Conserved Protein Domain Family
Rhomboid_N

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pfam12122: Rhomboid_N 
Cytoplasmic N-terminal domain of rhomboid serine protease
Rhomboid_N is the N-terminal cytoplasmic domain of the rhomboid intra-membraneous serine protease, otherwise known as Peptidase_S54, pfam01694. This N-terminal domain has similarity to other GlnB-like domains, some of which appear to have a binding role, eg to peptidoglycan. It is not clear exactly what the function of this domain is in the protease, but its presence is critical for maintaining a catalytically competent state for the protein.
Statistics
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PSSM-Id: 403371
View PSSM: pfam12122
Aligned: 20 rows
Threshold Bit Score: 90.4601
Threshold Setting Gi: 81362302
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q65QG8         1 MQLLFRSEIPSFAWQFRDYIRKKyqie-lilqQE-------KTDMRQNVIA---VYLSgNSEQTAAILQDLAEFHRNPFD 69  [Mannheimia] su...
Q15ZU2         4 PFLLVSFNQERAARLLINYLNSQ---------GIaaqyyvdKNDVNSAEHGv-qLLSEaDKDVASHIASE---FVQSPQD 70  Pseudoalteromon...
WP_011771702   1 MFLLHQFQNERAAQAFSDYLSAI---------GI-------KNNLHHDDFSy-qLLIE-QKEQQTQAEIELDLFLQHPND 62  Psychromonas in...
Q7MQ90         1 MQRLIVLNNPRMAQAFIDYMASR---------QI-------DLRMMPEGEGqfaLWLM-DDQHWVETEAELKQFLANPGD 63  Vibrio vulnific...
Q87KM6         1 MKRLVTLNNPRMAQAFIDYMASR---------QI-------DIEMMPEGEGqfaLWLT-DSQHEVEAEAELKQFLANPSA 63  Vibrio parahaem...
CAV20293       1 MIRLMVLDNPRLAQAFIDYMASR---------QI-------PIQMSPEGEGrfaLWLL-DGQFQVETEAELNRFLAEPNH 63  Vibrio tasmanie...
Q6LVS9         1 MHRLAGFHNPRQAQAFIDYMASR---------GI-------TLSLASEPEGvfaIWLV-DIEHQVEAESELNTFLSNPNE 63  Photobacterium ...
Q5E204         1 MQRLIALSNPRAGQAFIDYMASR---------HI-------DIRMMPEGDGqfaLWVVsDDAYLLEVESELQAFLRNPND 64  Aliivibrio fisc...
Q9KVP2         1 MHLLTTFNNPRAAQAFIDYMAAH---------HI-------EIQMMPDAGGqftLWVI-QDQHIETAQAELALFLENPYA 63  Vibrio cholerae
WP_012341147   1 MKLLFGSERENFIIWFRDYIRAKylleltiqnYI-------DEKYNRSVRG---VFIEeNHPLLTQLEQEKILFLQDPFN 70  Histophilus somni
Q65QG8        70 ERYERASWETGDVsSGSHSLKELA 93  [Mannheimia] succiniciproducens MBEL55E
Q15ZU2        71 EKYQQAAWDSGETvRLRDKNSGIS 94  Pseudoalteromonas atlantica T6c
WP_011771702  63 PKYMSASWQTGEVsSENNYFAFAD 86  Psychromonas ingrahamii
Q7MQ90        64 SKYSAASWDMAETrKTQFSYRSPS 87  Vibrio vulnificus YJ016
Q87KM6        64 SKYSAASWDVADTrKSQFHYASPS 87  Vibrio parahaemolyticus
CAV20293      64 KRYQAASWDMAETrKSNFHYHTPS 87  Vibrio tasmaniensis LGP32
Q6LVS9        64 SKYQAASWDVAESrTAKFNYRSPS 87  Photobacterium profundum
Q5E204        65 VKYQSASWDMADTrTAKFAYGSPN 88  Aliivibrio fischeri ES114
Q9KVP2        64 EKYQAASWEVADQkRPQFHYASPN 87  Vibrio cholerae
WP_012341147  71 PCYQQAAWEAGDT--HSIQYKKTS 92  Histophilus somni
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