Conserved Protein Domain Family
DUF3570
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pfam12094: DUF3570 
Protein of unknown function (DUF3570)
This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 396 to 444 amino acids in length. Proteins in this family contain the [S/T]GA[S/T] motif and thus, is flavinylated by ApbE. This suggests that they may be involved in extracytosolic redox activities.
Links
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Statistics
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PSSM-Id: 492366
Aligned: 16 rows
Threshold Bit Score: 382.124
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CCE22508        42 LQALTAAALILPG---------------------------LAPAAAQDNEFTFQYGRYEESRrdlgevtnldg------- 87 
jgi:Sama_1682   28 AAAVCLSSLAMIGfdaaatetpainsaeavkqashseddsLLTRLIDGWEIDAALLWYREDA------------------ 89 
Q085T6          10 ASALALASCSLLSqqas---------------------aaePIPATDDWKVDAAIMYYGEQD------------------ 50  Shewanella fr...
WP_012346088    33 clLAGVAAHPAMAqnvpqpas-----------atgttpakPAKPAAVPWQIDSAVLLYAEGDn----------------- 84  Leptothrix ch...
WP_238985351    21 LLALTSAALALPGlm-----------------------lpPAHAAFEGGEFNFQYGRYEEGGgtqsqf------------ 65  Nitrosococcus...
Q3JBS1          45 LLALTSAALALPGlm-----------------------plPSHAAFEGGEFDFQYGRYQEGGgtksqf------------ 89  Nitrosococcus...
WP_238527253    13 lqALTTAALFLPGl-------------------------tPTLAHAADDEVTIQYGHYEEAKrdiygplngnvnsdsfig 67  Methylomonas ...
jgi:Metme_0172  16 vvRLGCAALALPGlmq----------------------tvSAGRVEETYNADFQYGHYSEGKk----------------- 56 
Q604X6           7 LAAFSAAALALPGmva----------------------aqGLDLSPEAPAIDSGYSNYQESNg----------------- 47  Methylococcus...
Q21LI8          21 TKLLSAATCTLLAstaatan-------------tesssaeKSVVLGHKWSTQAAVLSYSEDG------------------ 69  Saccharophagu...

CCE22508        88 ---evvlnrsqfkPITVDSLQTTANVRLADRIKFAFKYVQDTWSGAT-------PVSTAPATRQGNvafgsgatmagasp 157
jgi:Sama_1682   90 -------------RVQAIEGVVSGVKALSDSESINAKIVLDSLSGAS-------ASGAVAQQWAQT-------------- 135
Q085T6          51 -------------RVQAAEAIGNVQKAFGDSSLLDLKIVVDSLTGAS-------ASGAVAQSDSQT-------------- 96  Shewanella fr...
WP_012346088    85 -------------RVRAVEPMIGMRRTDADDRTLAVRLTLDTLTGAS-------PNGATPQPAAQT-------------- 130 Leptothrix ch...
WP_238985351    66 --------rnkdnDIQVDSLETSGEIDLTDRLRFRANFIQDTWVGAT-------PITTAPAAAVRFnpnaqtgaspffdl 130 Nitrosococcus...
Q3JBS1          90 --------rdkdnDIQVDSLQASGEIDLSDRLTFRANFIQDTWVGAT-------PITTAPAAAIRFnpnaqtgasaftdl 154 Nitrosococcus...
WP_238527253    68 genvvkklpgqfaPITVDTIHAQAKTTLRDRWKFTANYTEDTWSGAT-------PVATAPAAFGGNqpfvlqsdgshsda 140 Methylomonas ...
jgi:Metme_0172  57 -------------RMEVDIFEGALAAPIGKNMTANVGILRDMVSGAS-------PV------------------------ 92 
Q604X6          48 -------------RMSVQAFQNDASLRLGEDVNFRVNSTLDFIGGGSnpmnlsqIGGASPTFYWGRn------------- 101 Methylococcus...
Q21LI8          70 -------------RISVNQGLLKLKGK-SDKSIVTLKMGYDVVSGPS-------ENGAAPSPTAQT-------------- 114 Saccharophagu...

