Conserved Protein Domain Family
Spt20

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pfam12090: Spt20 
Spt20 family
This presumed domain is found in the Spt20 proteins from both human and yeast. The Spt20 protein is part of the SAGA complex which is a large complex mediating histone deacetylation. Yeast Spt20 has been shown to play a role in structural integrity of the SAGA complex as as no intact SAGA could be purified in spt20 deletion strains.
Statistics
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PSSM-Id: 371892
View PSSM: pfam12090
Aligned: 24 rows
Threshold Bit Score: 49.6112
Threshold Setting Gi: 74856011
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q54VY3        201 NNNNIle----kESNGVQEIEDSPNHLSLkrklmilee------mglisddnNKNNNN---------------------- 248  Dictyostelium...
EAX98660       74 LPNKLf-----eDFNVSFNFEFHPKVFTL-----------------------ALGDGS---------------------- 103  Trichomonas v...
EAX94179       75 KFNKLtpdfeiySDKTSVEFKFWNDYFTIs----------------------SKNSHE---------------------- 110  Trichomonas v...
XP_001303029   78 SFNILtpnfdtyQERASIIIKFWPEYFSI------------------------EDKTD---------------------- 111  Trichomonas v...
Q2PDX8        335 TLERLvd----rEKLNTIVVNLYPGNKGYslalhydehmvlnpqtnewsptdKDETSSdaaglgtgtgshrsrpkplaqd 410  fruit fly
EDO44494        2 LLEKVvl----qDNLSTLVVNLYPNNEGYslm-----------------lkgKNGSES---------------------- 38   starlet sea a...
XP_002373197  128 TTSHIlkk--ygKCPPSLILHLHPTHFRF---------------------------EQ---------------------- 156  Aspergillus f...
Q2GUX4         67 SARTLnr----qRHPPSLIIHLHQTYFRF---------------------------DK---------------------- 93   Chaetomium gl...
O14174         53 KLHDIehk--fsKEEPSLILHIHKFHFRF---------------------------EQ---------------------- 81   Schizosacchar...
XP_001313599   92 TNFDVlpenaysTFSVSLHLILRPKTFSF-----------------------FTTNPG---------------------- 126  Trichomonas v...
Q54VY3        249 ------------------NSIDIPNSNRLnQIPSSYKTSLYIclypiGYAIDNIY-------------KD-K--IFTYND 294  Dictyostelium...
EAX98660      104 ------------------NPRTFQYNTKS-RELIRCSETGCI-----SEELLQLF-------------NTfGk-IQWTDG 145  Trichomonas v...
EAX94179      111 ------------------NEIPFCYNNNL-YPILEDIENGVI-----SKMLFKIL-------------RYfK--LEFLDG 151  Trichomonas v...
XP_001303029  112 ------------------KRIEFEYKQHI-CPILQDLEKCKI-----GKMFYTLL-------------SNfK--LEFING 152  Trichomonas v...
Q2PDX8        411 esqskteaghakhdfglvEVLRWPYENDL---LLQCIDREML-----PEFLMDLLvaetvslsdgegtRVyAkpSVFYAG 482  fruit fly
EDO44494       39 ------------------ETIKLPYEETQ---FLDYLDAQEL-----PPILVDLL-------------ERsQa-NIFYSG 78   starlet sea a...
XP_002373197  157 ------------------QDGSFPYNSEM-KVIIEHIRAGTV-----PHDMIEEL-------------LRaN--VRFYEG 197  Aspergillus f...
Q2GUX4         94 ------------------QEGMFPYHSPM-RIFLEHLRSRTV-----PHEMLDQL-------------TQaG--VPFYDG 134  Chaetomium gl...
O14174         82 ------------------QDGAFTYNGPV-KSILQYIRMELI-----PPDCLEVF-------------RNsD--VKFYDG 122  Schizosacchar...
XP_001313599  127 ------------------IDVTESFEDEG-AHILDFISRGYL-----PPRMFEEL-------------RKlN--LVWYDG 167  Trichomonas v...
Q54VY3        295 KI---SKDFLNSISQgkltpyiinildqlseqndqkqqqqqqqqqqqqqqqqqqqqqqqqqqqtnniyqnsneityyngc 371  Dictyostelium...
EAX98660      146 SIivrITDYRFEPQR----------------------------------------------------------------- 160  Trichomonas v...
EAX94179      152 KVlvaIIDYRSNIEQr---------------------------------------------------------------- 167  Trichomonas v...
XP_001303029  153 KIitsIIDFRNTPEQy---------------------------------------------------------------- 168  Trichomonas v...
Q2PDX8        483 CViaqIRDFRQTFATstn-------------------------------------------------------------- 500  fruit fly
EDO44494       79 CViveVRDYRQNLSSss--------------------------------------------------------------- 95   starlet sea a...
