Conserved Protein Domain Family
SCAI

?
pfam12070: SCAI (This model is not part of the current CDD release)
Protein SCAI
SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.
Statistics
?
PSSM-Id: 520059
Aligned: 26 rows
Threshold Bit Score: 659.38
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q54YY1                      67 HLLRKSQRLFIGLRDLPQFG-RQ-----WQPFFQKTFELYTKLWKFQQQYRSILEDKskyGLKRCEIGEIASKIGQLYYH 140 D...
EFJ38222                    11 ALVDKAYNKFSRLRDFPPYGqNK-----WDFYFRKAFQVYTKLWKFQQDNRQKLVEA---GLKRWEIGEIASRIGQLYYI 82 
XP_004957070                14 ALAEAADRKFARARDLPLYGgGD-------HHSRKAFKAYTRLWRLQQERRRELVAG---GLRRWEIGEVASRIGQLYYA 83 
Q94BN1                      12 ALVENADRKFARVRDLPAFGrAQ------SHYFQKVFKAYMKLWNYQQSHRSKLVES---GLNRWEIGEIASRIGQLYFS 82  t...
Vitvi:Vitvi012983.t01.CDS1  12 ALVESADQKFARVRDVPTYGrGP------NHYFQKVFKAYTRLWQYQQENRLKLVEA---GLQRWEIGEIASRIGQLYFG 82 
XP_006838589                13 SMCNKADRKFAKSANLPLYGkIN-----HASSFKKVFKIYTKLWKYQQDHRQKLIED---GVKRWEIGEIASRIAQIYFT 84 
EEF38372                    33 SLVERADKKFSKIRDLPYYErNR-----YDTYFYKVFKVYTQLWKFQQENRQKLIEA---GLKRWEIGEIASRIAQLYYG 104
XP_009134734                18 SLVNKADKKFSKIRDLPFYErSR-----YENYFFKVFKVYTQLWKFQQENRQKLVEA---GLKRWEIGEIASRIAQLYYG 89 
XP_006576669                35 TLVDKADKKFSKIRDLPFYQrSR-----HDTYFYKVFKVYTQLWKFQQENRQKLIEA---GLKRWEIGEIASRIGQLYFG 106
XP_003525043                14 ALVESADRKFGRVRDVPAYGgGAsqqqqQHHAFQKVFKAYTRLWKYQQENRAKLVEC---GMKRWEIGEIASRIGQLYFG 90  s...
Q54YY1                     141 YYLRTSDTNYLNESYIFYEAIRLRSYFKDVSLDK------TPDMMV--KQLRYYARFIVVCLLLNKKKVVFDLIEELLKH 212 D...
EFJ38222                    83 YYLRTSDATFVKESYIFYEAILSREYFKEP----------GKDITLanKQLRYFARFIVICLLLNRWDMVNRLVRQLHIL 152
XP_004957070                84 RYLRTAEPRSLVGAYVFYEAIYSRGYFGAAAGAEgggggrHQALLIryKELRFIARFLVVAMLMRRAEAVDHLAGRLRAL 163
Q94BN1                      83 QYMRTSEARFLLEAFVFYEAILKRSYFDEAQ---------GKDLGArfKELRFYARFLLVSLIVDRKQMLLHLADKLRLL 153 t...
Vitvi:Vitvi012983.t01.CDS1  83 QYMRTSEARFLLESYIFYEAILNRGYFQGSKGS-------MKDLGVrfKELRFYARFLLVSLLLNRSEMVRVLVERFRAL 155
XP_006838589                85 QYMRTSEMNLLCESCRFYQAILEREYFKENS---------ASDLSVanKQLRCYGRFLTACLTLGKREMVHQVVNHMKSL 155
EEF38372                   105 QYMRTSDAGYLSESYIFYEAILSREYFKEGL---------FQDLNLanKQLRFFARFLMVCLVLNRREMVHQLVNQLKLL 175
XP_009134734                90 HYMRTSDAGYLAESYVFYEAILTREYFKDGL---------FQDLNIanKQLRFLARFLMVCLVLGRREMVHQLVEQFRRL 160
XP_006576669               107 QYMRTSDANYLSESYIFYEAILTREYFKEGL---------FQDVNIanKQLRFLARFIMVCLVLNRREMVQQLVNQLKVL 177
XP_003525043                91 QYMRSSECRFLVEAYVFYEAILSRRYFQGSEPN-------AKDLGVrsKELRFYARFLLVSVILNRTEMVKHLVERFGAL 163 s...
