Conserved Protein Domain Family
DUF3535

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pfam12054: DUF3535 (This model is not part of the current CDD release)
Domain of unknown function (DUF3535)
This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 439 to 459 amino acids in length. This domain is found associated with pfam00271, pfam02985, pfam00176. This domain has two completely conserved residues (P and K) that may be functionally important.
Statistics
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PSSM-Id: 520050
Aligned: 118 rows
Threshold Bit Score: 223.669
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004363681   581 VWHRLVRFAlpivvSATRSLQKLEALVLSWMTLAITPQGIALNyQDLLLPSIAqlqaqqqrqqqrqsvkmqsfesqanlp 660 
10_pfamImport    1 VFTKFVRSC------PHEALSTCIPYIPMWLHLAFYPMSVPIP-PNMLLQQnipvsyfpls------------------- 54  
4_pfamImport     1 VWANLIVNS-----SLTALLNAACPYIGLWLAMTMQSDKIPYD-TSSIIQHiptg------------------------- 49  
Q9VF02         660 VWSNLIQHA-----DLGALLHAACPFVSSWICLSMQPPRLAFD-AGVLIRAggdvstpgst------------------- 714  fruit fly
EDW34152       676 VWSNLIEHA-----DLGALLIAACPYVSSWICLSMQPPKLAFD-PSVLIRAgsgggdpatgi------------------ 731 
XP_002070651   669 VWSNLIQHA-----DLGALLNAACPFVSSWICLAMQPPRLAFD-SAVLIRAcgggggvagdas----------------- 725 
XP_002053233   678 VWSNLIEHA-----GLGALLHAACPYVSSWICLAMQPPRLAFD-PAVLIRGSGgasdvaavsag---------------- 735 
EDV94950       687 VWANLIEHA-----DLGALLHAACPFVSSWICLAMQPPRLSFD-PAVLIRAvagggvdaatnas---------------- 744 
XP_049535166   705 VWNNLIVNA-----ELSALLHASCPYVSSWLCLAMQPVRLAFD-PSSLIFAkppshsgatnrerr--------------- 763 
20_pfamImport    1 VWNNLVVNA-----ELSALLHASCPYVSSWLCLAMQPVRLAFD-PGSLIYAkpnqpgggpnrerrp-------------- 60  
XP_004363681   661 ppppplasppppgpvvkrprkataaraPAPAEPPSASsASIVASYYGQLLIGNISDrsifdfAeVQRCRLAAFEAIAAVC 740 
10_pfamImport   55 -----------------vkiasylqlqSNFLSCNMGTpNEDDKRYIGGVCSNTPPSee-----yVMATREYVASLIGLVC 112 
4_pfamImport    50 ------------------------pnkVDNVSNMPNEtSIDIKYYIGGSESIPADQre---kN-AIRARHLGAEMLGLLS 101 
Q9VF02         715 ------------------srkrtprigDELGGNILAQsNASLKLYLGGSEATPLDVrd---aN-FMRARISSSRALGALS 772  fruit fly
EDW34152       732 -----------------psrrrtarigDDLGGGILAHaNAQQKLYLGGSEATPLDLre---aN-FMRARISSSRALGALS 790 
XP_002070651   726 ---------------stssrrripklgDDLGGSALAHsNATLKLYLGGSEATPLEVre---aN-FVRARITSSRALGALS 786 
XP_002053233   736 -----------------strrrnlrmgDDLGGVALAHsNAMQKLYLGGSEATPLELre---aN-FMRARITASRALGALS 794 
EDV94950       745 ---------------atnvrrrplrigDDLGGAALAQsNAMQKLYLGGSEATPSEQre---aN-FVRARITASRALGALS 805 
XP_049535166   764 -------------------rqfdsfesssgslsATHIgGQHQKLFLGGAETVPLELre---kN-VIRARCKASRMIGLLS 820 
20_pfamImport   61 -------------rqfdsfdtgggtaaCGAGHLSSSSgALHQKLFLGGAETVPLDVre---kN-VVRARCKAARMIGLLS 123 
