8TQ2


Conserved Protein Domain Family
Med12-PQL

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pfam12144: Med12-PQL (This model is not part of the current CDD release)
Eukaryotic Mediator 12 catenin-binding domain
This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. Both development and carcinogenesis are driven by signal transduction within the canonical Wnt/beta-catenin pathway through both programmed and unprogrammed changes in gene transcription. Beta-catenin physically and functionally targets this PQL (proline-, glutamine-, leucine-rich) region of the Med12 subunit of Mediator to activate transcription. The beta-catenin transactivation domain binds directly to isolated Med12 and intact Mediator both in vitro and in vivo, and Mediator is recruited to Wnt-responsive genes in a beta-catenin-dependent manner.
Statistics
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PSSM-Id: 520092
Aligned: 11 rows
Threshold Bit Score: 118.011
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8TQ2_C        1819 DLLHHPNPGSITHL-NYRQGSIgLYTQNQPLPA----GGPRVDP---YRPv-RLP-MQKL-PTRPTY--PgVL-PTTMTg 1884 human
2_pfamImport     1 ELMNMGQSGHTYRM-GYNQTSI-IYTQNQPLPP----GGPGLEPp--YRP--RMP-VNKM-PTRPNY--PgNYhPGGMG- 65  
4_pfamImport     1 QMMHHHQSALWGYNvMGQPPQTgFFVQNQPVPP----GMSGLVIk--SLLc-RRK-TFLLlQFLVFFlfFrVS-VEYIGs 71  
5_pfamImport     1 QMMQHPHSALWGYTiMGQPQQPgFFAQNQPLPP----GGSRLDPtssFVPanTKQaLSNMlQRRSVL--Q----PPSLHa 70  
1_pfamImport     1 EMLHGQQGHPFNRM-VYGPQSMgMYPQNQPLPP----GGPRLDTt--YRPt-RTL------PMRPNR--PaAY-PNMMTg 63  
9_pfamImport     1 DLLHHQTANSMSRL-AYGQSPVgLYAQNQPLPA----GGPRLDTs--YRPv-RMPqIGKLvPSRPPY--TgVL-PTSMSs 69  
10_pfamImport    1 ELMQNPT---YARTmPYNPQn--VYTQSQPLPPgqitGGPGLDAp--YRQptRNQ-IPKMmPARTNY--PtMM-PGMPGs 69  
6_pfamImport     1 EL--NP----YGRL-QYGQQAMnMYTQNQPLPP----GGPGLEPp--YRPt-RNPqMNKMmPTRPSY--PgMM-PSMQGs 63  
XP_005201865  1814 QVMHHPQSALWGYNlMGQPQQPgFFLQNQSVTP----GGSRLDPagsFVPtnTKQaLSNMlQRRSGA--M-MQ-PPSLHa 1885
XP_056665465  1798 DLLHHTSGSSISRF-GYPQTPVtLYTQNQPLPA----GGPRLDTt--YRPv-RMP-VPKI-QTRPSY--PgVL-SSPITg 1864 gray short-t...
XP_064422545  1787 DLLHHQPMHPYSRV-NYGQSSMgVYTQNQPLPA----GGPRLDAt--YRPsaRVP--MKI-SNRPPY--SgIM-PPVMPg 1853 coelacanth
8TQ2_C        1885 --------VMGLE-PSsYKTSvYR-QQqpavPQGQ--RLRQQLQqsqgmlGQs------SVHQMTPSSSYG-LQ-----T 1940 human
2_pfamImport    66 --------IMGMDnKQ-YTMG-FK-PQtamsQGQMlrQQIQSML------GQ-------QMRPMAPNQQYSsMQpaqniS 121 
4_pfamImport    72 --------EWKIFcLF-FIFIfLK-QGptidQAAIysQQARPSQlpq-ypGMq------QAQGKHSMPIYTgMCs---aI 131 
5_pfamImport    71 --------VTPQQ-QL-LQMKlLQ-QEq---QQRLlrHQAQARSlqqaaqGRa------LLEELEILSLFLlCTa---gM 127 
1_pfamImport    64 mpggvgnlITALDqQA-YRA--YK-PQpp-iQGQIlrQQLQAKLsqg-mlGQ-------QVRQMPPNPSYGtLQptqvpP 130 
9_pfamImport    70 --------MMSID-QA-YKSSvYRqQQppvpQGQLlrQQLQAKLqgqgmvGPq------PLRQMAPTPSYGaVQ-----P 128 
10_pfamImport   70 m-----pgIMGPD-KP-YQMT-FK-PHatmpQAPNlrQQLQVRLhqn-pnALg------QIRQMPPNQQYTsMQ-----T 128 
6_pfamImport    64 m-----tgMMGMD-KQ-YPMG-YK-PQpnivPGQTmrQHLQVRLnqs-maGQ-------QIRQITPNQPYTsMQas-qfA 125 
XP_005201865  1886 --------ITSQQ-QL-IQMKlLQ-QQ----QQQRllRQAQTRPfqqgqpGDqaalfaaQARPSPQLPQYPgLQqa-qtM 1949
XP_056665465  1865 --------VI-ID-PS-YKTPvYRqQQppvpQGQLlrQQLQAKLsqg-mlGQp------PVRQMNPNSSYGsLQ-----A 1921 gray short-t...
