5A9Q


Conserved Protein Domain Family
Nup96

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pfam12110: Nup96 
Nuclear protein 96
Nup96 (often known by the name of its yeast homolog Nup145C) is part of the Nup84 heptameric complex in the nuclear pore complex. Nup96 complexes with Sec13 in the middle of the heptamer. The function of the heptamer is to coat the curvature of the nuclear pore complex between the inner and outer nuclear membranes. Nup96 is predicted to be an alpha helical solenoid. The interaction between Nup96 and Sec13 is the point of curvature in the heptameric complex.
Statistics
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PSSM-Id: 403363
View PSSM: pfam12110
Aligned: 124 rows
Threshold Bit Score: 143.116
Threshold Setting Gi: 298710918
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A9Q_5        453 AVFSYLTGKRISEACSLAQQSGDHRLALLLSQF------VG--SQSV-RELLTMQLVDWHQLQADSFIQDERLRIFALL- 522 
XP_001750473 2355 NVLRALLVHDLESAASLASSQKDHHLSLLIAQA------GG--ANKM-RSWLLNQLQDWQQRAADDFIHPLRLRIYAVL- 2424 Monosiga brev...
EGD80778     1535 QLLAHIHRHDLAAAVDLACQFKDHRLAMHLSQL------DE--GQRC-APLLRDQLVDWDERAASNRIHPLRRRVYALL- 1604 Salpingoeca r...
XP_001565807  616 ELVQAILCHRLREARTSARSVANEELARVVRVC------GE--GNQF-GGYVEMARSGFRNGEEVR------QRVVSLL- 679  Leishmania br...
1_pfamImport    1 -VLSLLCQHRIVEAADMAMDCGGWRLATLIAQA------ASyeGTDF-RRMMVKQMEEWNENGSLHCMDKSLVFVYSVL- 71  
XP_002901259 1576 GVLRLLCQHRVAEASEMALECGDFRLATLLAQA------ASyeGNAF-RNLMETQMAQWSENGSLEFMDKTLVLIYSIL- 1647 Phytophthora ...
3_pfamImport    2 GVLRLLCQHRIAEASDMAMDCGDFRLATLIAQA------ASyeGNDF-RSLMETQMAQWSENGTLELMDKTLVLVYSVL- 73  
XP_001420436  129 AALTHVAGGRTVSAARAAAAHGDPRLATCLAQI------GA--GKNV-AFYAKQQLTRWRAGSVGKYIDEFSEQAFKLL- 198  Ostreococcus ...
XP_002180245 1265 AIFAALAGGDVDKACIVAISSGLNNLAAILA------------SGSEgRKDVLLSVSKLAESNHASSVPAELIRLMKES- 1331 Phaeodactylum...
CBJ49271     1444 RVLELLSVRLVHDAAVAAMAAGLPRLAVMLTAVatqgggGGrpPARYgSKFLAQQAAQWQAAGADARMPQEAFSVVQLLg 1523 Ectocarpus si...
5A9Q_5        523 -----------------AGKPvwql----sekKQINVCS--QLD-------WKRSLAIHLWYLLPPTAS----------- 561 
XP_001750473 2425 -----------------AGAMiwpd----qaqTRLPTCQ--GLP-------WLAALAVHHWYAVSSTAT----------- 2463 Monosiga brev...
EGD80778     1605 -----------------AGCStwpdtphrhegNRIYTLE--GLT-------WKQTLTTFLTYLGPSS------------- 1645 Salpingoeca r...
XP_001565807  680 -----------------SGKVepfi---rdeeYTGLHDEaiEVRaaptaatWKQLLGIFTFYGCVSDTP----------- 728  Leishmania br...
1_pfamImport   72 -----------------SGSVevlsa-----------rqgaSMS-------WVTCLALFLWYKRGPALS----------- 105 
XP_002901259 1648 -----------------AGSVevlta-----------qkgfSMS-------WIACLALFLWYKRGPATS----------- 1681 Phytophthora ...