XP_004363681   741 RHW-----------PSTA-----LAGIESTLRGLLSSTSFARRVAAGAILAEWATFDTLDVpssVVTTPPATLRPVLTQM 804 
10_pfamImport  113 CYGys-------ytNNDKvtngqAVDMETHLLYLMTSQSAVQRIVASIVVSQWWSEIAATKk--MHSTPPPTLYIAFFKI 183 
4_pfamImport   102 CYIikpapnicyvnEDESp----VTCYTKLLISNLESNVAMQQKMTSLVISEWCKLQK------LDSLASKILAEKVTDC 171 
Q9VF02         773 HYLvqpapgvvytpQTESp----TDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDE------PVRPGPPNLQEKLHQC 842  fruit fly
EDW34152       791 HYLvqpapgvvytpQMESp----TDLYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDE------PVRPGPPNLQEKLHQC 860 
XP_002070651   787 HYLvqpapgvvytpQMESp----TDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDE------PVRPGPPNLQEKLHQC 856 
XP_002053233   795 HYLvqpapgvlytpQMESp----TDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDE------PVRPGPPNLQEKLHQC 864 
EDV94950       806 HYLvqpapgvlytpQVESp----TDCYTKVVLGHLNAHSAVQRIVCGLIIAFWALDDE------PVRPGPPNLQEKLHQC 875 
XP_049535166   821 RYLvlpapgvdytpETESp----IDCYTKVLVGYLQSRSALQRLIASLVIAYWCGIDS------TIQPGPPVLQDRLRAC 890 
20_pfamImport  124 RYLvlpapgvtytpETESp----IDCYTKVLVGYLQSRSALQRLISSLVIAYWCSFDG------TIQPGPSVLQERLRAC 193 
XP_004363681   805 LEeagnttS--YVELTAFIEDMRTECGALLGTFAErgLPKESLSSagDC---RMYAPLHANELATTffqawtvhldafdt 879 
10_pfamImport  184 LEe-----SfyFSEISFQFTQVQSDMKAFLATLLS-----------------KRIDIQQWVGLKTCtfr---------fa 232 
4_pfamImport   172 MNr-----MiyYDEMSFSITKLIQDAHDFLSSLk---HYKLTTPQqlN----QLVTLEHIELLTGP-------------- 225 
Q9VF02         843 VSe-----YvyYDEVAISLTRLLQEAQDFIATLk---QNKIPINDfnNA---KILTLDQIEAVATT-------------- 897  fruit fly
EDW34152       861 VSe-----YvyYDEVATSLTRLLQEAQDFIATLk---QNKIPINDfnNA---KILTLEQIEAVATT-------------- 915 
XP_002070651   857 VAe-----YfyYDEVAVSLTRLLQETQDFIATLk---QNKIPINDfnNA---KILTLDQIEAVAFS-------------- 911 
XP_002053233   865 VSe-----YfyYDEVATSLTRLLQEAQDFIATLk---QNKIPINDfnNA---KILTLDQIEAVATT-------------- 919 
EDV94950       876 VSe-----YfyYDEVAMSLTRLLQEAQDFIATLk---QSKIPINDfnNA---KILTLDQIEAVATT-------------- 930 
XP_049535166   891 LNe-----YvyYDEVAILFTRLLQECRDYLATLk---QYKVAPPEyaEAgtpKVLTLDQIYQIATTgp-----------g 951 
20_pfamImport  194 LTe-----YvyYDEVGILFTRLLQECRDYLATLk---QHRVQLAEyeQL---KVLTLDQIYQIATAvg-----------g 251 
XP_004363681   880 tVIQHHQAQISQLAAQVLtpmaaqqlrQLEsqlrfkqqqiqrlvdqciSKRSRIQSAVAALEFNHERMHIKVLSALAFAL 959 
10_pfamImport  233 iYYPPHLYLIT----------------DLL------------------EQCNLLTKLADRALKVQLTLECRVKAFASQAI 278 
4_pfamImport   226 -ETGILISSQKLKPKIYE---------QLE------------------DRRLSLNQAHKHISSELISLTTSTKASLAGAL 277 
Q9VF02         898 --LSENLRSYPLKPKVLD---------MLE------------------ERRRSLQASYQQTTSEQSAYHVSAQAALAGAI 948  fruit fly
