8I9X


Conserved Protein Domain Family
Gcn1_N

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pfam12074: Gcn1_N (This model is not part of the current CDD release)
Generalcontrol nonderepressible 1 (Gcn1) N-terminal
This entry represents a set of three HEAT repeats found towards the N-terminal region of Gcn1 protein, which acts as a translation activator that mediates translational control by regulating Gcn2 kinase activity. It is a ribosome collision sensor that activates a translation quality control pathway when a ribosome has stalled during translation.
Statistics
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PSSM-Id: 520060
Aligned: 78 rows
Threshold Bit Score: 230.599
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8I9X_LR        365 DHRVLHSEMLSGLPLSASIATKIATGLPAVTSKEANEAALSAETLALNASALFLLRTP-EVPKALLDAYVKGLGDKKVSS 443  Thermochaeto...
15_pfamImport    2 DHRAALYIILSSVPPSEVTSVEIQTTALAALSKESHEPVVRALLQAVSIHVPYLLAQNvAIGASQTGSLVKAMQETKATT 81  
3_pfamImport     1 DHRQALYSMIPNIPSRDDLCVDVAGTTFALWEKETSEVAISTLAEASSSHLADLLRRGtALGDKTESIIVKEAASVKPAQ 80  
2_pfamImport     2 DHRVALYSMLHALSPSNAISSNIVQIVPTLVLKESQDGAMAILASTLPSHLVFLLRSDiAVPSDVSSIIAKEMNNTKPVI 81  
XP_007328107   393 ENRIALYSMLAFLQPGTEVSSTLVEAAIPLLAKEQNEVATAKLATSLGPHITFLLKFDtDKLKDVTPLIVKDMNSVKPAV 472 
XP_001829939   416 EHRVALYSMLGYVRPSNDVSPVLIQSSTPLLAKETNEAAIAVLANALPPHITFLLRSStALPSEAVQLIAKEMGSLKPPV 495 
XP_007398289   419 DHRVALYTMLGYLPPSQEVSPTAVEAGPSLLAKETNDGAITVLALSLARHIVFSLCENlALPVATQTAITKEMNAAKPPV 498 
9_pfamImport     2 DHRVALYSMLGCLTPSPAISLTVVQSALPLLAKETHDAPIPLLRSALSSHLGFCLRNStVLSTDSVVVLAKEMNNTKPMI 81  
XP_024338474   419 DHRMALYSMLGFVRPATSASTAIMQTSLPLLAKETHDGAISVLTSALVPHLVFCLRENiVLPGDAVSVITKELMGAKPVI 498 
14_pfamImport    2 DHRVALYTMLGTVKPSP-ASVAILEAGLPLLAKETHDSAVSALAASVTPHLSHCLHEDlPIPSDIMAILAKEMTSAKPVV 80  
8I9X_LR        444 RRIWILRTGDLLQAFAQea----elPAGF--VA--FAEAVVPSLLTIFNEVVANPTaAVQSGLVtGALVVAGLS-GLLQR 514  Thermochaeto...
15_pfamImport   82 RRAAHAAVGDVFWALSQsl-----tERTDaaVA--FATGVLPGIESALKLLGSNPVnAPSGPL--EGYVAVAVLkTQLRL 152 
3_pfamImport    81 RRAMLTLIGEAFWALH-----------TGgdSQseSASALLKKLESGLLKLLKDASiSTVVQGVvDHWIALLLVlRQTGS 149 
2_pfamImport    82 RRAFCLLAGATLWEMGE--------LSTDasIV--FAKALSASFEINLKNVATNPLnSTVGPL--EGYIAIFALlGPFKR 149 
XP_007328107   473 RRAFVALAGDIFYEESSv------sLEDEkaVV--FMKALLSAFETSLKNVSGNVLnNPAGPL--EGYIAVAVLlGPLHH 542 
XP_001829939   496 RRAFATLVGSVFYEDEGdgegkgvvGESEagKA--FAKAVAPSLENALKSVAANPInAPGGPL--EGYVALATLlGPFAR 571 
XP_007398289   499 RRAFSSLVGNVLWELDN--------LSTQaaLD--FAKAVLPSLETSLKTVAASPAaPPAGPL--EGYIAVALLlGPYHR 566 
9_pfamImport    82 RRAFCSLVGDAFWDLED--------LESEatVT--LAKALLPAFETNLKTVSASPLtAPAGPL--EGYIAAAVIlGKLAR 149 
XP_024338474   499 RRAFCSLVGDAFWQLEV--------LHTEvsLS--LAKAVLPALDTNLKTVAAAPLtSAAGPL--EGYTAVAVLlGPFSR 566 
14_pfamImport   81 RRATCNLVADAFATLRLi------eQPSSaaET--LGRALLPAFETNLKTVASSPLtAPAGPL--EGYTAVATLlGRISA 150 
8I9X_LR        515 LENANIQALLKKAA-VQKNSLILDPKPSFVLSQRLYSKYP-EDDLKWFCRALSAIVEGL--LSS-SDAIKLAWTQAFIFL 589  Thermochaeto...
