8TQ2


Conserved Protein Domain Family
Med12-LCEWAV

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pfam12145: Med12-LCEWAV (This model is not part of the current CDD release)
Eukaryotic Mediator 12 subunit domain
This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. The function of this particular region of the Mediator subunit Med12 is not known, but there is a conserved sequence motif: LCEWAV, from which the name derives.
Statistics
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PSSM-Id: 520093
Aligned: 15 rows
Threshold Bit Score: 537.782
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8TQ2_C        286 EFVQSAYLSRRLAYFCTRRLALQ---------------------------------------------LDGVSSHSSHVI 320  human
XP_002430542  277 EFVQSELLSRRLSHLCCKKLGQLalrgglfpkedsssnlniqlssggnpmlgvvsannsgtlmngsrnCNNTNISVNSNS 356 
6_pfamImport    1 EFTQNELAARKLATVCVHRLALL---------------------------------------------CQGSASs----- 30  
EDO45182        4 QFVLSQTLAKSLAQVCTKKLSTLylaaeq---------------------------------mqseqpPNQATKPQTNNS 50  
2_pfamImport    1 EFVQSAYLSRRLAYFCARRLALL---------------------------------------------LSDSS--GLLTA 33  
Q8BQM9        283 EFVQSAYLSRRLAYFCARRLSLL---------------------------------------------LSDSP--NLLAA 315  house mouse
XP_002008745  399 DFVQSERLCRKMANLVAKKLAQL---------------------------------------------LNAAVEQQQQQQ 433 
Q2LZZ5        393 DFVQSERLCRKMAYIVSKKLAQL---------------------------------------------LNAAVEQQGIKd 427  Drosophila ps...
1_pfamImport    1 EFVQSELLSRRLAHLCCKKLGYM---------------------------------------------LNNVAENNLITs 35  
XP_015794700  295 DFTESELCSRKLAYQCAIKLNQLvssynsvs------------------------------slnssnnSNSSISSPGPND 344 
8TQ2_C        321 S-------------------------AQS---TSTLPTTPAPQPPTS-----STPSTP---------------------- 345  human
XP_002430542  357 NnndsninttnsgtlqtsgnymignsSNNqqmVSANVGQSTGNSVNNtvtviTTVQAAraiittittsiaiattiaaiva 436 
6_pfamImport   31 --------------------------SSA---TPAHGGVSPNSPNHNhtnanNSAAVT---------------------- 59  
EDO45182       51 Fpta--------------------lsTNG---SNDSSFTPVTSSSST--------STV---------------------- 77  
2_pfamImport   34 Hsphm------------------migPNN---ASIGAPSPGPPGPGV-----SPVQLA---------------------- 65  
Q8BQM9        316 Hsphm------------------iigTNN---TSIGTPSPGTPGPGM-----SPVQLA---------------------- 347  house mouse
XP_002008745  434 a-------------------------VIK---SQAMEIDGADEQLQQqqpniDPYEQA---------------------- 463 
Q2LZZ5        428 --------------------------VDG---GVGAGAGGGENKLQH-----DPFELA---------------------- 451  Drosophila ps...
1_pfamImport   36 pq----------------------seTKT---EQKDNEKEKKDVPVT-----NPMQST---------------------- 63  
XP_015794700  345 Ssss--------------------itNGQ---TVNRSGSPTTSPTSNsttsvEPLIIS---------------------- 379 
8TQ2_C        346 ------------FSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHyslTDSRIKT--------------GSPLDHLPI 399  human
XP_002430542  437 tttnsqiqvssyFNELMQCSHHRDVVIYLSTIIQVITLECPTALVWNc-iGEGRSTHpl-----------nNSPLDHLPC 504 
6_pfamImport   60 ------------FNEYLNCPHHKDVILALSVIIQVITLECPTALVWNs-lGEGKSTSvl-----------nGSPLDHLPC 115 
EDO45182       78 ------------LSQYKNCSQHNSLVLALGAIIQAVTICCPGALVWNstvCSSGQSSssnnsgdqtkpqvlGSPLDRLPM 145 
2_pfamImport   66 ------------FSDFLSCAQHGPLIYGLSCMLQTVTLCCPSALVWNystNDSKSVNp-------------GSPLDLLQV 120 
Q8BQM9        348 ------------FSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNystNENKISNp-------------GSPLDLLQV 402  house mouse
XP_002008745  464 ------------LHDYMNCPHHRDIILYLSTILQVITIECPTALVWSg-iAAHRAPSsl-----------vGSPLDHLPL 519 
Q2LZZ5        452 ------------LQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSg-iAAHRAPSsl-----------vGSPLDHLPL 507  Drosophila ps...
