGVVQM-GAIDVRPRARTLLRWDQL 135
1_pfamImport  43 -----------------------------kngssySVAADED-VIYHIEFDEYPESGIVKV-NLKDLRPRARTILKWNQL 91 
ELW69321     191 dnV-------------------------PSTSNSDSVAADED-VIYHIEYDEYPESGTLEM-NVKDLRPRARTILKWNEL 243
XP_009023456 215 krD-------------------------DDDDDDKNDGDDDDgYEYHVRYIGDDDSSDLTIvTSKDLRPRSYRKISLIDL 269
4TVR_A        52 --SrgktplkngnikhkskentnkldsvPSTSNSDCVAADED-VIYHIQYDEYPESGTLEM-NVKDLRPRARTILKWNEL 127 human
4GY5_A        93 EVGQVVMLNYNPDNPKERGFWYDAEISRKRE-TRTA----------RELYANVVLG--DDS----LNDCRIIFVDEVFKI 155 human
EDO40465     201 SVGQVVMANYCPDEPKERGFWYDVQITKKHSkQITQggaesrsgsgRELHAKLILSneEDShapvAQECRLIFLDEIFKI 280
XP_009017727 223 KINEKVMVNYNYDEPASRGYWYDAVITKIKD-TKSS----------KDVYATVYIGkdLVP----MENCKLPFVNEIFMI 287
XP_032527455 247 MPGQKVMINHNTDEPLEKGYWYDFKVDEIKK-LRTS----------YEIVGTLYLGpdSVP----QNDTKVKIHDKIFTI 311
EEZ98701     180 TPGVIVLANYNIEEPTSRGYWYDFEIKEI-----TK----------KGIKGALLVGteLAR----LENCTTQFVDELLRI 240
4_pfamImport 136 QVGMRVMVNYNMETPDERGFWFDGEIVTLNQtSRTN----------KELRVNILLGgaGDV----IPDCKIQFLDEIYQV 201
1_pfamImport  92 NIGDVVMVNYNAEIPSNRGHWFDAEITELKTiSRTK----------KELHATVFLGgsDGK----LNDCQIKFVNEIYKI 157
ELW69321     244 NVGDVVMVNYNVENPGQRGFWFDAEITTLKTiSRTK----------KELRVKIFLGgsEGT----LNDCRVIFVDEIFKI 309
XP_009023456 270 KVSEKVMVNYNYDEPADRGYWYDAVITEIKN-TKSS----------KDVYATIYIGkdLVP----MENCRLPFMNEIFVI 334
4TVR_A       128 NVGDVVMVNYNVESPGQRGFWFDAEITTLKTiSRTK----------KELRVKIFLGgsEGT----LNDCKIISVDEIFKI 193 human
4GY5_A       156 ERPG 159 human
EDO40465     281 EAPP 284
XP_009017727 288 ESPG 291
XP_032527455 312 EEPV 315
EEZ98701     241 ENPK 244
4_pfamImport 202 EKPG 205
1_pfamImport 158 EKPG 161
ELW69321     310 EKPG 313
XP_009023456 335 ESPG 338
4TVR_A       194 ERPG 197 human
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