Conserved Protein Domain Family
BAG6
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pfam12057: BAG6 (This model is not part of the current CDD release)
BCL2-associated athanogene 6
This domain is found in large proline-rich protein BAG6 protein. It has a conserved SDL sequence motif. Human BAG6 is an ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. It functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation.
Links
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Statistics
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PSSM-Id: 520052
Aligned: 14 rows
Threshold Bit Score: 111.357
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A3KPW9        264 LVEVLSEVRRVEERLRPFMERTHSILGAATSADYNNNTQEREEDQRTLNLIGESLHLLGNTLVALSDLRCNLSAQPPRHL 343  zebrafish
XP_029344097  355 LRELIEELNKLNERLRPFYAMYCQFIGDDPQFDTIEGEHGSLRAQTVFNGVSEVMHFISHVYHAISDLRVALNRPPPRSF 434 
EFA01091      283 MAELLTTLNQLQTRFAPFLERYRHFMVEDPIIPQEN----VRQTQAMLTRVSEVLHFLGHAYHSLSDIIIRVRTPPPRPL 358 
XP_011262107  305 MAELLQRLINTQDRLRPYFERYCMLTRLDPLLPPGPGPNTVEESQRIVDGVSEILHFMSHACHALSDIIIDMSQPPRRNL 384 
EGI63063      331 I--LLQRLCNTQERLRPYLERYCMLTLLDPSLPPGPGSQNVEENQRIVDGVSEILHFMSHCCHALSDIIIDMSQSPPRNL 408 
XP_002046671  356 LASVFQRYRSVETRLSPFLDRYYEILQQDPNFEEQD-TAGRENAQRIYDRVSEALHYLSHAQHAISDLMLDLSQPGPRVL 434 
Q9VS83        350 LAQVIQHYRGVQARLAPFVDRYYEILQNDPTFEESD-TDGRENAQRIFDRVSEAFHYLSHAQHAISDLMLDLSQPGPRVL 428  fruit fly
XP_056673862  280 YVEVLQELQRVESRLQPFLQRYHEILGSAATTDYNNNTEGREEDQRVINLVGESLRLLGNTFVALSDLRCNLACAPPRHL 359 
XP_023185542  291 LAEMLSELRRVEERLQPFMQRAHSILETATAAEYNNNTE-REDDQRTLVQICECLRLLGNALVALSDLRLNLMSPVPRHL 369 
EDO43370      222 LADVLGELQEFSSQLQPSLNRYTSLLNSPAT------ENLLPSDDSLPDRIAETLHNLSHAYHALSDLSINIRAPEPRRL 295 

A3KPW9        344 HVvRPMSHYtSPVMMQsgl-phiPIPMNL-GSTVTMTSNSR 382  zebrafish
XP_029344097  435 QS-RPCLLQ-GTILHA-------AHSVTT-TSTAAPPSTQQ 465 
EFA01091      359 LC-RPILIQhSAVVQAg-----iPIQVEV-AQFNLSERPNN 392 
XP_011262107  385 RC-RPIIVQhSAILQPs-----iPIQVEA-HISLNGRSANN 418 
EGI63063      409 RC-RPIIVQhSAILQPg-----iPIQVEA-HISLNGRSANN 442 
XP_002046671  435 TC-RPILVEqSGYIRSn--------nIFT-PNLVATPLAEL 465 
Q9VS83        429 TC-RPILVEqSGYIRSnni--ftPNFLAPpSGIINEPFRNR 466  fruit fly
XP_056673862  360 HVvRPMSHYtAPMVLQqa---aiPIQINV-GTTVTMTGNGT 396 
XP_023185542  370 HVvRPFSHYsSPVSLPgavhhhiPVQMNL-GATVTVAANST 409 
EDO43370      296 SVlTPL-----------------SPHVGA-PNLLSSIFGGR 318
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