3GCM


Conserved Protein Domain Family
PNPase_C
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pfam12111: PNPase_C 
Polyribonucleotide phosphorylase C terminal
PNPase regulates the expression of small non-coding RNAs that control expression of outer-membrane proteins. The enzyme also affects complex processes, such as the tissue-invasive virulence of Salmonella enterica and the regulation of a virulence-factor secretion system in Yersinia. In Escherichia coli, PNPase is involved in the quality control of ribosomal RNA precursors and is required for growth following cold shock. This family contains the C terminal protomer domain of the PNPase core. The function of the C terminal protomer is to catalyze phosphorolysis through its two active sites.
Links
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Statistics
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PSSM-Id: 492378
Aligned: 12 rows
Threshold Bit Score: 35.1087
Created: 15-Feb-2025
Updated: 25-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3GCM_D          2 APRHSDWQRPTFAFEGKGAAGGHTATHHASAAPARPQ 38   Escherichia coli
Q8ZQ17       1028 TPHHSDWQRPSFHFEGKGAAGGHSATRHASAPATRPQ 1064 Salmonella enterica subsp. enterica serovar Typhimurium
Q7N378        995 PIVINEWQRPFSHFEGKGGAGGHSATNAATSPMAKPQ 1031 Photorhabdus laumondii subsp. laumondii
WP_012073566  924 PFDIVEWKDSRYYFHGKGSAGHHSAISHVFSEPTKAE 960  Actinobacillus succinogenes
Q9CM52        964 MCQIGVWTESRYYFHGKGSAGHHSAISHVYAGPTKAE 1000 Pasteurella multocida
P44443        897 DFPIRAWQDSRYYFYGKGAAGHHCAISHVYSEPTRTK 933  Haemophilus influenzae Rd KW20
WP_002440214 1048 APRHSDWVRPAFAFDGEGSAGGHSATHQASAPAGKPQ 1084 Shimwellia blattae
Q6D696       1054 PARHSDWVRPDYPFSGKGSAGGHSAVNQSTAPATKPA 1090 Pectobacterium atrosepticum
BAN98454     1037 PVRHSDWVRPAFNFKGRGSAGGHSATHQATAPATRPE 1073
WP_013318443 1028 APRVSDWQRPAFAFTGKGSAGGHSAENQASAPATRPv 1064 Dickeya dadantii
1_pfamImport    1 SPTKGHWERPTFDFSGKGSAGGHAAATQATAPATKPQ 37  
P21513       1022 APRHSDWQRPTFAFEGKGAAGGHTATHHASAAPARPQ 1058 Escherichia coli K-12
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