XP_002373197  198 CLivrVVDHKSVSAQarkstapstndsntpfsihnynehvtpsayvpypkqnqltsekp--------------------t 257  Aspergillus f...
Q2GUX4        135 CLivqVHDHKSVAQArdvarptsassktapfsihnynqyitpsahvpypkenlpa------------------------- 189  Chaetomium gl...
O14174        123 CLtvrIIDHRQSPSAdqtvqpqpgstnqqqqnnt---------------------------------------------- 156  Schizosacchar...
XP_001313599  168 GLiceIDDQRRNNGN----------------------------------------------------------------- 182  Trichomonas v...
Q54VY3        372 ivvnikdyrgfaeneqiaktfnsknmkpypitvpigtfkefiEKriilkPTMESLLFDIKKNCSTlnndnknnninninn 451  Dictyostelium...
EAX98660      161 ------------------------------------------TY-----TYPLTIGQDVILSFGA--------------- 178  Trichomonas v...
EAX94179      168 ------------------------------------------------hYAELSITPEYF-------------------- 179  Trichomonas v...
XP_001303029  169 ------------------------------------------------fFAELSISSDFIR------------------- 181  Trichomonas v...
Q2PDX8        501 ---------------------------------------icdMKhillrPTNATLFAEVQQMGSQ--------------- 526  fruit fly
EDO44494       96 ----------------------------------------ydTKyvllrPTYQSLVCDVNNLTSD--------------- 120  starlet sea a...
XP_002373197  258 skeaetqsdtnangehasdsqeqpeksessssqhkqtppkprVFttvlhPTPHSLRAELALLATTpdpkaakqgatssas 337  Aspergillus f...
Q2GUX4        190 ---agvpalaaektaeekdkenmpapsapadgqkgkgtakpkIFttvlhPTQQSLHTDLSIKAATprgasdaradgtvpp 266  Chaetomium gl...
O14174        157 ------------------------npinnqpedtkpntnsppVYhtvlrPTPETLWQDLCLLSESf-------------- 198  Schizosacchar...
XP_001313599  183 ------------------------------------------VMrtllsVAP----SDIAALGP---------------- 200  Trichomonas v...
Q54VY3        452 innnnnnnnnnnnnnnnnininnnnninnylnikesEIVNEEYLLNFEKCLLH-AITPQLELSVNPNCFfdq-letKQKQ 529  Dictyostelium...
EAX98660      179 ------------------------------------KALSEEEHLEAQKNILL-VANPDLTLDPSPDVA-------RINC 214  Trichomonas v...
EAX94179      180 ------------------------------------KELTKEYPPIIQDKIFTdLTSKEICNDPSPNVA-------RYSS 216  Trichomonas v...
XP_001303029  182 ------------------------------------SDFKNTDYLTSEKIFID-LTNKNICTDPSPDVS-------RYNS 217  Trichomonas v...
Q2PDX8        527 --------------------------------------LPAEDKLALESQLVL-ATAEPLCLEPDPSIGrqainsqHQRQ 567  fruit fly
EDO44494      121 ------------------------------------PSWSVDDKLALEAQLLL-ATEGPLCLNPNPEVG-------LVAN 156  starlet sea a...
XP_002373197  338 rtqaassa------appspggstnppergpvakrqkMLVEPQDLAECEAKLTR-ALAPPLFLEPVQSLD-------AAQD 403  Aspergillus f...
Q2GUX4        267 ptphaa---------vpptptaasmqpptkkqklerMQLDASNIYEAEAQILL-ATTAPLDLEPTKNAE-------ETIA 329  Chaetomium gl...
O14174        199 -----------------------------------aNSLSDEAVLTLESNILL-ASEAPLFLTPAKSKA-------EMIQ 235  Schizosacchar...
XP_001313599  201 ---------------------------------------------ECESEFLL-VKYPLISFDSDIQIS-------KVSR 227  Trichomonas v...
Q54VY3        530 LYNQS 534  Dictyostelium discoideum
EAX98660      215 VLDDR 219  Trichomonas vaginalis G3
EAX94179      217 IVDWR 221  Trichomonas vaginalis G3
XP_001303029  218 ILDWR 222  Trichomonas vaginalis G3
Q2PDX8        568 LYNSH 572  fruit fly
EDO44494      157 QLQFN 161  starlet sea anemone
XP_002373197  404 LLKFM 408  Aspergillus flavus NRRL3357
Q2GUX4        330 LLQKQ 334  Chaetomium globosum CBS 148.51
O14174        236 FMNQL 240  Schizosaccharomyces pombe 972h-
XP_001313599  228 IASSD 232  Trichomonas vaginalis G3
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