XP_064422545  1854 i-----ggIMSLDqQS-YKQGgYR-PQpppsQGQLlrQQLVAKLqnqamgSH---------RQMNPTSSYGsLQ-----A 1912 coelacanth
8TQ2_C        1941 S----QGYTPYVSHVGLQQH-TGPAGTMV-PPSYSSQPYQSTHpsTNPTLVDPTRHLqQRPSGYVHQQAP-TYGhgLTST 2013 human
2_pfamImport   122 Q----QGYTSYGSHMVMQPH-PSQTGAIV-PSQYGNQAFQGAHpgTNPGVVDPLRQM-PRPSGYVHQQASsAYG--MQNT 192 
4_pfamImport   132 P----HGYTMYSTQMSLQSQ---QSGGLVlSPAYSPRAYQVAH--SNPALMERLRQIqQQPSGYIHQQAA-AYLqpLTGN 201 
5_pfamImport   128 P----HGYTMYSTPMPLQQQ---QPGSVVlSPGYTPRAY-TAH--SSPVLMERLRPGq--PGGVAQQQAA-AYMqpLTGA 194 
1_pfamImport   131 P----QGYTSYGPHMGMQQH-PSQTGGMV-PPAYANQPFQGSHpaPNPAMVDSLRQMqQRPSGYIHQQAP-GYVhaMQNT 203 
9_pfamImport   129 S----QGYTPYVSHIGLQQH-PSQSGAMV-PPSYSSQTYQNAHpgSNPTFVDPTRTM-QRPSGYVHQQAP-GYVhsLSAA 200 
10_pfamImport  129 S----QGYTTYGSHMGMQQH-PSQSGSIV-PHSYGNQNFPGAHpgANPAVVDPLRQ--QRPSGYLLQQAP-GYPqsMQNT 199 
6_pfamImport   126 S----QGYTTYGSHMGMQQH-PSQGGGIV-PSSYGNQNFQGTHpgANPAVVDPLRQMqQRPSGYVHQQAP-GYAhnMQNT 198 
XP_005201865  1950 P----QGYTMYGTQMPLQQTpQQQAGSVVlSPTYNSRTYPAAH--SNPALMERLRQMqQPPSGYVQQQAS-PYLhpLTGS 2022
XP_056665465  1922 S----QGYTPYGSHIGLQQH-TGPAGTMV-PPSYSGQPYQSPHpaANPTLVDPTRHLqQRPSGYVHQQAP-GYGhgLPTT 1994 gray short-t...
XP_064422545  1913 PqnmsQGYTPYGSHLGLQQQ-LPQAAGMV-LPTYSGQAFp----gSNPALIDSVRQIqQRPSGYVHQQAP-GYShsLQNP 1985 coelacanth
8TQ2_C        2014 QRFSHQTLQ 2022 human
2_pfamImport   193 QRFAHQPMQ 201 
4_pfamImport   202 QRLSHQALQ 210 
5_pfamImport   195 QRLTHQPLQ 203 
1_pfamImport   204 PRFAHQQAS 212 
9_pfamImport   201 QRFPHQSMQ 209 
10_pfamImport  200 QRFPHQQLQ 208 
6_pfamImport   199 QRFAHQPMQ 207 
XP_005201865  2023 QRLNHQSLQ 2031
XP_056665465  1995 QRFTHQSLQ 2003 gray short-tailed opossum
XP_064422545  1986 QRFTHQPMQ 1994 coelacanth
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