Conserved Protein Domain Family
Metallopep

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pfam12044: Metallopep 
Putative peptidase family
This family of proteins is functionally uncharacterised. However, it does contain an HEXXH motif characteristic of metallopeptidases. This protein is found mainly in fungi. Proteins in this family are typically between 625 to 773 amino acids in length.
Statistics
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PSSM-Id: 432283
Aligned: 21 rows
Threshold Bit Score: 308.519
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6BJL3         1 MTITLNYQDNEIVSSPTVIISGRTST-GI----TQGIVQVVN--NDNRv---FPPQC--F-------------------- 48  Debaryomyces ha...
Q6BZW1        73 APKMLNVRNNDVMHERFVIVHGNAGP-KGldaiNCGNVVVTH--HLNE----FPSQR--F-------------------- 123 Yarrowia lipoly...
XP_001646139   6 SIEFFNLDDEAKLISPSLIIRGKCNE-DK----EAKTIKVEH--PQ------LPSLE--Y-------------------- 50 
XP_001644576   3 EIELFNLQENALVTSPCLIIHGKCSK-QN----GSKNIQVQH--PA------LPTLN--F-------------------- 47 
Q6FX10         5 SIELFNLRPNEELFSPCVIIHGSIGK-GQ----TASNIQVQH--PQ------LPPLT--F-------------------- 49  [Candida] glabrata
Q2GRM7         3 QLDNFPTDEVSEVYQRCVLVSGKCNT-ASaleqNDGHVLVET--GDRFgktlFPEQR--W-------------------- 57  Chaetomium glob...
Q2UIV0        26 PFRIINLSEGDLVHQTCVAVHGECPElDDaadtVFVSVSSSHmfNQ------EPQTVnhW-------------------- 79  Aspergillus oryzae
Q9US12         3 QIILDNISQNETVYNRFVIIHGRVGP-RAs--yCPQTINVKH--HENS----FPEQT--W-------------------- 51  Schizosaccharom...
Q7UR15        40 SIRVENHESDSEVRYSVVLLRGTVAA-DD----ASELTIVNT--NTPAg---SSPVK--V-------------------- 87  Pirellula sp.
EDO47397      63 AIEV-DLRNGQTLYHPLVLLEGDCHR-KKknekSKLYEKTQH--VDKFs---VSTKD--Kyssssamdhvlvetrtkctk 133
Q6BJL3        49 -EVNNGNFKALIHVSPNEkNKLKIEimdngrmnpfgfpeyshgKPQVVDKSELNINFNPLPQNKPVHLCVLVGKDSQGAY 127 Debaryomyces ha...
Q6BZW1       124 -PVADNYFKAFVHLAPGP-NQLCVTye--------------ypDNRQPVSTSLTLIYTPLLQDPPLHLCLILGRDSKGEF 187 Yarrowia lipoly...
XP_001646139  51 -PIHESTFRATVILTPGE-NRFTF-------------------TTNTGLQRIIKCHYTPMLQDQPVHLCLLLAKDSEYVF 109
XP_001644576  48 -PVIDNFFKATIILNPGS-NRLTF-------------------VTDTNISKVVTCIYSPQYQNLPIHLCLLVANDSPLEF 106
Q6FX10        50 -PVHDSHFKATIILTPGA-NRLTF-------------------ITDTNVSKVVDCFYSPLDQNVPVHLCLIVAKDSPLEF 108 [Candida] glabrata
Q2GRM7        58 -PMCHGNFKALLLLSPGL-NKITI-----------------------------TTQDDASTETPPLHLAILVAKDSPLLM 106 Chaetomium glob...
Q2UIV0        80 -PLHKGQWKALVMLAPGT-NTLIFKlh---------------hARRFLASLQINVNYIPLLQLPPLHLAVLVAKDSPLLI 142 Aspergillus oryzae
Q9US12        52 -VVTDLYFKAIIHVVPGD-NTILF-------------------TTDDGGKLELQVYYQLLVDNPFYCIAFIVGKDSDLSF 110 Schizosaccharom...
Q7UR15        88 -LTDGKRFKALVELSEGR-NAIRL-------------------EHGSASTSELILDFKPQTNPHYVRLIWMTDQSGETDF 146 Pirellula sp.
EDO47397     134 wPIVDDAFKALVVLIPGS-NLLKVKv----------------cLDGEWRHKELSLIYQPLQLERFVRVVYIKCRDSDGTF 196
Q6BJL3       128 DMPHYRLKr--GEPANLQTAIKKLKVGGRLMQSFTQDDMRSTGMSNRSFQFVEETVSNQGIFgy----tvDSPTPHQEIK 201 Debaryomyces ha...
Q6BZW1       188 QSQSYKKQ---IEGNSLDLAVKKMRMAGYMMSAFTNEIMLRNGFGNRTFRFHEEWDVDTLSNr-------ESKTCRSTIK 257 Yarrowia lipoly...
