Conserved Protein Domain Family
DUF3544
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pfam12064: DUF3544 (This model is not part of the current CDD release)
Protein kinase C-binding protein 1
This is a domain found predominantly in eukaryotes and associated with pfam00628 pfam01753 pfam00439 pfam00855. Family members include protein kinase C-binding protein 1 (also known as ZMYND8) which acts as a transcriptional corepressor of the H3K4 demethylase JARID1D. ZMYND8 (zinc finger and MYND [myeloid, Nervy, and DEAF-1] domain containing 8) binds acetylated damaged chromatin, including actively transcribed regions, as a means of recruiting the nucleosome remodeling and histone deacetylation (NuRD) chromatin remodeling complex for transcriptional repression and DNA double-strand break (DSB) repair by homologous recombination (HR).
Links
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Statistics
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PSSM-Id: 520056
Aligned: 10 rows
Threshold Bit Score: 250.621
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_013130445  428 RRVSMTDMPRSPMSTNSSVHTGSDGEQD-VEKGN-RNP--ALHYSTGEESMDCTaspvsg----kmgpgGSVSGSPKPF- 498 
6_pfamImport    1 QRHPLGDGQRSPMSTNSSAHGGSDGEQEtADRTQtKSA--NSQSSAGEESTDCT---------------GNSLDSSKPPh 63  
4_pfamImport    1 RQPPVSDVPCSPVSTNSSAHTGSDGEQEaADKSQaKAT--AGQCSTEEESMDCTgt-------------rNSLDSPKTMn 65  
1_pfamImport    1 RRISMTDIPRSPMSTNSSAHTGSDGEQEgGEKSQaKVP--LPHQTGGEESLESTaspaap----rpgpaGSAVDSPKPFh 74  
XP_022533319  424 RRISMTDMPRSPMSTNSSVHTGSDLEQDaSERGT-KLQ--SSHCSAGEDSMDCTaspa----------sqkTTGSPKPV- 489 
XP_005162001  422 CRISVTDMPRSPMSTNSSVHTGSDLEQD--ERGA-KMS--SSHCSAGEDSMDCTaspa----------slkTSGSPKPL- 485 
XP_692886     445 RRISMTDMPRSPMSTNSSAHTGSDGEQEtAEKGHaKAA--LPHYSTGEESQDCTaspa-------ssraGSTLESPKPFh 515 
XP_029682499  450 RRLPLADMPRSPTSTNSSAHTGSDGEQEtADKSQtKVPvtNNQYSTGEESMDstaspah----prpgpaGSSLDGPKPFh 525  torafugu
XP_029682498  450 RRLPLADMPRSPTSTNSSAHTGSDGEQEtADKSQtKVPvtNNQYSTGEESMDSTaspahp----rpgpaGSSLDGPKPFh 525  torafugu
NP_001268709  174 RRISLSDMPRSPMSTNSSVHTGSDVEQD-AEK---KAT--SSHFSASEESMDFLdkstaspastktgqaGSLSGSPKPFs 247  human

XP_013130445  499 ----NPGLVpKQERTAGTGGILNLNLDRVKAEMDLKELSETVqq--qQQQQGVPAPPSTPKRPIRS-----LDKTIESCK 567 
6_pfamImport   64 s--qTPDTS-KQEKAPQTGSILNLNLDRSKAEMDLKELSETV-----QQKQGAAPALTSPKRQIKSrfqlnLDKTIESCK 135 
4_pfamImport   66 s--qAPGIT-KQERPPQTGSILNLNLDRSKAEMDLKELSETV-----QQKQGATVALTSPKRQIKSrfqlnLDKTIESCK 137 
1_pfamImport   75 s--tTPSTPiKQEKTPTTGSILNLNLDRSKAEMDLKELSETVqqqqqQQQQGPQASLTSPKRQIRSrfqlnLDKTIESCK 152 
XP_022533319  490 ----LPAPL-KQERTQTTGSILNLNLDRIKAEMDLKELSESVqq--qQQQQGASVVLTSPKKPTRS-----LDKTIESCK 557 
XP_005162001  486 ----LTTPV-KQERSSGTGGILNLNLDRVKAEMDLKELSEAVqqqqqQQQQGASVLLTSPKKPTRS-----LDKTIESCK 555 
XP_692886     516 s--pAPNTPvKQEKTPTTGSILNLNLDRSKAEMDLKELSESV-----QQQQGAQPSLTSPKRQIRSrfqlnLDKTIESCK 588 
XP_029682499  526 c--rPAGIG-KQEKTPPTGSILNLNLDRSKAEMDLKELSETV-----QQKQGVLPVLTSPKRQIKSrfqlnLDKTIESCK 597  torafugu
XP_029682498  526 c--rPAGIG-KQEKTPPTGSILNLNLDRSKAEMDLKELSETV-----QQKQGVLPVLTSPKRQIKSrfqlnLDKTIESCK 597  torafugu
NP_001268709  248 pqlsAPITT-KTDKTSTTGSILNLNLDRSKAEMDLKELSESV------QQQSTPVPLISPKRQIRSrfqlnLDKTIESCK 320  human

XP_013130445  568 AQLGIDEISEDAYKDVDHSDSEDSEKSDSSDSEYLSDEEHKPKSSAQEDKDK 619 
6_pfamImport  136 AQLGIDEISVDVYKGVEHSDSEDSDKSDSSESEYATDEESKSKPGQDSAAKR 187 
4_pfamImport  138 AQLGIDEISVDAYKGVEHSDSEDTDKSDSSESDSASDEEQNTKGDQDTANDK 189 
1_pfamImport  153 AQLGIDEISEDVYKGVEHSDSEDSDKSDSSDSEYASDDEQKPKSSQESSADD 204 
XP_022533319  558 AQLGIQEISDDVYRGVDHSDSDDSDKSDSSDSEYASEEEHGPKESNQDNGAH 609 
XP_005162001  556 AQLGINEISDDMCGGVEHSDSEDSDKCDSSDSEEMSDDEQKPKNTNHNNSVH 607 
XP_692886     589 AQLGIDEISEDVYKGVEHSDSEESDKSDSSDSEYGSEDEQKSKNGQNNKTTA 640 
XP_029682499  598 AQLGIDEISVDAYKGVEHSDSEDSDKSDSSDSEYGSDVEHKTKNNQDAAPTs 649  torafugu
XP_029682498  598 AQLGIDEISVDAYKGVEHSDSEDSDKSDSSDSEYGSDVEHKTKNNQDAAPTS 649  torafugu
NP_001268709  321 AQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDK 372  human
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