Conserved Protein Domain Family
CXCR4_N

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pfam12109: CXCR4_N 
CXCR4 Chemokine receptor N terminal
CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. CXCL12) are essential for proper fetal development. CXCR4 is also the major coreceptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1), and SDF-1 inhibits HIV-1 infection. Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. The N terminal domain of most chemokine receptors is the ligand binding domain and so the N terminal domain of CXCR4 is the binding site for SDF-1.
Statistics
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PSSM-Id: 403362
View PSSM: pfam12109
Aligned: 7 rows
Threshold Bit Score: 64.4006
Threshold Setting Gi: 612018820
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007667673 283 IDIHDNSSDgdwsGSGSGDYDNyKEPCYRQENADFNR 319 platypus
XP_007494171  16 IEFHDNNTVe---GFGSGDYEG-KEPCYPNENEDFNR 48  gray short-tailed opossum
Q07FZ4        10 INIFDSNST----ENGSGDFEDfSEPCFMHDNSDFNR 42  tropical clawed frog
XP_002712170   6 IYTSDNYTE----ELGSGDYDSiKEPCFREENAHFNR 38  rabbit
XP_003215140   9 IFMTENSTD----EPGSGDDGDyQEVCLQQENADFNR 41  green anole
AAG09054      12 IEFADNGSE----EIGSADYGDyGEPCFQHENADFNR 44  chicken
XP_002198314  20 IELSENGTD----EIGSGDYGDyKEPCYQNENADFNR 52  zebra finch
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