EDW34152       916 --LSDNLRSLTLKPKLLD---------MLE------------------ERRRSLQASYQQTTSEQGAYHVSAQAALAGAI 966 
XP_002070651   912 --LSENIRHFPLKPKVMD---------TLL------------------ERRRSLQASYQQTTTEQGSYHVSAQAALAGAI 962 
XP_002053233   920 --LSDNLRSYALKPKVLD---------TLL------------------ERRRSLQASYQQTTSEQGAYHVSAQAALAGAI 970 
EDV94950       931 --LSDNLRSYALKPKVLD---------TLL------------------ERRRSLQASYQQTTSEQGAYHVSAQAALAGAI 981 
XP_049535166   952 wSGEEVRVKHCLKPKTAD---------MLE------------------ERRRCLLSSHSATALEQTTLHISTQSSVSGAV 1004
20_pfamImport  252 wSADEMRTRYNLKAKVAE---------LLE------------------ERRRSLLGSHSATALEQTTLHVSTQSSVSGAV 304 
XP_004363681   960 IA----------MDPRPDKLNPIVRPLMDAVRKEQDEPLHWRAARGLAVLVDRCVDRTPSPNDKIVRAVAGMLAADAAHT 1029
10_pfamImport  279 VSavhssgekdeIWKLPAKLNPLIRPLMEGLKWDESPTIRNAVSSTLSLLIGLCRNRQPCPNPKLIKNLCNSMTSHAIPT 358 
4_pfamImport   278 TM----------LQCLPEKIRPIVKPLMESIKKESNEMLQRWSADHLAILMDLCINRSSCPNTTIINNLCSFLCVDPEFT 347 
Q9VF02         949 CA----------LHCLPDKLNPVVKPLMESIKREQCLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFT 1018 fruit fly
EDW34152       967 CA----------LHCLPEKLNPVVKPLMESIKREQCVQLQQLSAEFLVHLMDQVCDRNPSPNSKILKNLCTLLRSDADHT 1036
XP_002070651   963 CA----------LHCLPEKLNPVVKPLMESIKREQCVPLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDGDHT 1032
XP_002053233   971 CA----------LHCLPDKLNPVVKPLMESIKREQCVPLQQLSADFLVHLMEQVCDRNPSPNSKILNNLCTLLRSDTDHT 1040
EDV94950       982 CA----------LHCLPDKLNPVVKPLMESIKREQCLPLQQLSADFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDTDHT 1051
XP_049535166  1005 VS----------LRCLPERLNPVVKPLMESIKREECELLQNLSARYLSELLDQVTVRTPCPNNKIVTNLCTLLKSDPEFT 1074
20_pfamImport  305 VS----------LRCLPDRLNPVVKPLMESIKREECELLQRLSAKYLSDLLDQVTVRTPCPNSKIVTNLCTLLKSDAEFT 374 
XP_004363681  1030 -------------------PQLPTE-----------------GNPkqil------ddwELGIVTARHqreadlad----- 1062
10_pfamImport  359 lklftkgedfilerchvtrPTVa-----------------------------------QCGILTILR------------- 390 
4_pfamImport   348 -------------------PKIG--------------------TEdr---------ikYELILMHQK------------- 366 
Q9VF02        1019 -------------------PKLVMPle-------------tlKQTpvssev--inncvYYGILTLAL------------- 1051 fruit fly
EDW34152      1037 -------------------PMLVMPqqt-----------ltqIQGqpqntsgasssclYYGILTLTL------------- 1073
XP_002070651  1033 -------------------PKLIMPfh-------------tvMDTmastva--dsncaYYGIVTLTL------------- 1065
XP_002053233  1041 -------------------PKLLMPsrtflatrsstsvsvhdTCD-------------YYGILTLKQqqatggssggggg 1088
EDV94950      1052 -------------------PKLLMPaht------------llETRstatvs-gndlcdYYGILTLKQ------------- 1086
XP_049535166  1075 -------------------PKVPCPsk-------------llQQFdpnnt---tetnpYHGILTLIK------------- 1106
20_pfamImport  375 -------------------PRVLCPdq-------------elQHFdpant---ddsnpYHGILTLAK------------- 406 
