Conserved Protein Domain Family
PML_CC
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pfam12126: PML_CC (This model is not part of the current CDD release)
PML-like, coiled-coil
This is the coiled-coil region of PML, also known as TRIM19. PML acts in association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, such as tumour, suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. PML is defined by the TRIM/RBCC motif which consists of an N-terminal RING zinc finger, two BBox type zinc fingers followed by a coiled-coil region. This coiled-coil region is thought to mediate interactions with cytomegalovirus IE1 protein and/or other partners. This entry also includes RNF207, which has a similar organisation.
Links
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Statistics
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PSSM-Id: 520081
Aligned: 16 rows
Threshold Bit Score: 412.667
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003462251 239 LDAMARALQEQEGAFQSVHTQVRSAISQLGHAREDTEEQIRAQVRQVVAHVQARERELLEAVQARYQRDYEGMAGRLGRL 318
XP_004855541 239 LDAMARSLQDQDGAFQAVRAEVRSAVSQLGQARADTEEKIHAHVRQVIAHVQARERELLQAVQAQYQRDYEGMARRLGRL 318
XP_005316841 239 LDTMAHALQEQDSTFSTAHAEMRSAIGQLGRARADTEELISTHVRQVVAHVLARERELLDAVNEQYQRDYQEMASQLRRL 318
EGW02110     191 LGTMTQALQEQDKTFDNAHAQMRSAIGQLEQARADTEELIRARVRQVVEHVQAQERELLEAVNARFQRDYQEISGQLGRL 270
NP_001298017 244 LGTMTQTLEEQGRTFDSAHAQMCSAIGQLDHARADIEKQIRARVRQVVDYVQAQERELLEAVNDRYQRDYQEIAGQLSCL 323
XP_051698211 237 LDATARALRERGGAFGAALAQVRAAIGQLGRARADAEDLIRERVRQVVAHVQAQERELLQQVHACYQRDYEELAARLSRL 316
ELW62488     217 LDGMTHALREQDGAFGAAHAQVHAAIDQLDQARRDTEELIRQGVRQLLAHVQAQERELLQAVEARYHRDRRELDSRMGRL 296
6_pfamImport   1 LDSMTQGLQEQDSAFGEVHAQMSAVVSQLGHRRSEMEALIRERVREVVKHVEAQERNLLEAVKERYERDYEEMARQLGSL 80 
5_pfamImport   1 LAAMTHALQEQESAFGAAHAQIRSALCQLDRARADTEELIRARVLQVVAHVKAREEELLESLKARYRSDSEEMTSRLGHL 80 
P29590       240 LDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRL 319 human

XP_003462251 319 DAVLQRIRVGGTLVQRMKSYASDQEMLDMHGFLREALCRLRQEEPQHLQAPVRTDSFDEIKVRLQDLISCIPQGTDTSLS 398
XP_004855541 319 DAVLQRIRVGGTLVQRMKRYASDQEMLEMHGFLREALCRLRQEEPQHLQAPVRTDSFDEVKVRLQDLMSCIPQGTDAALS 398
XP_005316841 319 DAVLQRIRTGGALVQRMKRYASDQEVLDMHDFVHKALNRLRQEEPQSLQAALHTDGFEEFKIRLQDFISCITQGTDAAVC 398
EGW02110     271 EAVLQRIRTGGELVKRMKLYASDQEVLDMHSFLHKALCRLRQEEPQNQKVQLRTSGFEEFKTCLQDFMSCITQRTDEAVA 350
NP_001298017 324 EAVLQRIRTSGALVKRMKLYASDQEVLDMHSFLRKALCSLRQEEPQNQKVQLLTRGFEEFKLCLQDFISCITQRINAAVA 403
XP_051698211 317 EAVLQRMRTGGALVRRMKHYASDQEVLDMHGFLHEALCRLRQEEPQGPQAAVRAEGFDEFKVRLQDLVARVTQATDAILS 396
ELW62488     297 DTVLQRIRTGSTLVERMKRYASDQEVLDMHSFLRQALCSLRQEEPQSLQAPVCTDGFKEFKARLQSLSSCVMEGKDAAPS 376
6_pfamImport  81 NTKLQRIRMGGMLVQKMRRFASDQEVMDMHGFLREALRRLCQEQPQTPQATVHTDSFDEFRARLEVLTSSITQGTDAVLC 160
5_pfamImport  81 DGVLQRIRMGGALVERMKRYASEQEVLDMHGFLREALHRLRQEEPQSLQAPVPTDGFNEFKVRLQDLISCTTEGTDAALP 160
P29590       320 DAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVS 399 human