XP_001646139 110 DSTTSQKEk--EKGHGLDLAIKKLRCGARLMQAYTNEQMLRAGFGNRTFSFVEEFAKDTLFR--------SQSTMRSTVK 179
XP_001644576 107 DSPRSQKDk--EGGNNLDLAIRKLRIGGRLMQAFTNEQMLRNGFGHRTFQFVEEYTWDTQFQ--------TRQQMRNTIK 176
Q6FX10       109 DSPASQKAk--EGGNGLDLAIKKMRVGARLMQAFTNEQMLRNGFGHRTIRFVEEYTWDTQFA--------QRIAMRNTVK 178 [Candida] glabrata
Q2GRM7       107 DCPPAKFGgisSAHSDLSAAIAKFRMTAYMWQALTAEDLRAKGLGRRAFRLEEEWSTDTLSQrsq---qtPTAAAGTVPK 183 Chaetomium glob...
Q2UIV0       143 DCPPAKYGgisTAHSTIDAAISKLRMSAYMWQALTAEDFRQKGLGRRSFRLEEEWSANTTVQaghqattgTKSSMGSVAK 222 Aspergillus oryzae
Q9US12       111 DAPH-------GAKNDIDEGIRKLRCAAYLWQAFTAECMYRNGYGRRSFRIEESVQPDTMSCls----pwGTE--RLTAT 177 Schizosaccharom...
Q7UR15       147 AVPDDTVT---------QDYANRLRTAALLMQTFTAERMKDLGYGPRTFALERDD--------------------KGEVV 197 Pirellula sp.
EDO47397     197 QAPP-------GSSCDIDVARQKLAFNARLLQSFTAHNLYKHGLGYQTFRLEEDTEGEPLV------------------- 250
Q6BJL3       202 IHVLRSPKTVAELRDPNLAQQNSKGNNTGGLFSHALELIEKTPELsdkfkRLKTAVQCAVLYLDSHFDT----------- 270 Debaryomyces ha...
Q6BZW1       258 VHIVRSELSVAEINSPDYAQQNSSGKDTGKLFNIAYDALKRHGLPf---tQDEVEHRAACVFVDSEWNI----------- 323 Yarrowia lipoly...
XP_001646139 180 VHLLHSDRTVEEIRDHDVAQQNRQAKRSGALYEYAMEALVKYGGPf---tNSEKPVQAAVVFMDSHWDG----------- 245
XP_001644576 177 IHILRSDKSTKEIRDYDIAQQNPKAKDGGGLFGVAMDALKKYGGPf---tNSDKPVQAAVMFLDTHWDG----------- 242
Q6FX10       179 IHIVRSDKTTKEIRDPDVAQQNDKAKDQGGLFGIAMDALKKYGGPf---tQNEKPVQAACVFLDTHWDG----------- 244 [Candida] glabrata
Q2GRM7       184 IHLIRTEKTVAQLRDANLAQQNPHARHPDDLHKIFTAALLAHGAPf----TTHTRPVVAGLILDSHYNTpdttisptsph 259 Chaetomium glob...
Q2UIV0       223 VHIIRSDRNVAELRDADVAQQNPRGRDRDALHRYFEAALAKSGPPf----ESSCRPVVAGLILDAHYSN----------- 287 Aspergillus oryzae
Q9US12       178 INILRSDKTAEEIRSV----------PPDQLFHIAGDAVDKLHLP--------EPWHYMCMFLDTRYDP----------- 228 Schizosaccharom...
Q7UR15       198 VHTWKGDQDKQD---------YYAQAENNRWWQQVRRWINDE--------HPDPMAKNVVLAAYTRKDP----------- 249 Pirellula sp.
EDO47397     251 -HVFTTALCMEE----------ALALSGGQLYDRFHQELVNSS-------LYDKNCKLWAFMSFTRYNPplpee-fnekd 311
Q6BJL3       271 KLDMILAHAALGGGNSN-IKLAIFGSHGLHSWPASFPQLTPSFLDGTHLSINEVANDCNQCGTSWECLNITLGAFMHEIG 349 Debaryomyces ha...
Q6BZW1       324 KRQLITGHAALGGGISN-VRLAIFGGHALWTWPSCVEEMVPALLDNTMVDVREVANDSRQSGSAWEALNVSQGAFMHEIG 402 Yarrowia lipoly...
XP_001646139 246 --QFITGHAALGGGNDA-IKLAIFGSHGLYSWPTCMEDIVPYFSDATTVSTKEVANDNGQCGSHWECLTVTLGAFLHEIG 322
XP_001644576 243 --KLITGHAALGGGTSD-IKLAIFGSHGLYSWPPSMEQLIPYMLDSTEASTKEVANDCNECGTHWECLVVTLGAFMHEIG 319
Q6FX10       245 --KLIRGHAALGGGDAD-IKLAIFGSHGMYSWPTCMEQLIPYFTDETRASTKEVANDCNECGTHWECLNITLGAFMHEIG 321 [Candida] glabrata
Q2GRM7       260 HSPLILAHAALGSHDPRgLSLGIFGSHLTYAWPRFLDEVPACLLDPTPPG-DTVGNDNGECDSMWRACAVGQGAFLHEA- 337 Chaetomium glob...
