Conserved Protein Domain Family
KN_motif

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pfam12075: KN_motif 
KN motif
This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.
Statistics
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PSSM-Id: 403337
View PSSM: pfam12075
Aligned: 13 rows
Threshold Bit Score: 73.5323
Threshold Setting Gi: 612012570
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014326532   25 PYSVET----PYGFHLDLDFLKYVD--DIEKGNTIK-RVH---IQRRVK 63   southern platyfish
XP_007489532   29 PYSVET----PYGFQLDLDFLKYVE--DIESGQGLRsRAP---LPTRRP 68   gray short-tailed opossum
NP_725426      38 TRSVRScnccPYGYHIDLDFVRYCEalALEKPSEEEqRRR---DRRRSR 83   fruit fly
EDL86619       32 PYSVET----PYGFHLDLDFLKYVE--EIERGPASR-RAPgppHARRPR 73   Norway rat
XP_009861561   71 gYGLRT----PYGTHLNLDFVKYCE--ELMSGQSFK-RTS---SFRRPR 109  vase tunicate
NP_001244078   31 AYSVQT----PYGFELDLDFLKYVE--EIESGHSIR-RAN---VHPRRg 69   zebrafish
XP_030583193   31 SYSVQT----PYGFQLDLDFLKYVE--EIESGHNLR-RAP---ISSRRs 69   flier cichlid
XP_030113012   73 SYSVET----PYGFLLDLDFLKYVD--DIESGQTLK-KVP---LPRRLk 111  zebra finch
XP_005989925   30 lYSVET----PYGFQLDLDFLKYVD--DIQSGQTLR-KVN---VQRKSK 68   coelacanth
XP_004595809   31 PYSVET----PYGYRLDLDFLKYVD--DIEKGHTLR-RVA---VQRRPR 69   American pika
XP_005171947   26 PFSVNT----PYGYQLDLDFVKYVD--DIERSDTIR-RLR---FNKRPg 64   zebrafish
XP_016357063   71 PYCLET----PYGYQLDLDFLKYVD--DIERGNTIK-KLN---IQRKPK 109  Sinocyclocheilus anshuiensis
XP_023601866   32 SYTVET----PYGFHLDLDFLKYVE--ELERGPVAR-RAPsaqLARRPR 73   little brown bat
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