Q54YY1                     213 VNDYTKIYKPS--DAQEWSLVLQEIFSFLQADQCATFSDTNQspsltnsgniinnnsnsnnnngehtNNTVQSHrlnhln 290 D...
EFJ38222                   153 VEDYSSSFQNS--DVKEWKTVTQEIVRFLKADSLAELSRPIR-------------------------YISALDG------ 199
XP_004957070               164 VEETKAAYPKT--NFKEWKQVIQELGRFLKADGAYKGSRSLR-------------------------YDNLFDS------ 210
Q94BN1                     154 VDHSISNFRET--NFKEWRLVVQEITRFIESDTNLTYLRPLR-------------------------YCAMLDS------ 200 t...
Vitvi:Vitvi012983.t01.CDS1 156 VDDCKVTFRETknNFREWTLVVQEIVRFMKVETAFMNVRPLR-------------------------YCNLFDS------ 204
XP_006838589               156 LDEHKRNFQDF--SYNDWKRMLIDINRFLKADTAFMNRRPLR-------------------------YSVVLDA------ 202
EEF38372                   176 VDECRRTFQET--DFKEWKLVVQEIIRFLKADSAFMNIRPLR-------------------------YSLVLDP------ 222
XP_009134734               161 IDECKRTFQEN--DFKEWKVVAQEIVRFLKSDTAFMNIRPLR-------------------------YSLVLDP------ 207
XP_006576669               178 VDECKRTFQES--DFKEWKLVVQEILRFLKAETAFMNIRPLR-------------------------YSLVLDS------ 224
XP_003525043               164 VEDCRTTFRET--NFKEWRQVVTEINRFTKVDKGFS-FRPMR-------------------------YCATFDT------ 209 s...
Q54YY1                     291 CPsp-pfPLESTQI-----LQQAILVGSQQNQIKFSEITLDMFRMTQSLEYEPmseakendmklkqqltalqqqqqqqaa 364 D...
EFJ38222                   200 QVss-fpSVSKLEGhkalrLKNAVLVSYFHNEVKFSELTLDNFRMLQCLEWEPs-------------------------- 252
XP_004957070               211 YPsn-laSIARFHSkrvlkLKEAVLTSYHRNEVKFTELTLDTFRMLQCLEWEPt-------------------------- 263
Q94BN1                     201 YPas-qtYLARFHAkklfkFRDALLASYHRNEVKYAEVTLDTYRMMQCLEWEPs-------------------------- 253 t...
Vitvi:Vitvi012983.t01.CDS1 205 YPss-vpYVARFHAkkmlkFRDALLASYHRNEVKFAELTLDTYRMLQCLEWEPs-------------------------- 257
XP_006838589               203 DPya-lpSVSSIEGkralrLSDAILGSYHHNEVKFAELNLDLFRMLQCLEWEPs-------------------------- 255
EEF38372                   223 HPds-llHVVTrrn---lrLRDAILTSYHHNEVKFSELTLDTFRMLQCLEWEPs-------------------------- 272
XP_009134734               208 NLdastpRAsrs-----lrLTDAILSSYHYNEVKYSELTLDSFRMLQCLEWEPs-------------------------- 256
XP_006576669               225 HPdt-lpHVAAAITkrhlkLRDAVLSSFHPNEVKYSELTIDTFRMLQCLEWEPs-------------------------- 277
XP_003525043               210 HRas-lpYVARFHAkrvlkFQDALLTSYHRNEVKFAELTLDIYRMIQCLEWEPs-------------------------- 262 s...
Q54YY1                     365 eakeknNGTDQQNttipsqplqqhlhhqqqqqqnGNg--------------SGIKKRNPHKYLLYRPTISQILLFLSYSF 430 D...
EFJ38222                   253 ------GSFYRMKsat---------------dsnAGglla-------qdiaDPTLPANPHKYILYRPNIHQLLMVLATAC 304
XP_004957070               264 ------GS-YQIAakelte---------ngtvsdQSgpsglidihlsteisDGSLPSNPQKAIIYHPTVSHLLAVLATIC 327
Q94BN1                     254 ------GSFYQKKpveake---------ngfvvdHTltsglidmnlaadmaDPSLPPNPRKAILYRPTVSHLLAVLAMIC 318 t...
