CDD Conserved Protein Domain Family: KN

pfam12075: KN_motif (This model is not part of the current CDD release)

KN motif

This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.

NP_725426 38 TRSVRScnccPYGYHIDLDFVRYCEalALEKPSEEEqRRR---DRRRSR 83 XP_007489532 29 PYSVET----PYGFQLDLDFLKYVE--DIESGQGLRsRAP---LPTRRP 68 1_pfamImport 1 SYTVET----PYGFHLDLDFLKYVE--ELERGPVAR-RAPsaqLARRPR 42 XP_014326532 25 PYSVET----PYGFHLDLDFLKYVD--DIEKGNTIK-RVH---IQRRVK 63 XP_005989927 30 LYSVET----PYGFQLDLDFLKYVD--DIQSGQTLR-KVN---VQRKSK 68 coelacanth XP_057345891 31 PYSVET----PYGYRLDLDFLKYVD--DIEKGHTLR-RVA---VQRRPR 69 Chinese pangolin XP_009861561 71 GYGLRT----PYGTHLNLDFVKYCE--ELMSGQSFK-RTS---SFRRPR 109 vase tunicate

Conserved Protein Domain FamilyKN_motif

Conserved Protein Domain Family
KN_motif