CCE22508       158 flntggsaa----------grvffdsqlrpirtkldmnsfqvRSLGVDERNVHTMSVASP---------EVRKEGSFNLT 218
jgi:Sama_1682  136 ------------------------------------------FTRPSGKGEYQVAAGETPldd---tfqDTRLSLSGGWQ 170
Q085T6          97 ------------------------------------------FTRPSGDGQYTVAAGDTPldd---tfhDTRVQLSANWQ 131 Shewanella fr...
WP_012346088   131 ------------------------------------------FTSPSGEGSYSVPAGQAPlds---sfkDTRGAVNVSYD 165 Leptothrix ch...
WP_238985351   131 rggv---------------------vnfdidtgqgsatipgtFESVITAETVHVMAEASP---------ETRKQGDFNLS 180 Nitrosococcus...
Q3JBS1         155 kggi---------------------vdydtrtgegqatipntFDTVTTNETVHVMAEASP---------ETRKQGDFRMG 204 Nitrosococcus...
WP_238527253   141 eigqtitgatpqlnsldlafdaqfnpvllrrdglavpsfdtlVDKQPANQLTHTLTMASP---------ETRKQGDFKLS 211 Methylomonas ...
jgi:Metme_0172  93 ------------------------------------------YNRRVNGKIQQVLSGASPssqcgesicEQRDQITGGAT 130
Q604X6         102 -----------------------------------------nNYGRKYGELELSQATQGPqrgrqggihDQRLAIDGALS 140 Methylococcus...
Q21LI8         115 ------------------------------------------FTSPSGAEDYQVNAEELPwye---iirHPRKDISIDKS 149 Saccharophagu...

CCE22508       219 YEWDEA-TVSAGGGLSIENDYESRFANLGMTLDFNQKTTTVSGGLSYANSSTSALLNHDAQNY---INTsAYd---GALP 291
jgi:Sama_1682  171 KTLDSAtKVNAAVYGSKEFDYLSLGINGGIDWGFFKDNTTLSLSGALGYDLFDAVGGRPVPLStmaIRK-DF----ANDE 245
Q085T6         132 EVLNQDwTGNIGVYGSKEFDYLSMGINGGLERSFNKNNTTLSLSGAFTNDVVDPVGGRPVAMSemvFRG-NY----ANDA 206 Shewanella fr...
WP_012346088   166 RPWGENrRLSVGANVSAEYDFKSFGFNTSLSQDFNQKNTTLSVGLAGEYNLVNAVGGTPLGLGvh--------------- 230 Leptothrix ch...
WP_238985351   181 YEWDEA-ALDLGGGISLEDDYESRYFSLGGRWDFNQKLTTLTGGVGYINSTIDALR----------FPFrVTsvpvDPEG 249 Nitrosococcus...
Q3JBS1         205 YEWDEA-ALNLGGGISLEDDYDSRYVSLGGRWDFNQKLTTLTGGVSYTDSTIDVRR----------FRFrATsvpvDAEG 273 Nitrosococcus...
WP_238527253   212 YEWDEA-AVDLGGGLSVENDYESRFVNWGGRLDFNNKLTTLNFSQSYTNSTVSALLDHDSLPY---LGSiGYqlngKGDS 287 Methylomonas ...
jgi:Metme_0172 131 YFFEDS-SLNIGGGLSREHDYTSRFFNTAYSIDLNKKLTTLNFGASIAFDDIEP-----------------------SPS 186
Q604X6         141 VALDDL-TLGVAGGNSTEWDYISNFFNLDARWDINRKATTLAAGFGYASDTVWADGGNQGRIH----------------- 202 Methylococcus...
Q21LI8         150 TILNKAyTFNIGARYSTEATYDSRSINFGIVRNANKKNTQFSLSASYEDAAVTPYGGVVTPRSt-vLNRgQF----SSEE 224 Saccharophagu...