Vitvi:Vitvi012983.t01.CDS1 258 ------GSFYQKRqvelnekl-----nengaltdHSgtsglidinlvvdmtDPTLPPNPRKAILYRPSVTHLIAVIATIC 326
XP_006838589               256 ------GSFYPKRlvess-----------esscgEAgaavpkrfsyieglvDHSLPPNPRKAILYRPAATQFISVLAAIW 318
EEF38372                   273 ------GSFYQSNsik----------------ygQNggpgpsrinythditDPTLPPNSRKAVLYRPSITHLLAVLGMIC 330
XP_009134734               257 ------GSLYQSAgpk----------------mgPNaptgasr-vnsqnvtDPTLPPNPRKAVLYRPSITNFLALLATIC 313
XP_006576669               278 ------GLFYQSSgsk----------------lsQNgatgtsrisyiqdiaDPTLPANPRKAVLYRPSLTHFIAVLATIC 335
XP_003525043               263 ------GVFYQKHtvkpke---------ngdiidHSgasgiidmnltadmtDPTVPPNPRKASLYRPSVTHVIAVLATIC 327 s...
Q54YY1                     431 KELGDNKAMLLYICADGFTNEDNhvnqhiqpppsiqqetvpsliddsntnipitttATATnplynKLFTKGLTLNMQKPS 510 D...
EFJ38222                   305 EEVPPDSAVLLYLSAAG---------------------------------------TRNFlasstDSSPDRSDALLEETP 345
XP_004957070               328 EELSQDSILLIYISASGCAEQNM---------------------------------ASQKyasssSSHATAASAFPIDKP 374
Q94BN1                     319 DELSPETVMLLYLSASGGPARENv-------------------------------aQPENsvgssRTSKSKLLARASQEQ 367 t...
Vitvi:Vitvi012983.t01.CDS1 327 EELPPDSVMLVYLSASGKSGRGNi-------------------------------sQMENsggtrKSSKVKVVSEISHEL 375
XP_006838589               319 EDLAPDGILLIYLSAAGKATSSSsglpl------------------------ssteQNPGdmqahDSVSDGNSISPESSS 374
EEF38372                   331 EELPADGVLLIYLSASGRVGQTIsspva-----------------------gtsitTADNvvrnlYSDTASts------- 380
XP_009134734               314 EELPSNGVVLIYLSASGKIGQTSlsplgg----------------------rsvtsVEENilrdfESHTIKQDGDPSVQT 371
XP_006576669               336 EELPSDGILLVYLSASGYCGSAQnesgcihf------------------------------------------------- 366
XP_003525043               328 EELPPDCVVLVYLSASGKAGLNNv-------------------------------sQVENfsgssKYSRHKVLSQTSQGQ 376 s...
Q54YY1                     511 qaiNSPTvnnNnnntTTnvtvptttttatnvtaqttttttttnstststtsnipiykyneapfntkvESLYPMDLLPFCR 590 D...
EFJ38222                   346 vsaGSPRrrvdgstg---------------------------------------------lslgrrgSNVYPGDLLPFTR 380
XP_004957070               375 nshMSSDnhlrlgp-----------------------------------------------rgsggpNNLYPEDLIPFTR 407
Q94BN1                     368 ksyKSEPhsnGklmsAEyyenhlwlg---------------------------------prggssgsNNLYPGDLIPFTR 414 t...
Vitvi:Vitvi012983.t01.CDS1 376 dssMPEApvnNkghsSDchenflclc---------------------------------pkgnggsnNNLYPGDIIPFTR 422
XP_006838589               375 rdsPTESrnlHeenhHNgsrgclrl----------------------------------ssrgneglNNLYPNDIIPFTR 420
EEF38372                   381 --pFSSPsncPnpssRRckgdclyf----------------------------------gargngglNSVYPTDLVPFTR 424
XP_009134734               372 kpsGERPgqsLrqisEDavehglsf----------------------------------gshgltgpSCIYPSDLVPFTR 417
XP_006576669               367 -----------------------------------------------------------gprgdrgsNCIYPSDFVPFTR 387
XP_003525043               377 nsePSETqnnGkrelSyydnylwf-----------------------------------gpkgnsgsNNLYPGDLIPFTR 421 s...
