Conserved Protein Domain Family
KN_motif
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pfam12075: KN_motif (This model is not part of the current CDD release)
KN motif
This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.
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Statistics
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PSSM-Id: 492351
Aligned: 7 rows
Threshold Bit Score: 66.3257
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_725426      38 TRSVRScnccPYGYHIDLDFVRYCEalALEKPSEEEqRRR---DRRRSR 83  
XP_007489531   29 PYSVET----PYGFQLDLDFLKYVE--DIESGQGLRsRAP---LPTRRP 68  
XP_023601864   24 SYTVET----PYGFHLDLDFLKYVE--ELERGPVAR-RAPsaqLARRPR 65  
1_pfamImport    1 GYGLRT----PYGTHLNLDFVKYCE--DLMSGQSFK-RTS---SFRRPR 39  
2_pfamImport    1 PYSVET----PYGYRLDLDFLKYVD--DIEKGHTLR-RVA---VQRRPR 39  
XP_005989925   30 LYSVET----PYGFQLDLDFLKYVD--DIQSGQTLR-KVN---VQRKSK 68  
XP_014326532   25 PYSVET----PYGFHLDLDFLKYVD--DIEKGNTIK-RVH---IQRRVK 63
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