CCE22508       292 GLQPRYAKLEAVPfgq----------nvlRGKREDWTVNLGLTQIVTKSALAKFGASYTRSTGYLSNPY-KAVTAIFIDs 360
jgi:Sama_1682  246 AFWQAFDLSRQQG----------------VGDKRIAEMMLGVTQILTKSTLVQFNYGLGYSSGYLNDPY-KLVSVLDTD- 307
Q085T6         207 DYQAAFDQTRLAD----------------DDTKQTSDIMFGVTQIINRNWLMQANYGLSSVSGYMTDPY-KILSEVDVN- 268 Shewanella fr...
WP_012346088   231 -----sARARIEA----------------NQNRQIGDLLFGLTQVMNRRWLMQFNLGLGRSTGYHSDPY-KLLSVVNGSs 288 Leptothrix ch...
WP_238985351   250 EVNPDFPDWSVRV----------------NDRRTDTSVNLGLTQVLDKNSVFKAGFGYTHSSGFLSNVYkESVFFVPLEt 313 Nitrosococcus...
Q3JBS1         274 GINPDFPDWSVRL----------------HDGRTDIGASLGLTQVLDKNSTFRASFGYNHNSGFLSNPYkEVTFLTPLDt 337 Nitrosococcus...
WP_238527253   288 GYIERF--VDPLSggn----------ailHGKREDIATNISLTQVLSKSALAEAGVGYTHSSGFMENPY-KATYVFFVDp 354 Methylomonas ...
jgi:Metme_0172 187 GFNSHVNGFKRYKtgq--------------------nylVGVSQVVDKDTLFQSNMTFGYSNGYLTDPYkNVATEGNPN- 245
Q604X6         203 ---------QQYTdgt-----------viGGDKNTYQGLLGLTQVLDKNSLLQVNLTVANSSGFLSDPY-KSAWVNDVPa 261 Methylococcus...
Q21LI8         225 EFMAAWRAQRANGasttglvggitsedntTENKTVWGLVAGATQVVNKDTLVQFNYSYGESSGYQNDAQ-KMVSIIDTD- 302 Saccharophagu...

CCE22508       361 nvsgq-----------------------------------------cdfglDCpadvryvGQSKAFl--EQRPELRNQWS 397
jgi:Sama_1682  308 ---------------------------------------------------GN-------ASHYLY---ESRPDSRLKQS 326
Q085T6         269 ---------------------------------------------------GQ-------TQAYRY---ENRPDSRLKHS 287 Shewanella fr...
WP_012346088   289 ---------------------------------------------------GLl-----sGDQYLS---ENRPDTRSRTS 309 Leptothrix ch...
WP_238985351   314 -----------------------------------------------------------pGMSWLFtryDKRPEEREQFN 334 Nitrosococcus...
Q3JBS1         338 -----------------------------------------------------------pGKAWLFtryDKRPEERNQFT 358 Nitrosococcus...
WP_238527253   355 nsfda-------------------------------------------------drglytSQVTAFt--EQRPNKRNQVN 383 Methylomonas ...
jgi:Metme_0172 246 -----------------------------------------------------------------FyvqEIRPGHKFTWA 260
Q604X6         262 vrspsrrsasaraapdmsthsgasggspepspspvpapdqpaevpatpvntFCrqnvpfsFQINLCa--DTRPGSRIQSA 339 Methylococcus...
Q21LI8         303 ---------------------------------------------------GL-------VTSNIY---EARPDHRVKQS 321 Saccharophagu...