Q54YY1                     591 KPFFLIVNSQSSDIFNEL--PTFNQPFVSLLSPQSIPKKLV-SNLKC----GNLFTFFLHDPISAFCDISCGN--KIPSK 661 D...
EFJ38222                   381 RPLFIIVDSDASNIFESLcgDERGEPVVLLLSPTAKP-----YTAKHpg-aGSTFTFFLTAPLQALCQMTNVRvtELQQG 454
XP_004957070               408 YPLFLVIDSENSHAFKAIhnAEKGEPAALLLSP-RISSAMSgVESTGh---GSQFTYFLTAPMQAFCQLAGITs-DIDTD 482
Q94BN1                     415 KPLFLIIDSDTSRAFKVLggAERGEPVAMLLSP-LKPSFENpSTDDTealnGSQFTFFLTAPLQAFCQMLGLSntKPDPE 493 t...
Vitvi:Vitvi012983.t01.CDS1 423 RPLFLIIDSDNSHAFKDLhgAERGETAALLLSP-LKPAFKGpFGFDTtq-nGSQFTFFLTAPLQAFYELVGLSfsDTDSD 500
XP_006838589               421 RPLFLIVDCDSSHAFKAIsgAEMGETVALLLSPTLPSPCAAdADSTSqpnnGSQFTMFLTAPLQAFCLLVGVPgfNLGMD 500
EEF38372                   425 RPLFIVIDSDVSEAFKASvgSEKGEPAAILLSPSCSTPLTAv--ESSrhqsGSLFTLFLTTPLQAFCLLIGLSgsDIEMD 502
XP_009134734               418 KPLFIIIDSDNSTAFKNIcgAEKGEPAALLLSPSHTPPLISa--DFSrqpsGSLFTIFLTAPVQAFCLLIGISgsDIETD 495
XP_006576669               388 RPLLLVIDNDNSKAFKVIaeAEKGESVAMLLSPSCSPALS----DCShnsnGSLFTMFLTAPLQAFCMLLGLSgtDIDLD 463
XP_003525043               422 KPLFLIIDSDNSHAFKVLhgAERGETAALFLSP-LRPIFKNpSDVNSn--nGSQFTFFLTAPLSAFCQMIGLSpnESDTD 498 s...
Q54YY1                     662 TFNNISLLAQNSLEIISKLLFECVdLHPSFSFFLLDDFLRSFIIRFIFCHATFYLHKE-F 720 Dictyostelium discoideum
EFJ38222                   455 SYEQAEKMVSSTLLELGNLLASSGsLNVAWGRVLGDPFLRQLLFRFVFARACYSLHRL-Y 513
XP_004957070               483 TYANAENILFSALEEYEGILCTSVgLNNVWGQVVPDPFLRRLILRFIFCRAVLFYFHPeD 542
Q94BN1                     494 LCDEAESILSASFSEWETILLTSKvLNLVWAQVLPDPFLRRLILRFIFCRSVLTSFSR-T 552 thale cress
Vitvi:Vitvi012983.t01.CDS1 501 AYNDADKILSTALSEWEVILCTSTsLDLVWAQVLSDPFLRRLILRFIFCRCVLSLFCPpE 560
XP_006838589               501 AFNKVDEMLSSSFDEWGKMLADSEsLDPVWAHVLTDPFLRRLILRFIFCRGAISLYAPtS 560
EEF38372                   503 TYNKAEALLSSSLNDWGSALATSDtLDPVWAQILGDPFLRRLLVRFLFCRAVLTLFGPsF 562
XP_009134734               496 VFTKAERVLSSSMNEWASTLAASDtLHPVWSQILKDPFLRRLLLRFIFCRAVLALYTP-V 554
XP_006576669               464 TFNKAEMLLSSSLNNWGLALATSDtLNPVWGQILGDPFIRRLLLRFIFCQAVLTLYAPvY 523
XP_003525043               499 VYNEAENIIANALTEWEIILCSSTtMDLVWAQVISDPFLRRLILRFIFCRSVISFFCPpE 558 soybean
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap