6T9I


Conserved Protein Domain Family
Spt20_SEP

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pfam12090: Spt20_SEP (This model is not part of the current CDD release)
Spt20, SEP domain
This is the SEP domain found in Spt20 proteins from both human and yeast. The Spt20 protein is part of the SAGA complex which is a large complex mediating histone deacetylation. Yeast Spt20 has been shown to play a role in structural integrity of the SAGA complex as as no intact SAGA could be purified in spt20 deletion strains. Spt20 is indispensable under endoplasmic reticulum (ER) stress conditions, being involved in the regulation of stress-responsive genes transcription. This domain interacts with LisH motif helices of Taf5.
Statistics
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PSSM-Id: 520066
Aligned: 25 rows
Threshold Bit Score: 57.8043
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6T9I_B        131 EQYLHSFEFHIY--ENNYKIcapansrlq------------------------------------qqqkqpelTSDGLI- 171  Saccharomyces...
O14174         62 SKEEPSLILHIH--KFHFRF-----------------------------------------------------EQQDGA- 85   Schizosacchar...
Q54VY3        264 SSYKTSLYICLY--PIGYAId---------------------------------------------------nIYKDKI- 289  Dictyostelium...
Q2PDX8        342 REKLNTIVVNLYpgNKGYSLalhydehmvlnpqtnewsptdkdetssdaaglgtgtgshrsrpkplaqdesqsKTEAGHa 421  fruit fly
EDO44494        9 QDNLSTLVVNLYpnNEGYSLmlkgkng----------------------------------------------------- 35  
F4IDB2         61 PDHEVSFILSLY--PNGYSIg----------------------------------------------------KTSEAMq 86   thale cress
XP_001313599  103 STFSVSLHLILR--PKTFSFf----------------------------------------------------TTNPGId 128 
XP_001311590   80 EDFNVSFNFEFH--PKVFTLal-------------------------------------------------gdGSNPRT- 107 
XP_001303029   89 YQERASIIIKFW--PEYFSIe---------------------------------------------------dKTDKRIe 115 
XP_001307109   86 YSDKTSVEFKFW--NDYFTIss-------------------------------------------------knSHENEIp 114 
6T9I_B        172 -----------LTKNNEtLKE-FLEYVARGRIPDAIMEVLRDCN------------------------------------ 203  Saccharomyces...
O14174         86 -----------FTYNGP-VKS-ILQYIRMELIPPDCLEVFRNSD------------------------------------ 116  Schizosacchar...
Q54VY3        290 -----------FTYNDK-ISKdFLNSISQGKLTPYIINILDQLSeqndqkqqqqqqqqqqqqqqqqqqqqqqqqqqqtnn 357  Dictyostelium...
Q2PDX8        422 khdfglvevlrWPYEND-L---LLQCIDREMLPEFLMDLLVAETvslsdgeg---------------------------- 469  fruit fly
EDO44494       36 ----sesetikLPYEET-Q---FLDYLDAQELPPILVDLLERSQa----------------------------------- 72  
F4IDB2         87 qisfrdvpkvlHPYDRA-AEG-LLSAIEAGRLPGDILEDIP--------------------------------------- 125  thale cress
XP_001313599  129 v---------tESFEDE-GAH-ILDFISRGYLPPRMFEELRKLN------------------------------------ 161 
XP_001311590  108 -----------FQYNTK-SRE-LIRCSETGCISEELLQLFNTFGk----------------------------------- 139 
XP_001303029  116 -----------FEYKQH-ICP-ILQDLEKCKIGKMFYTLLSNFK------------------------------------ 146 
XP_001307109  115 -----------FCYNNN-LYP-ILEDIENGVISKMLFKILRYFK------------------------------------ 145 
6T9I_B        204 -------IQFYEGNLILQVYDHTNTVDVTPkenkpnlnsssspsnnNST-----QDNSkIQQPSEPNSGvantgantaNK 271  Saccharomyces...
