Conserved Protein Domain Family
SLED

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pfam12140: SLED 
SLED domain
The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.
Statistics
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PSSM-Id: 403384
View PSSM: pfam12140
Aligned: 39 rows
Threshold Bit Score: 108.066
Threshold Setting Gi: 122119256
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009029412  347 TITVYVNPGCYCGPTLIPALIKsEMPSQFGPIPIRRGLQQILQCLMACSRDQQVIFNLLESGNgrvviqgrsfddcdwli 426  Helobdella ro...
XP_011489606  525 CSKIFVNHRCFSGPYLNKGRIA-ELPQAVGPGKCTLVLKEMLSMLVNSAYKPGRVLKELQELEdqswd---------cqe 594  Japanese medaka
XP_011682322 1383 idkVYYNHKCFSGPYLNKGRIA-ELPKSVGPGMVPLVLREVLHMLINAAYKPPRVLRELQVENeetagm-------ngsl 1454 purple sea ur...
EEN69607      491 cpkIYVNHKCFSGPYLNKGRIA-ELPRSVGPGSVVLVLKEVLTLLINAAYKPSRVLRELQVHGegred---------rhq 560  Florida lancelet
EKC24670      816 cpkIYYNHKCFSGPYLSKGRIA-SLPKCVGPGPVGLVMKEVLTNLINVAYKSFRVLKELQLEGkpnpk---------mqq 885  Pacific oyster
ESN98778      466 cSKIYFNTTCYSGPYLHKSRLN-VLPKSVGPGPVINVMITVLTKLIGCAYKSSRVLRELQLEGpaksn---------mhh 535  Helobdella ro...
EEC16391      496 cpCIFLNHRCFSGPFLSKGRLA-ELPRQIGPGPVALVLREVLSQIISVAYKSTRVLGELQLRGppdpk---------mqq 565  black-legged ...
EFX87706      466 cpkIYFNFRCFTGPLLSRIRVA-ALPRSVGPGPISLMMKEVLSLLLNGAYKPGSVLKQLQGEPndplpp-------gtql 537  common water ...
XP_001635138    6 KFAVYINKSCSTGPLLDPNKVA-SLTTSY-HGTLPVVIKEVMESLINCSYNKKEAFKCLPQGNgr--------------- 68   starlet sea a...
XP_009865344   46 CPQLYINHRCFSGPYLNKGRIA-ELPQSVGPGKCVLVLKEVLSMVINAAYKPGSVLRELQLVEdpqwn---------fqe 115  bar-tailed tr...
XP_009029412  427 gwLASNINGEVRQKQLKVIRKSATCHMFLNYLLTRLGCCSGLLTPT 472  Helobdella robusta
XP_011489606  595 etLKAKYKGKTYRSTIRTVRLAEQIPDFCQKVCLKLQCCPNLFSPA 640  Japanese medaka
XP_011682322 1455 hvMKAKYKGKSYRAMIELCKTASEVPSFLRNTCLNLECCPNLVSLH 1500 purple sea urchin
EEN69607      561 qqLKAKYMGKSYRAMVEMVRTSAEVDSYCKEICHKLECCPNLFGPL 606  Florida lancelet
EKC24670      886 qtIKAKYKGKSYRAVVEICRDINGLENFCRHICKKLECCPNLISPH 931  Pacific oyster
ESN98778      536 qvLRTRYKMKNYSATVDICMRSNQIDSYCRDVCRRLLCCPNLISTH 581  Helobdella robusta
EEC16391      566 qlLKAKYRGRTYRAVVETVRCSSQLEPFCRGVCAKLQCCPNLFGPR 611  black-legged tick
EFX87706      538 epLKAKYRQTTYRGTVPMASTAADVPEYCRWVCGKLQCCPYLFAPE 583  common water flea
XP_001635138   69 irISTCYEGKELGCFLRTVDRRAKFWQNIVEFLDELGCCENLVTEA 114  starlet sea anemone
XP_009865344  116 etLKAKYRGKTYRATVKIVRTSDQVADFCRRVCAKLECCPNLFSPV 161  bar-tailed trogon
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