3_pfamImport   74 -----------------AGSIevlsa-----------qkgaSMS-------WIDCLALCLWYKRGPATS----------- 107 
XP_001420436  199 -----------------AGEV---------------ERDddGMG-------WYQNLGLHMWLAAGPTSP----------- 228  Ostreococcus ...
XP_002180245 1332 -----------------GGDVhsectl--------ykqgssSLD-------WKRRLALRLLQDSDKS------------- 1366 Phaeodactylum...
CBJ49271     1524 regfrdvglrgliskgpGGSLr------------------pSLD-------WMRQLGLCLWFGAGASAGiggedgdrdgg 1578 Ectocarpus si...
5A9Q_5        562 ----ISRALSMYEE-A--FQntsdSDRYA-----CS-----------PLPs-YLEGSGCVIAEEQNSQTPLr-------- 609 
XP_001750473 2464 ----VADSIRSYARsAfnLL----SGRSK------SgaavqtfeaaaPSPs-YLDPEALQAQQMLGMQKFDdasgmps-- 2526 Monosiga brev...
EGD80778     1646 ----LGAVLDTYEE-AtrVW----LTDQKggrviAR-----------PPVvaHQSHCVTLSSPNMRMWTRDapesrea-- 1703 Salpingoeca r...
XP_001565807  729 ----AEDIIHAFLE-R--LR----APSSRk----LN-----------PLPp-YAERVDTAVLRTCRGKDVVrrgn----- 776  Leishmania br...
1_pfamImport  106 ----LKSAVTLYEE-S--VS----KQLAS------P-----------PMSr-FAVAGTKKE------------------- 137 
XP_002901259 1682 ----LKSVMALYED-A--VR----KQLAS------T-----------PLSk-FAPVDTDKD------------------- 1713 Phytophthora ...
3_pfamImport  108 ----LKSAMALYEE-A--VG----KQLAS------V-----------SLSk-FAAAGTNKD------------------- 139 
XP_001420436  229 ----LRDVVKNYLD-A--VA----QQRAA------N-----------PLP----PVATYEALDANQATHLR--------- 267  Ostreococcus ...
XP_002180245 1367 ----LVQLLCQYEN-D--IS----SNHAP------P-----------PNLp-HSQQTDMR-------------------- 1397 Phaeodactylum...
CBJ49271     1579 gggvVANAIEAYDT-L--VA----DGEAL------S-----------PTAryFLEPTHHESAHLDKVCAELrrvympppp 1634 Ectocarpus si...
5A9Q_5        610 ---------------------DVCFHLLKLY----------SD-R-HYDLNQ--LLEPRSIt---ADPLDYRLSWHLWEV 651 
XP_001750473 2527 --------------snsdffgDLLFNIMQMF----------ACpS-NVNMER--ALLGRTVg---PDLDDLRLPCLAYLI 2576 Monosiga brev...
EGD80778     1704 ---------------trperqDLLYCLLRLK----------AY-G-GKDLAVkdLLNPLHHt---ADEHDYRLSWLLFVL 1753 Salpingoeca r...
XP_001565807  777 ------------------tfqDAALLVLEGF----------AN-G-SAPPAA--CLHPHASs---YSGTDYLTAFVIVTA 821  Leishmania br...
1_pfamImport  138 ---------------------DVLMELMKLY----------IE-D-VASLCK--VLSPSGYmtqgLFHLDYELSWHLHSV 182 
XP_002901259 1714 ---------------------DVLMELMKLY----------IE-D-AASLCK--VLSPSGFmsqgTHHLDYELSWHLHSF 1758 Phytophthora ...
3_pfamImport  140 ---------------------DLLMELMKLY----------IE-D-VSSLCK--VLSPSGFmshgSRHLDYELSWHLHSV 184 
XP_001420436  268 ---------------------DVAFNILALAastedeggspS----TAEVRV--AFHPLTYs---DDVLNASLAWHLFGV 317  Ostreococcus ...
XP_002180245 1398 ---------------------SLTFQLLKSY----------SV-PqSMEVSD--VVHPLGFs---SMSHDFSLVFHLTAL 1440 Phaeodactylum...
CBJ49271     1635 ppaglsleksggedrgsgrdrCVLRCLLAMYpsrkagggvgGA-S-GVSLLS--ALEPMAVt---PDVMDYRHSWHLMNV 1707 Ectocarpus si...
5A9Q_5        652 LRalN--YThlsAQCEGVLQASYAGQLESE---GLWEWAIFVLLH--------ID--NSGIREKAVRELLTRHCQLl--- 713 
XP_001750473 2577 LR--SlgAPqlnAHAEAQLLTDFAAQLEGA---GAWCHAVFVLLH--------LR--DDVPRTHAARTLVLRHLTAe--- 2638 Monosiga brev...
EGD80778     1754 LRa---lGVvasFPTERLLHVNFASQLEQM---GCLSAALAVMQH--------ID--DDATRSLLVRRFIMRHHEL---- 1813 Salpingoeca r...
XP_001565807  822 IRavQlpRDqayRDAELSVLLGMTAELECNd--eTWFWGLLPLHM--------IE--SPTNRLDAVRAFCKRNAMRasaq 889  Leishmania br...
1_pfamImport  183 LRa---iGYkleRQWESHIHQNFIRQLEGC---GLWGDALYVALN--------IS--DAAEREYTCRELLFRNADSl--- 243 
XP_002901259 1759 LRa---iGYkldREWESHIHQNFIRQLEGA---GLWEDAVYVALN--------IS--DVIERENTCRELLFRNADVl--- 1819 Phytophthora ...
3_pfamImport  185 LRa---fGYkldRQWESHIHQNFIRQLEGS---DLWEDAIYVALN--------IS--NTIERENTCRELLFRNADAl--- 245 
XP_001420436  318 LNaiGvlEGegmDALADEITVAFATQLLGMperGRCEWAVFVSQH--------LR--DDTRRTKMTGHILRERFEEw--- 384  Ostreococcus ...
XP_002180245 1441 IC--AtgATkndSFKTEYILNSFEAQLIQA---GRWDLAVIVCLSaigemsetLHhwKAHR----AKSLICRFSSD---- 1507 Phaeodactylum...
CBJ49271     1708 VEa-LgvAEvqdRAKAAAVTEGLRFQLVAV---GLWEWAVYVTL---------TAegDPDRRAATARELVLRHGYRvlga 1774 Ectocarpus si...
5A9Q_5        714 ---eTPESwaKETFLTQKLRVPAKWIHEAKAVR 743 
XP_001750473 2639 ----CREA--ERDFLKVELKVPETWLHEALAQD 2665 Monosiga brevicollis MX1
EGD80778     1814 -----HAA--TDAGLLAQLRVCPAWFAESALVa 1839 Salpingoeca rosetta
XP_001565807  890 kqlgEAQP--DYNRLMCLMHVNEGWLEPAVAPP 920  Leishmania braziliensis MHOM/BR/75/M2904
1_pfamImport  244 ---sSNAS--VRKSLCKRLNIPAEWISEALAVR 271 
XP_002901259 1820 ---aSDVA--KRELLCERLTLPPEWISEALAVR 1847 Phytophthora infestans T30-4
3_pfamImport  246 ---aSNVT--KREELCERLNIPTEWVSEALAVR 273 
XP_001420436  385 ---kCDDG--KIAFIKDVCAVPQESLDDAHALW 412  Ostreococcus lucimarinus CCE9901
XP_002180245 1508 ------ND--GKRLFLEETGIPRRWFEEALAYR 1532 Phaeodactylum tricornutum CCAP 1055/1
CBJ49271     1775 -pvnSPDA--ERGRFLEGLGIPGAWLHEAAAVR 1804 Ectocarpus siliculosus
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