XP_003462251 399 R-----------RVISEASGTPSDSSVSDQ---PSEA-QKA--QAL----ALGLSETQPAQMVQMVPRAYPVPIYAFSIR 457
XP_004855541 399 K-----------TASPEASSTPNDSSVTDQ---SNKA-PKA--QAQ----PLGLSEAQPAAVVHLVPRAHPMPIYAFSMR 457
XP_005316841 399 R-----------RASPETAGTPREPFDVDL---PDEA-QRV--QAQ----ALGLAEAQPVAVVQSVPGAHPVPLYAFSIK 457
EGW02110     351 R-----------RASPQPASTPRESSDLEQ---PNEV-QRE--LAQ----ALNMSETHSVAVVQSVPGAQPVPVYAFSMK 409
NP_001298017 404 SpeaasnqpeaaSTHPVTTSTP---EDLEQ---PKEV-QSV--QAQ----ALELSKTQPVAMVKTVPGAHPVPVYAFSMQ 470
XP_051698211 397 R-----------RTSPQSASTPGDLLHVDL---PEQA-QKM--QAP------------PMAVVQSVPGAHPVPLYVFSIR 447
ELW62488     377 R-----------RASPEAASTPRDPIDIDP---PEKV-QRV--QAQ----GQGPAEAQSVAVVQPVPGAHPVPVFAFSIK 435
6_pfamImport 161 N-----------RASPL-----RDASDDDL---PEEVpQRVqmQAQaeatALELAENQCMAVVQSVPGAHPKPMYAYSIK 221
5_pfamImport 161 K-----------RASPEAARTPRNSFDVDLldsPEEA-QRA--QAQ----VLGLSEAQPVAVVQQEPGAHPVPVYAFSIK 222
P29590       400 K-----------KASPEAASTPRDPIDVDL---PEEA-ERV--KAQv--qALGLAEAQPMAVVQSVPGAHPVPVYAFSIK 460 human

XP_003462251 458 SPSSG-EVSSAASPTKRKSCHTQCSRKIIKLESEEDTELPLAPSPSEQPRPSTSRAVSPPHLDRPAQP-ESPTMGKEALQ 535
XP_004855541 458 SPPSG-EVSNIVSPQKRKSSQTQCSRKIIKLESEEGKEVPMAPRPTEQPRPSTSRAVSPPHPDGPTQP-ESPTVGKEVLQ 535
XP_005316841 458 GSSYSeEVSNTTTPQKRKSCHTQCSRKVIKLESEEDKEARLASSSPEQARPSTSKAVSPPHSDGPPSP-ESPIIGKEVLL 536
EGW02110     410 SPTYReEASQTVTPRKRKCCHRNCSGKIIKVESTEENEDRLSTSSPEQPRPSTSKAISPRHVDGPANTdESPVLEEDTLL 489
NP_001298017 471 GPTYReEASQTVGSMKRKCSHEDCSRKIIKMESTEENEDRLATSSPEQSWPSTFKATSPPHLDGTSNP-ESTVPEKKILL 549
XP_051698211 448 DTSSAeEDSGTLVGRKRKSCYTQCPQKMIKLESEEKE--RPAQSSPEQPRPSTSKAVSPPQLDGTPSP-GSPNVGEEVDP 524
ELW62488     436 EPSCG-EISHTTTSQKRKSCQTQSPRKVIKMESEEEREARLARSPSVQPRPSTSKAVSPFRLDGPTSP-GHPTVGDEVSL 513
6_pfamImport 222 DSSYReEIPKIAVPQKRKSCQTECPRKVIKMESEEDKEAKLALNSSEQPRPSTSRAVSPPHLDGLPSP-KTPIKEADISS 300
5_pfamImport 223 DTSYGeEDSSPPRSQKRKSCQTEGPRKIIKMESEEEKEARLAQSFPEQPRPSTSKAVSPPRLDGSPSP-ESPVVGNEALL 301
P29590       461 GPSYGeDVSNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSP-RSPVIGSEVFL 539 human

XP_003462251 536 LNSTHVAT----EADEPIVVISSSEDSDAENS 563
XP_004855541 536 PNSTPVISga-aEADERIVVISSSEDSDAENS 566
XP_005316841 537 PNNNHVLGdt-gEAEERIVVISSSEDSDAENS 567
EGW02110     490 LTSNLVTSdt-gEAEEPIVVISSSEDSDTENL 520
NP_001298017 550 PNNNHVTSdt-gETEERVVVISSSEDSDTENL 580
XP_051698211 525 ANSNHVAGddpeEAEERVVVISSSEDSD---D 553
ELW62488     514 PSSNHLAStageEAEERIVVISSSEDSDVDNP 545
6_pfamImport 301 LNSSHGTDdi-eEAENCVFVISSSEDSDAEHS 331
5_pfamImport 302 PNSNHVTSep-gEAEERIVVISSSEDSDGEDS 332
P29590       540 PNSNHVASga-gEAEERVVVISSSEDSDAENS 570 human
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