CCE22508       398 FDTGWVQYINp-lDAALHFDYRFYFDDWGINAHTFDADWVQPLGLGW--SVTPRVRYYSQSEADFYTPFLIAGpsddpgn 474
jgi:Sama_1682  327 AFVLGKTAFK---RGVAEYSYRYTHDDWGLDSHTVEGRYRHYFSTKTgpYLQFHLRGYRQQGVDFFTPYLLQG------- 396
Q085T6         288 VFLLTKGALD---SGVVDFSYRYSTDDWEIQSHTLETHYRYYFSPSM--YGQLHLRYYQQQAAEFYQPFLMSG------- 355 Shewanella fr...
WP_012346088   310 LFWLNKLHLG---TEVLELSLRHYRDDWGVRANTVDGKWRHQYSGGI--YVEPHLRLYKQGAAEFYRGWLVDGvdhd--- 381 Leptothrix ch...
WP_238985351   335 WNIGYSRYLAg-lDAALHFNYNFFHDDWGINAHTFDVSWGQPIGGGW--TITPTVRYYSQSAADFYSPFFIVDqgpfsvg 411 Nitrosococcus...
Q3JBS1         359 WSAGYTRYLAr-lDAGLHFNYNFFHDDWGINAHTFDASWGQPVGGGW--IITPRVRYYSQGAADFYSPFFIASqeplsla 435 Nitrosococcus...
WP_238527253   384 LNLRYVQHVEp-lDAAMNLKYNYFFDDWGINAHTFEGKWVQPLPWGL--TVTPTIRYYSQSAADFYHPFLVLKnagsgnv 460 Methylomonas ...
jgi:Metme_0172 261 WLNQYVRHFGqlnDAALHVDYRYSLDDWGSHAHTFELAWHQPIADNW--QIIPRFRYYSQDRVDFYQPIFDDTlkfdfna 338
Q604X6         340 VLLRYVRNIPeldAAALHLDYRFYSDDWNVDSHTFEAGWLQPLPYET--LLTFRLRYYTQRSAYFYQTVYDHPta----- 412 Methylococcus...
Q21LI8         322 VYGKIKYSTSk--STVLDVNYRYYWDDWGISSHTLAAGYQIEISKRF--KIEPQFRIYKQSDADFFRHSVFEEns----- 392 Saccharophagu...

CCE22508       475 -ardssdnSKLPt-QTFSSDHRLSGFGALSGGVTVSKQFT-----KGVRLDASVEYYMHR------------GDWKIGGG 535
jgi:Sama_1682  397 --------EVVS--PHISADYRIGDMDTWTIGLKTGWRLK-----DGDEIALRLEYYRQLpsgevs-sleglQGLDVYPE 460
Q085T6         356 --------DAIP--EYASADYRIGDMTAYTIGLKFGQRLS-----GGHELSYRIEYYQQNpenngteipgqlQNYDLFPA 420 Shewanella fr...
WP_012346088   382 ----stthQARL--AYASADQRLAAFSAQTVGLKVGLPVG-----TGGEFSVRLESYRQKlkqpag-apgylATVPVSPD 449 Leptothrix ch...
WP_238985351   412 --eilanqSQLPtpDHFSSDHRLSAFGALSGGVTLSKQFA-----KGVTLEAGFEYYTHA------------GSLKLGGG 472 Nitrosococcus...
Q3JBS1         436 --eilpnqSQLPtpEHFSSDHRLSAFGALSGGVTVSKQFA-----KGVTLEAGFEYYTHA------------GSLKLGGG 496 Nitrosococcus...
WP_238527253   461 nne-adyrnlvrqyPNFSSDHRLSAYGALSGGVVVNKQFA-----QGLNLEMGFEYYTHQ------------GGLRLGGG 522 Methylomonas ...
jgi:Metme_0172 339 pgykgnfnttlenhNVYSSDYRLAGFGALSGGIKLSKEITsingvNSLKFQTGFEYYRHE------------AGLQLGGN 406
Q604X6         413 -------------dGLYSSDYRLASFGAVGGGLQVNKTFF-----GMLQIGGGVDLYQRT------------QGMGFMGG 462 Methylococcus...
Q21LI8         393 ------npDDLP--MYLSADYRLAATTNYTLGVNFDYHLK-----NKHVVSVRLATYTINpeedsqykrgylNTVNVLPS 459 Saccharophagu...

CCE22508       536 GEPAYADFNFLV 547
jgi:Sama_1682  461 LNAAMLQLNYSW 472
Q085T6         421 VKAIVAQVSYSF 432 Shewanella frigidimarina NCIMB 400
WP_012346088   450 LKSTLLMASYSF 461 Leptothrix cholodnii
WP_238985351   473 GTGDFADFNYFL 484 Nitrosococcus halophilus
Q3JBS1         497 GTGDFADFNYFL 508 Nitrosococcus oceani ATCC 19707
WP_238527253   523 GEGGYANFSAYS 534 Methylomonas methanica
jgi:Metme_0172 407 SQGSFADFNYYV 418
Q604X6         463 TGSHVDNFSFAL 474 Methylococcus capsulatus
Q21LI8         460 INSTVVALSYEF 471 Saccharophagus degradans 2-40
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