1_pfamImport   64 ------------LMEYQNCPHHRDIVLQLSTVIQTITLECPTALVWCg-tGVG---Svw-----------hGSPLDLLPM 116 
XP_015794700  380 ------------FRDLLSCPHHRNIAIGLSAIIQIITLKCPTAMVWH---GDGRLSPal-----------nGSPLDHLPC 433 
8TQ2_C        400 APSNLPMPEGNsaF--TQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGF-----TIGRVLHTLEVLDSHSFERSD 472  human
XP_002430542  505 PPSTLPMPARA--S--NSSLRQQIKQAEEAIKARSRAAEVRWSCDKWQQSTDGQ-----TTTKVLNALDSLDRHSFDKTD 575 
6_pfamImport  116 TPTALPMPQRN--A--NPHIRNQLRMAEEMIKQRSQAAENRWSCDKWQQTCAGV-----TKQRVLTALDALDRHSFYKVD 186 
EDO45182      146 APSALPMPGGGnnNpiNQEVMLSLLASEESVKTRGLAVESRWSPDKYQDKTSAVcfsviAVNRVLTTLEILDKYDFTRAD 225 
2_pfamImport  121 APSSLPMPGGNtaF--NQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGV-----TISRVLHTLEVLDRHCFDRTD 193 
Q8BQM9        403 APSSLPMPGGNtaF--NQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGV-----TISRVLHTLEVLDRHCFDRTD 475  house mouse
XP_002008745  520 APSVLPMPSRCprT--NHELRRQLRAAEAEIVLRTQHAEQRWFASKWLSAGKNH------YTTVLATLDHLDTHCFERMD 591 
Q2LZZ5        508 APSVLPMPTRCprT--NTEIRRQLRAAESEIVLRTQHAEQRWFASKWLSAGKNH------YTKVLATLDHLDTHCFDRME 579  Drosophila ps...
1_pfamImport  117 VPSSLPMAARC--D--MNTYRKQLQFAEHCIRERSKRAEGRWCTEKWQNSSAGT-----ITNRVLAALDALDRHRFDKMD 187 
XP_015794700  434 PPSVLPMPVRP--H--NRQLREELRVAEDEIRLRSRAVENKWCSDRSQQTAPGV-----IINRLLNTLDSLDCHSFEKVE 504 
8TQ2_C        473 FSNSLDSLCNRIFGLGPSK------DGh--E--------------------------------------I-----SSDDD 501  human
XP_002430542  576 SNNNLDTLYSKIFSNISTK------EGgnqSd-------------------------------------SrsdsaVIQEE 612 
6_pfamImport  187 TNNSLDTLYASIFPNPPEKpn----------------------------------------------------yqVEKDE 214 
EDO45182      226 NTNCIDLLYAKIFTSASKG-----------NrevnitcvfwylkllpphlinmlessssvsssninfslRitswlTSTDE 294 
2_pfamImport  194 SSNSL-----RRFIASSSEglrpefENhe---------------------------------------------vAPSDE 223 
Q8BQM9        476 SSNSMETLYHKIFWANQNK------DNqe---------------------------------------------vAPNDE 504  house mouse
XP_002008745  592 QCNSIDTLYANIFPPQSTQ-----------Lrrpeed--------------------------pqqqqqPrppyePKQDA 634 
Q2LZZ5        580 QCNSIDTLYVHIFP----------------Rrrdedqq------------------------dpqqqqqPrpvyePKQDK 619  Drosophila ps...
