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MrcB-like, N-terminal domain This model describes the N-terminal domain of a group of mostly uncharacterised proteins, including 5-methylcytosine-specific restriction enzyme B (also known as MrcB) from E. coli. MrcB recognises N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines) produced by a broad range of DNA methylases and appears to act against 5-methylcytosine preceded by a purine residue. The N-terminal domain of MrcB has been shown to be a DNA-binding domain, and the crystal structure has been solved. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",