O14174        117 -------VKFYDGCLTVRIIDHRQSPSADQt--------------vQPQpgstnQQQQnNTNPINNQPE---------DT 166  Schizosacchar...
Q54VY3        358 iyqnsneITYYNGCIVVNIKDYRGF-----------------------------AENEqIAKTFNSKNM---------KP 399  Dictyostelium...
Q2PDX8        470 trvyakpSVFYAGCVIAQIRDFRQTFATSTn--------------iCDMkh----------------------------- 506  fruit fly
EDO44494       73 -------NIFYSGCVIVEVRDYRQNLSSSS----------------YDTky----------------------------- 100 
F4IDB2        126 -------CKFVDGVVICEVHDYRKH------------------------------------------------------- 143  thale cress
XP_001313599  162 -------LVWYDGGLICEIDDQRRNNGN---------------------------------------------------- 182 
XP_001311590  140 -------IQWTDGSIIVRITDYRFEPQ----------------------------------------------------- 159 
XP_001303029  147 -------LEFINGKIITSIIDFRNTPE----------------------------------------------------- 166 
XP_001307109  146 -------LEFLDGKVLVAIIDYRSNIE----------------------------------------------------- 165 
6T9I_B        272 KASFKRPRVY------RTLLKPNDLTTYYDMMSYADNA------------------------------------------ 303  Saccharomyces...
O14174        167 KPNTNSPPVY------HTVLRPTPETLWQDLCLLSESFa----------------------------------------- 199  Schizosacchar...
Q54VY3        400 YPITVPIGTFkefiekRIILKPTMESLLFDIKKNCSTLnndnknnninninninnnnnnnnnnnnnnnnnininnnnnin 479  Dictyostelium...
Q2PDX8        507 -----------------iLLRPTNATLFAEVQQMGS-------------------------------------------- 525  fruit fly
EDO44494      101 -----------------vLLRPTYQSLVCDVNNLTSDp------------------------------------------ 121 
F4IDB2        144 TSSQVSPVIN------KLRLKMSLENVVKDIPSMSDn------------------------------------------- 174  thale cress
XP_001313599  183 ------------------VMRTLLSVAPSDIAALGP-------------------------------------------- 200 
XP_001311590  160 ------------------------RTYTYPLTIGQDVIlsf--------------------------------------- 176 
XP_001303029  167 ------------------------QYFFAELSISSDFIr----------------------------------------- 181 
XP_001307109  166 ------------------------QRHYAELSITPEYFk----------------------------------------- 180 
6T9I_B        304 ---------RFSDSIYQQFESEILTLTKRNLSLSVPLNPYEHRDMLE 341  Saccharomyces cerevisiae S288C
O14174        200 --------nSLSDEAVLTLESNILLASEAPLFLTPAKSKAEMIQFMN 238  Schizosaccharomyces pombe 972h-
Q54VY3        480 nylnikeseIVNEEYLLNFEKCLLHAITPQLELSVNPNCF--FDQLE 524  Dictyostelium discoideum
Q2PDX8        526 ---------QLPAEDKLALESQLVLATAEPLCLEPDPSIGRQAINSQ 563  fruit fly
EDO44494      122 ---------SWSVDDKLALEAQLLLATEGPLCLNPNPEVGLVANQLQ 159 
F4IDB2        175 ---------SWTYGDLMEVESRILKALQPELCLDPLPRLDRLSKNPL 212  thale cress
XP_001313599  201 -----------------ECESEFLLVKYPLISFDSDIQISKVSRIAS 230 
XP_001311590  177 ------gakALSEEEHLEAQKNILLVANPDLTLDPSPDVARINCVLD 217 
XP_001303029  182 --------sDFKNTDYLTSEKIFIDLTNKNICTDPSPDVSRYNSILD 220 
XP_001307109  181 --------eLTKEYPPIIQDKIFTDLTSKEICNDPSPNVARYSSIVD 219 
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