XP_004363681  1063 ------------------------ataggrgsSTAVSKagdddvaaa--------------------------------- 1085
10_pfamImport  391 --------------------------------STDKLQ------------------------------------------ 396 
4_pfamImport   367 --------------------------------LLQNAEkllmkrtgqrgsgr---------------------------- 386 
Q9VF02        1052 --------------------------------QQTVTTtntrsgaggattptattaprgp-------------------- 1079 fruit fly
EDW34152      1074 --------------------------------QQAMTSgsgsnssggtrgtpttgtastgssr----------------- 1104
XP_002070651  1066 --------------------------------QQAVKSnstanrgpgsgsttagsgtptaprg----------------- 1096
XP_002053233  1089 gagtraggtalmptprgpgrppasealaaavaAAASKEis---------------------------------------- 1128
EDV94950      1087 --------------------------------QQQATRnnssssgnscganaraggaatstltpa--------------- 1119
XP_049535166  1107 --------------------------------QQQKSKdqttssgnsssnggagsaggsprgpgrppvv----------- 1143
20_pfamImport  407 --------------------------------QHQRCKesgggggggtssnsgtsgggsssrgpgrpaasstvaaaldls 454 
XP_004363681  1086 ----------------------qaiaissgaATSSSGAD--------------------------------IsAAIARDG 1111
10_pfamImport  397 -------------------------------SEVNSRKRkrnqidegtiylpnstkvlviiyvlgahflrlVkADISCGG 445 
4_pfamImport   387 ------------------ppihcdinveitlSDKDQEQK--------------------------------LnNNIQKRG 416 
Q9VF02        1080 ---------grpptgeilsatnatahielkaQQAKEAEA--------------------------------KqCRIQRLG 1118 fruit fly
EDW34152      1105 ------gpgrppaseilaaaaaasahvelkvQQAKEAEA--------------------------------KqCRIQRLG 1146
XP_002070651  1097 -------pgrppaseilanaaaaaatieqsvLLAREAEA--------------------------------KqCRIQRLG 1137
XP_002053233  1129 -----------------------------tqQIKEAEAR--------------------------------Q-CRIQRLG 1146
EDV94950      1120 ----prgpgrppaseilaaaaaaaasveistQQAKEAEA--------------------------------RqCRIQRLG 1163
XP_049535166  1144 aaanvaldlsssssnatpstphtdegtagstQENEETSR--------------------------------KhARTQRLG 1191
20_pfamImport  455 asssssaaaassssaatattnaaldellggpSESEEMQR--------------------------------KhARTQRLG 502 
XP_004363681  1112 AELVLRAASERFQNSIFSMLPRLWGL 1137
10_pfamImport  446 ATHCIQTICKMFGKDLFNKVPTLLEI 471 
4_pfamImport   417 ALYALQTICSYFGEHLQSKLPRLIEI 442 
Q9VF02        1119 AACAIEKLCRIFGEQIIEKVAVFQHL 1144 fruit fly
EDW34152      1147 AACTIAKLCSTFGEHILEKVTIFQQL 1172
XP_002070651  1138 SACAITKLCSSFGEHIVEKVPIFEQL 1163
XP_002053233  1147 AACAIAKLCSSFGDRIVEKVPIFQQL 1172
EDV94950      1164 SASAIAKLCSAFGERIVEKVPIFQQL 1189
XP_049535166  1192 ATAAITTICSHFGPLLPRKLPIVWQL 1217
20_pfamImport  503 ATAAITTICAQFGAQLPAKLPILWQL 528 
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