Conserved Protein Domain Family
Hydrolase_4
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pfam12146: Hydrolase_4 (This model is not part of the current CDD release)
Serine aminopeptidase, S33
This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in Danio rerio mgll.
Links
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Statistics
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PSSM-Id: 520094
Aligned: 70 rows
Threshold Bit Score: 200.529
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_011948255  27 QDIKAIIQISHGMAETANRYEE-LASYLSEAGYIVYANDHRGHGKSAlsldqlGYLGEEDGFMSMVEDVHTLNTIIKEEN 105 Clostridium bot...
Q9LFQ7        54 RPPLGLIAVVHGFTGESSWFLQlTSVLFAKSGYLTCAIDHQGHGFSD------GLTAHIPNINLIVDDCISFFDDFRKRH 127 thale cress
O80628        33 REPRALVFLCHGYGMECSITMNsTARRLVKAGFAVYGMDYEGHGKSD------GLSAYISNFDRLVDDVSTHYTAICERE 106 thale cress
Q9C5I9        78 SKPRALVCFCHGYGDTCTFFFEgIARRLALSGYGVFAMDYPGFGLSE------GLHGYIPSFDLLVQDVIEHYSNIKANP 151 thale cress
Q9FVW6       117 DEIKAAVCFCHGYGSTCTFFFDgIAKQIAGFGYGVYAIDHPGFGLSD------GLHGHIPSFDDLADNAIEQFTKMKGRS 190 thale cress
Q9A6L0        59 GEPDWVVVGLHGMNDYANAYHL-AAAWWAGRGIATYALDVRGFGRS-------PARGVWAQPELVIEDVRLLVEAVRERH 130 Caulobacter vib...
Q2VZF7        59 AAPKAVIVAAHGMNDYSNAFDG-PGKGLAAQGIAVYAYDQRGFGQA-------PHPGWWSSTETMAADLRTVSRLLAARH 130 Magnetospirillu...
WP_024081267  55 GEIRAVVLALHGMNDYSQFFAE-PAAHLARHGILSYAYDQRGFGQG-------PHPRFWSSTDTMVADARAATDLLASRH 126 Magnetospirillu...
Q2RYC2        66 GPVRAEILALHGFNDYSGAFET-AGPALAARGIAVHAYDQRGFGTA-------PGRGLWPGGDILVRDAREAIATLHARH 137 Rhodospirillum ...
Q60A38        64 TRPKAVVVAVHGFNDYSLAFEP-LGSYLKTQGIGCYAYDQRGFGLA-------PGRGLWAGVDAYTEDLETFVGQVRTRH 135 Methylococcus c...

WP_011948255 106 KGL--PvFLLGHSMGSFISQRYI--QLYGQELN-GVILVGTNGNQGplinmGILVAKLEMKFKGRRHKSNLLnnlsfggy 180 Clostridium bot...
Q9LFQ7       128 ASSflPaFLYSESLGGAIALYIT--LRQKHQWN-GLILSGAMCSIShk-fkPPWPLQHLLTLAATLIPTWRVv------- 196 thale cress
O80628       107 ENKwkMrFMLGESMGGAVVLLLG--RKNPDFWD-GAILVAPMCKIAee-mkPSPFVISILTKLISIIPKWKIi------- 175 thale cress
Q9C5I9       152 EFSslPsFLFGQSMGGAVSLKIH--LKQPNAWA-GAVLLAPMCKIAdd-lvPPPVLKQILIGLANVLPKHKLv------- 220 thale cress
Q9FVW6       191 ELRnlPrFLLGQSMGGAVALKIH--LKEPQAWD-GLILVAPMCKISed-vkPPPLVLKTLILMSTLFPKAKLf------- 259 thale cress
Q9A6L0       131 PRA--KvALAGISMGGGLAISAMatPDPPR--VdKLMLFAPAVWGWs---nQPLPNKLSLWITAHAKGDWVVkp------ 197 Caulobacter vib...
Q2VZF7       131 GPA--PlYLLGESMGGAVVIEATvhAPPPE--VrGIILSAPAVWGRa---sMPWYQRAALWLSYKVAPGWTL-------- 195 Magnetospirillu...
WP_024081267 127 PGL--PfYVFGESMGGAVAMLAA--TEPPA-GMdGIILAAPAVWGRs---aMPWWQRLSLWLAYNVAPGWSP-------- 190 Magnetospirillu...
Q2RYC2       138 PER--PlYVLGESMGGAIAITALtgPEAPRDLVaGLVLSAPAVWGRd---tMPWSYRAALWLASRVVPGLRL-------- 204 Rhodospirillum ...
Q60A38       136 PGV--PvYLLGESMGGAVAIVAMtsARPPR--AdGLILSAPAVWSRd---tMPWYQSLLLAVSSHTIPWLRL-------- 200 Methylococcus c...

