5YDR


Conserved Protein Domain Family
DNMT1-RFD

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pfam12047: DNMT1-RFD (This model is not part of the current CDD release)
Cytosine specific DNA methyltransferase replication foci domain
This domain is part of a cytosine specific DNA methyltransferase enzyme. It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties.
Statistics
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PSSM-Id: 520045
Aligned: 17 rows
Threshold Bit Score: 109.382
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YDR_B         50 YEALPQHKLTCFSVYCKHGHLCPIDTGLIEkniEL----FFSGSA-KPIY---------DDD----PSLEG-GVNGKN-- 108  human
1_pfamImport    1 IDELPRSMLHNWALYNSDSRLISLELLPMKacaDIdvtiFGSGVMtADDGsgynfdtdaNHS----SSGGSrSAEIDGmp 76  
P34881         78 VEDRPTRRLNDFVLFDSDGVPQPLEMLEIH---DI----FVSGAI-LPSD---------VCT----DKEKEkGVRCTS-- 134  thale cress
Q05KC4         84 DEPRQTRRLTDFILHDEYGVPQPVAMVEIG---DI----FVTGVI-LPSG---------ECD----DKEKGkGVKCDG-- 140  field mustard
XP_001415894   51 GQTLPMRVLDEYEFRDKFAEGKAVSVHGSRpnrVL----VLGRARkLEGGehg---lpsEVL----AAPLT-PQDKPPha 118 
XP_001419868  215 AHGGIIRLLDDFELVQCETTSASCDTRARRrciKFhedlFENPDVaATIRisg---rlrEVRsdalAPLGDdDEEDGGrq 291 
O74560          7 EKKRKTDLIEQVCVTNKAGELVDLE--DVLeygPY----SLTGILsSEKD---------EQE----PLFDE--SIVLGys 65   Schizosacchar...
Q8IKY8        794 VSNNFLDSINEYHIETSNNKRNIME----KngeDI----FISDIK-EDKDnnil--ikqEDF----EKKKKkKILNNKik 858  Plasmodium fa...
Q9M0S8        365 TRDLPCRTLHNWALYNSDSRMISLEVLPMRpcaEIdvtvFGSGVVaEDDGsgf---cldDSE----SSTSTqSNVHDGmn 437  thale cress
B1Q3J6        105 EVQRPCRKLIDFILHDADGKLQPFEMSEID---DF----FITALI-MPMD---------DDL----EKDRQkGVRCEG-- 161  Japanese rice
5YDR_B        109 --LGP------INEWWITGFD--GGekALIGFSTSFAEYILMDPSPEYAPIFGLMQE-KIYISKIVVEFLQ----SNSDS 173  human
1_pfamImport   77 iyLSA------IKEWMIEFGS--SM--IFISIRTDMAWYRLGKPLKQYAPWYEPVIK-TARLAVSIITLLKeq-nRVARL 144 
P34881        135 --FGR------VEHWSISGYE--DGs-PVIWISTELADYDCRKPAASYRKVYDYFYE-KARASVAVYKKLSkssgGDPDI 202  thale cress
Q05KC4        141 --FGR------VENWSISGYD--DGy-PVVWFSTELADYDCGKPATSYKKMYDYFYQ-KAFASVEVYKRVAksagGDSGV 208  field mustard
XP_001415894  119 lkLME------VHDWTIKY----GGdePELWLVTPRAWYKLLNPAPRFEKYVTVTTR-RANFTNAIVRALVkn----wEL 183 
XP_001419868  292 ieVGN------IVAYQYSFVAtvPEi-RGFYLVTSTATYKLLKPKATYSMLYNRSFQmRYDLARRTARALPrs----pRS 360 
O74560         66 ikISP------V--WTYNLKDvpEKetMSIWIVTPQRRYGILSPSSEYKAIYEQISE-KNRLFYLIKTKFKddmiSGTLE 136  Schizosacchar...
Q8IKY8        859 khLNSmnvriiIKEWYIDYVLypNSipYIYVISTNNNRYRLDKPLAQYFHIFTKVRQ-KFEITTRILKTLQvy----pNM 933  Plasmodium fa...
Q9M0S8        438 ifLSQ------IKEWMIEFGA--EM--IFVTLRTDMAWYRLGKPSKQYAPWFETVMK-TVRVAISIFNMLMre-sRVAKL 505  thale cress
B1Q3J6        162 --FGR------IEDWAISGYD--EGt-AVVWVSTEVADYECVKPAGNYKSYYDHFYE-KAQVCVEVYRKLArsvgGNPNL 229  Japanese rice
5YDR_B        174 TYEDLINKIETT 185  human
1_pfamImport  145 SFGEVIKRVSEF 156 
P34881        203 GLEELLAAVVRS 214  thale cress
Q05KC4        209 SLDELLVAVSRS 220  field mustard
XP_001415894  184 SLEEGLDIILGV 195 
XP_001419868  361 SLESIIPELLTR 372 
O74560        137 DYDNYIEVLKEK 148  Schizosaccharomyces pombe 972h-
Q8IKY8        934 SYNRLISYLTLY 945  Plasmodium falciparum 3D7
Q9M0S8        506 SYANVIKRLCGL 517  thale cress
B1Q3J6        230 GLEELLASVVRS 241  Japanese rice
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