Conserved Protein Domain Family
Salp15

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pfam12115: Salp15 
Salivary protein of 15kDa inhibits CD4+ T cell activation
This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.
Statistics
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PSSM-Id: 314916
Aligned: 44 rows
Threshold Bit Score: 57.3978
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5Q993   4 RSFFL----------VLVLAGLCFgetsedgvssggssgsGTEDKKVETQspegedssdgqsdsgtnretleLLNEKVPN 73  black-legged tick
Q709H2   4 LEVLIrpteqtaakaIAVGYTHTL----------------TWVWYSQTWD----------------------VDAVNDPV 45  Rice yellow mottle virus
Q4PMR1   3 LAFFM----------VILTLTYLS----------------CEVQSESNL-----------------------NIFGDMKY 33  black-legged tick
Q4PMT6   3 LALFL----------VVVAFTYVS----------------CDEESEPTP-----------------------DIFGEMEG 33  black-legged tick
Q4PNB0   3 LPLSV----------VLCATLDCI-------------------------------------------------------- 16  black-legged tick
Q4PN25   7 LPLSV----------VLLATLDYI------------------------------------------------HAAESLPR 28  black-legged tick
Q5Q990   7 LPLS-----------VVLLTGSVY------------------------------------------------IHAANPKE 27  black-legged tick
Q5Q999   3 QYFWI----------LCIGIRLSI----------------CGEQAISMYG----------------------YVDQTKGH 34  black-legged tick
Q4PMW5   2 KQIF-----------ILLVAVHLS----------------SQEDESPSVDpp------------------pvVIQKHYGR 36  black-legged tick
Q4PNB3   3 QQIFI----------LLAALQLSY----------------QEHESPSVHTpd-------------------eVIQEHYKR 37  black-legged tick
Q5Q993  74 FVGNYKKkkNLLLSFIASCGTNqmhvaslesktlvnkerttTSSSAINLVSVD--FPNCTFVC--------KPPNNGDTF 143 black-legged tick
Q709H2  46 LRADFNPdkVGWVSVSFACTQCtahyy---------tceqvKHFTNIPSVHYDvvCADCERGVqlddeidrEHQERNAEI 116 Rice yellow mottle virus
Q4PMR1  34 LPHDCKH--KLKEQIQNECSG-----------------------HTYQPLVIK--VTDCTYTCg------nEHENFFIQT 80  black-legged tick
Q4PMT6  34 LPGECKE--NLKKQIASECEG-----------------------NQYHPTPVE--FTGCQFKCg------yENDYIFVKL 80  black-legged tick
Q4PNB0  17 HATHCST--TLASYMNTRCSS--------------------SNFKFVG-------LSECSFTCq------gKNNKGQEQI 61  black-legged tick
Q4PN25  29 SQIADTCgrRLGDYISERC-------------------------LNLKTQLVT--FSGCSYTCq-------GKNAQGQNI 74  black-legged tick
Q5Q990  28 DADACSP--GLGDYIKRVC-------------------------SNSGTVLAS--FSECSYTCn---------AKKTNGL 69  black-legged tick
Q5Q999  35 MSDACEK--ALEERMQRRRQP--------------------PAFYPGNGHPTD--FKGCNFTCr--------MQSGPTTI 82  black-legged tick
Q4PMW5  37 LSPGCQT--EIQYQMKQVCKV--------------------HERSHFIPSLLG-----CFVYCy---------NDRSDGM 80  black-legged tick
Q4PNB3  38 LSPGCKT--EIKLQMEQICKV--------------------HDRFKFTPS-----YGGCFVYCy---------NNENDGM 81  black-legged tick
Q5Q993 144 RMN----MPKNTPCD---KFKNTCpgdgPCPT---Pp-----VPTC 174 black-legged tick
Q709H2 117 SACnaraLSEGRPASlvyLTRDAC----DIPE---H------SGRC 149 Rice yellow mottle virus
Q4PMR1  81 KTNqtfnMKDGTPCG----HSRVCvs-gVCVD------------TC 109 black-legged tick
Q4PMT6  81 TTRrtinLKDGTPCG----QNKVCik-gNCVY------------AC 109 black-legged tick
Q4PNB0  62 TRHn---LADGLPCG---PCKECCh--gVCRPvefGfgnpltFKSC 99  black-legged tick
Q4PN25  75 TTNh--yLMNGLPCG---DCKECCn--gACTSvkfGfgnpltFESC 113 black-legged tick
Q5Q990  70 TSWtkrnLPDGLPCG---KCRECCg--gSCTAvqfNlenpltVKSC 110 black-legged tick
Q5Q999  83 EQHv--nLTDGVPCG---PKGEKCkd-gLCVG---Gks--peLKNC 117 black-legged tick
Q4PMW5  81 RVP----LRNGLPCG---NYGQICkn-gECVN---A------PNNC 109 black-legged tick
Q4PNB3  82 RVT----LRNGLPCG---ENGQICkn-gKCVSt---------PNNC 110 black-legged tick
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