WP_011948255 181 nkkfePNRTEFDWLTRDEKEVDKYIKNEYC-GAIFPTSFYHDFLKGLKSIWKEENKNKipinLPIFIIAGDKDPVGNFGK 259 Clostridium bot...
Q9LFQ7       197 ----pTRGSIAGVSFKEPWKRKLAYANPNRtVGKPRAATAYELVRVCEDLQNRFEEVE----VPLMIVHGRDDVVCDPAS 268 thale cress
O80628       176 ----pSQ-DIIEISYKEPEIRKQVRENPLCsKGRPRLKTAYELLRISNDLEKRLQEVS----LPFLVLHGDDDKVTDKAV 246 thale cress
Q9C5I9       221 ----pQK-DLAEAGFRDIRKRDMTPYNMICySGKPRLRTAVEMLRTTQDIEKQLQEVS----LPILILHGEADTVTDPSV 291 thale cress
Q9FVW6       260 ----pKR-DLSDFFFRDLSKRKLCEYDVICyDDQTRLKTAVELLNATRDIEMQVDKVS----LPLLILHGDTDKVTDPTV 330 thale cress
Q9A6L0       198 ----pEWLVRNVMPSDNIDELRRMGRDPLM-IWGARSDTLYGLVGLMERAWRSPGAIS----TPVAWFYGANDHVIPRAP 268 Caulobacter vib...
Q2VZF7       196 -----TGRGLKIMPSDNIEMLRALSRDPLV-IKETRVDAIHGMVDLMDAAQRDAPRLD----LPLLLLYGAHDQIIPPEP 265 Magnetospirillu...
WP_024081267 191 -----SGHGLNIRPSDNVEMLRKLGADPLV-IKRTRIDAVKGVVDLMDQAEAAPAAIR----VPTLFLYGAHDEIIPSAP 260 Magnetospirillu...
Q2RYC2       205 -----SGKGLKRYPSDNLPLLYRIAEDPLW-IRATRTDAMRGVVDIMDQAYARAGALG----GPVLMLYGLNDQIIPAEP 274 Rhodospirillum ...
Q60A38       201 -----TGEGLGVMASDNIEMLRGLGRDPNV-IKATRVDAIHGLADLMDTAQERVPALK----TRTLVLYGERDEIIPRTP 270 Methylococcus c...

WP_011948255 260 GilnlYNFYKSIGVV--DVNYKLYKEGRHEIL-NEIN 293 Clostridium botulinum
Q9LFQ7       269 V----EELYRRCSSR--DKTIKIYPGMWHQLI-GESE 298 thale cress
O80628       247 S----QELYKVALSA--DKTLKLYPGMWHGLLtGETP 277 thale cress
Q9C5I9       292 S----RELYEKAKSP--DKKIVLYENAYHSLLeGEPD 322 thale cress
Q9FVW6       331 S----KFLHKHAVSQ--DKTLKLYPGGYHCILeGDTD 361 thale cress
Q9A6L0       269 T----VEAVSRLKS---GALTAYYPKGYHLLL-VDLQ 297 Caulobacter vibrioides
Q2VZF7       266 T----WDAVAALPHLgtRQRAALYANGWHMLL-RDLQ 297 Magnetospirillum magneticum AMB-1
WP_024081267 261 T----WQAAGAIP----SRRAAFYANGWHMLV-RDLQ 288 Magnetospirillum gryphiswaldense
Q2RYC2       275 I----REVARRLPGEppLQRLAVYPEGWHLLT-RDLQ 306 Rhodospirillum rubrum ATCC 11170
Q60A38       271 L----MALLDKLPA---GTRFAYYHRGYHLLL-RDLQ 299 Methylococcus capsulatus
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