Q2UIV0       288 EQSMIMGHAALGCHKPDgISLGIFGSHLTYSWPRFLEEVPVCLTDMTPTG-DTVGNDNGECDTMRGACFVGQGAFLHEVG 366 Aspergillus oryzae
Q9US12       229 STQKIRGHVALGGGTDM-HKLGVFGSHSLHSFPSALEYVVPVFSDARRIP-SYLANDANESSTIWECANIGIGAMLHELG 306 Schizosaccharom...
Q7UR15       250 RTGKMLGHTALGGAN-----LGLFGSASMFCWPRDIQSAMDVFQDGTEVDPTHVHDDSAFRGTIWALASTTIGATLHETG 324 Pirellula sp.
EDO47397     312 IPMYVKGHTALGGGS-----LALFGTGGLHTWASCIEEVWPCFTDTRMIDKRTLFDDSSRRGTYWANYATCLGAAMHELG 386
Q6BJL3       350 HLLGCPHQVD--GVMLRDYI-WWNRSFMSREVECLRTKSRGqlintNGIWPRV-CHWNRLDLIRFFYHDSFSLPVDakdp 425 Debaryomyces ha...
Q6BZW1       403 HLLGCPHQPD--GIMLRGYL-TWNRSFLAKEV----TLGKGf---hRPCLPADeCSWHRLDALRFRHHPSFRLPHE---- 468 Yarrowia lipoly...
XP_001646139 323 HSLGCPHQEY--GVMLRDYP-VFNRSFLTEEAFSTRTNSNGv---aSPIDPSTeCKWHHLDLLRFLYHPSFTLPEDyy-- 394
XP_001644576 320 HLLGCPHQEN--GVMLRDYT-RLNRSFLTQEAFSVRTKSYGa---kPPIYPKEeCGWHRLDMLRFLYHPSFTLPEDyy-- 391
Q6FX10       322 HLLGSPHQVN--GVMLRDYV-RFNRSFLTKESYSLRTNSNGa---kPPIFPKEeCTWNRLDLLRYLYHPTFTVPQDyy-- 393 [Candida] glabrata
Q2GRM7       338 ------------GIARVVFS-PLGKADEEEDKVS---------------------VSNPLKSLRYSYEELASRFGTk--- 380 Chaetomium glob...
Q2UIV0       367 HAFGAGHTT---GIMARGYSkAWAMNFVAHETNGTAENDA---------------KWDLQDALKFKSLPHFALPGDklvs 428 Aspergillus oryzae
Q9US12       307 HTLGCPHQPD--GIMLRSYP-IFNRSFTTREFECVRTGSKGl----APVLAKDeCSWHHLDMLRFFYHPCFKLPSD---- 375 Schizosaccharom...
Q7UR15       325 HAMGLPHCTDnmGIMTRGFD-HFHRVFTFADPPSKQNKQP------RKFSSEQeAYFSPVSASFLRWSPWFQLDDS---- 393 Pirellula sp.
EDO47397     387 HCFDLAHTPA--GIMGRGFD-DINLVFTLQTTLQKKSSSGS-----GKV------VYTRQICIRVTNKPSTALIRW---- 448
Q6BJL3       426 tygkvqsTTIIPDDnyegsyrTPTLY------NTPRGG--A-LIKSGSGIY 467 Debaryomyces hansenii
Q6BZW1       469 -------HFPAPG--------KPNLY------PVENGT----IAKATSGIY 494 Yarrowia lipolytica
XP_001646139 395 -----dpTFHRPSKiggfvnpRPAVY------PLGNET--C-KITSKEGIY 431
XP_001644576 392 -----dpSFMRPTRlnnpgiaEPSLY------PLGNGT--C-TINSEGGIY 428
Q6FX10       394 -----daSFMRPGRlgnfdypKPSVY------NQGNNI--F-TLTSKTGIY 430 [Candida] glabrata
Q2GRM7       381 ------gLRLKVTGmngkeysVDNIW--------------K-LFQRGTTSI 410 Chaetomium globosum CBS 148.51
Q2UIV0       429 ----ndfRLAHVRIevdfgldNPDIM------SMEGEHpeGlKVSCTAGLA 469 Aspergillus oryzae
Q9US12       376 --------PTYPSD-------IETNY------FVKGET--I-TFVNSTGIF 402 Schizosaccharomyces pombe 972h-
Q7UR15       394 -----------TGVsaksprsRPNV-------EVDEAAklV-RISSSAGIP 425 Pirellula sp.
EDO47397     449 -------LSSAPSQdnfkkhnPVVHWghdvcgPVGNCG--S-FAQPEQSPF 489
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