15_pfamImport  153 WDVKKIEDMLKANV-TMKGLLVGGAKPSFLLWDKVYRKATtAEEELWLLRAIESVIIADatTVEkNDALQSSLFQVIAHL 231 
3_pfamImport   150 S---------THSStLLQGILFPSGKPSFLYSEKNYQKVDdPKEAIWLLRVLDTLTTHSddLVR-QEKASLYFGQTLLWL 219 
2_pfamImport   150 SG--SFDDIVSRNT-SAQSLTGTPTKPSFLLWDKVYQKVNdPEDENWLLRAANVALFSLkaDLSkNEQSRTQIGSVYLHL 226 
XP_007328107   543 LG--RFDDVISKNA-VIGAIATSTVKPSFLLWEKVYQKATeEVDEMWLLRALKVSLRYFkkELVkNEVLRINFGSALLHL 619 
XP_001829939   572 SG--IFDELISKNA-VVQAIVASSAKQPFLLWDKVYQKVTdPADEKWLLRAANAAFKHFhsQIAkSEGLKVQFGLVFVHL 648 
XP_007398289   567 SG--KFEDFISRNT-SSQSLLATGAKPSFLLWDKVYQKLVePEDQAWLLRAGEAVLSYYknDILkSEQTSAMVGNLFLHL 643 
9_pfamImport   150 CS--AFDTFVSQNT-LVQSLMTVGTKPSFLLWDKVWQKVSdVEDERWMLRASIAALAFFkpQLArNEQARGALGMSLLHL 226 
XP_024338474   567 SG--NFDDVIAHNA-TVQSLMTAGSKPSFLLWDKVYQKLNgEDDEKWLLRAAQASLAFFqrELLrNKQACAMIGMVFLHL 643 
14_pfamImport  151 SP--GFGDFIARNS-TLQSILTAGAKPSFLLWDKVYQKLGsLEEENWLLYAAEATLLYFnkELSqNEQACAMIGMVFLHL 227 
8I9X_LR        590 ICSAtTPSAVRRQAIDALSDLSARSlkpgCQFVATEIIKGLWHWIATS----EAAEKESAAVLAKSGTSN---------- 655  Thermochaeto...
15_pfamImport  232 ILHS-SYFETRTAATRTLASLQRTN----SNLVHSIVGKGLLDWIT-------QDPSAGKTKPTSEDAPTpvdl------ 293 
3_pfamImport   220 AVDH-PSPTIRRETLSTLKRLSAAI----PVPISNAINLASNNLLFGDskqaKEEESSPHRSLRLSAA------------ 282 
2_pfamImport   227 AVES-QSLQVRRDTLGVLEAAVTRQ----PQLVNLILREALSASFTRD-----KLLPSKSTISTTEEQDQpiap------ 290 
XP_007328107   620 AVES-TRKDTRQATNKMISEAAVWD----PHLTTTLIRESVVASLCRA---------SSTKTTTGEDAPAlkk------- 678 
XP_001829939   649 AVES-KSPENRKLVNEYIVGLATAY----PQLTNTVIREAVTSFVSAT----------SSSSTSSPSPPStvppktepee 713 
XP_007398289   644 AVDG-SSVEIRRLAVSSMNAQAPKL----PEVVNRIVSASLKAYLVKE---------SAPARTSGEEAETkvvs------ 703 
9_pfamImport   227 AVAS-SSPNIRRLVVKALEEQSSAS----PELVNNAITAALTSYLTKE-----VATPSKLANRDGEESAPdsgr------ 290 
XP_024338474   644 VINS-PLPQTRRETLKTLEESVAQL----PEVASVAIVSALSAYVSKE-----KASSAKVQNGSSEENEPkvnr------ 707 
14_pfamImport  228 VVSG-QHQLVRRRTLATLEASAALF----PEIVNQAAISALSSFLSND--------KSSSATSSSEETSStshl------ 288 
8I9X_LR        656 -----------LHLVLKAICLspaelnrrSGGDVDKAQLQAQMCSLLVLAKQQLIP----RA-SWIDLCLKVQVDPGQLA 719  Thermochaeto...
15_pfamImport  294 --------aprFRPILLALAQ--------FEDEVEPTQREELLTRLVVLAHHPRITs--gSSaVWVDMLLRAGLAPEKVV 355 
3_pfamImport   283 --------------LLSSA----------NLANQVEEVKEKLIVDLFLVSHHPVLSr--aGEaLWIELAQHAQLDPHLVV 336 
2_pfamImport   291 -------nqrqFASLLLCCAS--------LNEQVDLAVRETLLVELIALGHHPLISgq-sRQ-LWIELCQKAHVDPYDLV 353 
XP_007328107   679 --------hsrLASVLLSSNT--------YDGDVDMELKEELVTELIVVGHHEFVSgp-lRQ-TWIDICQKANIDPKALI 740 
XP_001829939   714 aglqgwnkhgrLSGLLLSCSA--------FDESVSGLEKEGLVAEWVVVAHHPLICgp-sRQ-TWIDLCMKAGVDPLVVA 783 
XP_007398289   704 -------kegrLCAFLISCAA--------VGQDVDCSVREDLVLDLLVVSYHTAIAghglRT-PWIDLCQTAGVDPHEIA 767 
9_pfamImport   291 --------enrLSAVILSCGA--------MPADYDQDLKAQLMIKFVILAHHSAVCgk-sRQ-TWIELCQKAGVDPHDLV 352 
XP_024338474   708 --------egrLSAFLLAAQA--------FSEECDSATRKTALVRCVVLAHHPALGvg-sRQ-IWIEACQKGRVDPLNLV 769 
14_pfamImport  289 --------gdrLAVFCLASFA--------SRGSCEEQARKSSLVNFVVLAHHPAVGgk-sRQ-LWIDLCQKARIDPHDLL 350 
8I9X_LR        720 KD 721  Thermochaetoides thermophila DSM 1495
15_pfamImport  356 EN 357 
3_pfamImport   337 TR 338 
2_pfamImport   354 GR 355 
XP_007328107   741 EK 742 
XP_001829939   784 NK 785 
XP_007398289   768 TK 769 
9_pfamImport   353 YQ 354 
XP_024338474   770 VE 771 
14_pfamImport  351 SE 352 
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