1_pfamImport  188 STNSLDTLYTKVFGGNSDQ-----------------------------------------------------------EN 208 
XP_015794700  505 PNNSIETLYSAIFKNQSSS------IVktdLseks-------------------------------lkkI-----IAEDE 542 
8TQ2_C        502 AVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERcgesEAADEKGSI------ASGsLSAPSA-P--IFQDVLLQ 572  human
XP_002430542  613 PIVEILCEWAVSNVRYGEHRAMAVAMLLEKRQAHLTGEG----GDCDDKDSI------SSG-NVVQNSlP--IFQGLLMK 679 
6_pfamImport  215 PIVNLLCWWAVSGVRYGEHRAIAVAKLLERRNNQVL-QEpessANGEDKDSV------NSV----APGlP--VFQPLLMK 281 
EDO45182      295 AIALLLCEWAISKHRVGKHRAFVVAKLLQRRQSDLLNKKddstSGGEESNSS------RHN----PIAtP--VCQKVLLE 362 
2_pfamImport  224 AVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERcgesEVLDEKESI------SSAsL-AGSSlP--VFQNVLLR 294 
Q8BQM9        505 AVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERcgesEVLDEKESI------SSAsL-AGSSlP--VFQNVLLR 575  house mouse
XP_002008745  635 DTVRILCEWAVSSQRWGEHRAIVVAILLDKRQIDVTSTPadqcGDKEDKDSL------ASG-AGIIDGlP--VFQHVLMH 705 
Q2LZZ5        620 DTVRILCEWAVSSQRWGEHRAMVVANLLDKRQIDVTSTPseqsSDKEDKDSL------ASG-AGLIDGlP--VFQHVLMH 690  Drosophila ps...
1_pfamImport  209 SVVKLLCEWAVSPERTGEHRALAVAALLDRRQSDSATNGdqetAPGDDKDSN------CSV----PGGpP--MFQQLLMK 276 
XP_015794700  543 PIIKLLCEWAVTTKRTGEHRALVVTKLLEKRQNELLAEKenekPEAKEMETNlpngckNSEaTSLINEtPhqIYQDLLMS 622 
8TQ2_C        573 FLDTQAPMLTD-PRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGA---------------PGPr---- 632  human
XP_002430542  680 FLDNDAPILEE-NGSIQNKVMFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLPTNSqttg-------gnynNKP----- 746 
6_pfamImport  282 FLDHDAPVLDEtNNSPANRTTFTNLVHLFSELVRHDVFSHDAYMCTLISRGDLLQINpqn---------gatTNPnstpg 352 
EDO45182      363 FLDNYAPVVESyQHSKGDPS-FAQLVLLFVELVRHDVFSHNAYLCTLISRGDLQPTPav-----------siPSPprqig 430 
2_pfamImport  295 FLDTQAPSLSD-PNSECEKAEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDL-SVTs-------------sTRP----- 354 
Q8BQM9        576 FLDTQAPALSD-PNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDL-SVTa-------------sTGL----- 635  house mouse
XP_002008745  706 FLDHDAPVLDEhNSSPQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLESml------------vHKTtakss 773 
Q2LZZ5        691 FLDHDAPVLDDhLSSAQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLSLEsv------------lASKastta 758  Drosophila ps...
1_pfamImport  277 FLDSDAPVPAP-DDCPQKKTAFSNLVHLFAELIRRDVFSHDAYMCTLISRGDLL-------------------GP----- 331 
XP_015794700  623 FLDTQAPVWDDkNPNPESKLAFSNLVLLFGELIRCDVFSHDAYMCALISRGQFANSPnasslippisdmkitNKSeqpsl 702 
8TQ2_C        633 ----PPSPFDDPADDPEHKEAEGSS--SSKLEDPGLSe--------------------------SMDIDp-sSSVLFEDM 679  human
XP_002430542  747 ----DTPNDGRVPPNSVDEEASLFP--RIDLKPPKME---------------------------GHDYD---DSKIDDDL 790 
6_pfamImport  353 rppnSNKSIETPTTQIHLDSDPTA---LFDLKPNKLQeh-----------------------grAMEYD---DSKIDDDL 403 
EDO45182      431 etplPLPVMSDIEECVQEGDAHGVP--GMDVPMSTHEd--------------------------VLRKDlssELELDREL 482 
2_pfamImport  355 -----RSPSGENADEHYPKDHDMKM--E----APGLSy--------------------------sKDFNmsvRLLLFVSK 397 
Q8BQM9        636 -----RSPAGENSDEHYSKDHDMKM--EIFSPMPGESc---------------------------ENINpslSRRLSVNG 681  house mouse
XP_002008745  774 ppppAPPPPNSSATTHGFDDDGFGSsiGIDFK--------------------------------HNEFD---DSNVDDDL 818 
Q2LZZ5        759 tkssPAAAATQATTTHGFDDDPFGG--GIDFK--------------------------------HNEFD---DSNVDDDL 801  Drosophila ps...
1_pfamImport  332 ------------EETTDVSTSHQSH--HTKLEDH--Sh--------------------------NMDFD---DATIDHDL 366 
XP_015794700  703 tnfvPNLPSATILPSLGGPTSNLVG--SIDVNTPNRSsesslpmfepvtdpsgstrsdlignweHLEMD---DAQLDSDL 777 
8TQ2_C        680 EKPdfslfspt--mpcegkgsPSPEKPDVEKEVK------PPPKEKieg----------------tlgVL---------- 725  human
XP_002430542  791 DKL------------------LQHIKEEQQNSMD------APDSPK----------------------DVgish---gvf 821 
6_pfamImport  404 DKL------------------LQTIKVEHQNSMD------APDSPKdvtgslvsg-----gighvtgmDTnsdphisadh 454 
EDO45182      483 -----------------------TLHQEQLERL----------------------------------------------- 492 
2_pfamImport  398 EKFsvskfkitlrcrgrgegdPQ--RTDIRKEVKparargsrg---------------------------------tlgr 442 
Q8BQM9        682 EKL---------------------LKREKPRELIfpsn------------------------------------------ 698  house mouse
XP_002008745  819 DKL------------------VQNIKEKGQQHE-------APDSPKigppgdgegg------------------vdtpat 855 
Q2LZZ5        802 DKL------------------VQNIKEKGQHD--------APDSPKigppgdgep--------------------stgga 835  Drosophila ps...
1_pfamImport  367 DKI------------------LQNIKEDQQNSMD------VPDSPKehdhghhphq---ssighvpmeTDhnd------h 413 
XP_015794700  778 GKL------------------LQHIKEGQQNNMNdqtdilLPDSVSsdkedeagsilanmgfgqqesgPK---------- 829 
8TQ2_C        726 -YDQPRHVQYATHFPIP-QEES-CSH--ECNQRLVVL 757  human
XP_002430542  822 cTQPSRHLLYTTHFPLP-QDEG-SSH--DCNQRHVLL 854 
6_pfamImport  455 rGKPSRHLLYSTHFPLP-QDES-CSH--ECNQRHVLL 487 
EDO45182      493 ------------------LDQGdAEGclDPDQAQSLH 511 
2_pfamImport  443 vynqKRNKGFTVHFSVF-QDES-SSH--ECNQRTVLL 475 
Q8BQM9        699 -ydlLRHLQYATHFPIP-LDES-SSH--ECNQRTILL 730  house mouse
XP_002008745  856 gvsiSRHYVYTKHFPIPqDDPSmSSYssESNQRYILL 892 
Q2LZZ5        836 ggsiSRHYVYTKHFPIP-QDE--SSYssESNQRYILL 869  Drosophila pseudoobscura
1_pfamImport  414 kVKPSRHLLYTTHFPLY-QDDPfSQH--DCNQRHVLL 447 
XP_015794700  830 -VHVQRHLLYTTHFPLP-QDET-TNH--DCNQRHVLL 861 
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