Conserved Protein Domain Family
CAS_C

?
pfam12026: CAS_C (This model is not part of the current CDD release)
Crk-Associated Substrate C-terminal domain
This is a C-terminal domain found in CAS family members. The CAS (Crk-Associated Substrate) protein family is a group of scaffolding proteins that play important modulatory roles in both normal and pathological cell growth regulation. They contain an N-terminal Src homology 3 (SH3) domain pfam00018 and a substrate domain (SD). The SD contains a large number of YxxP motifs, which when phosphorylated by Src-family kinases provide canonical binding sites for proteins containing SH2 domains such as Crk, Crk-L, CRKII presumed domain is functionally uncharacterised.
Statistics
?
PSSM-Id: 520033
Aligned: 29 rows
Threshold Bit Score: 184.892
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002932712  572 DGSLKSWMDDYDY-----VHLQGKEEFERQQRELL----EK-----ENIIKQGKPQLEQYQ-----------LNQFQQ-- 624
XP_046443605  681 QTDNNSTNDDYDY-----VNLESKAKFDQENEEVKrtlpHEmkrafDVLVAQSEDLPVLPT-------------AAN--- 739
EEC07253      631 KRDDDQWASDYDY-----VNLESKASVERENEEIKaalpAElglsfDKLLQQSQLIVEGVVqe-------ppALSCA--- 695
13_pfamImport   1 KQEGDLAEDDNDY-----VELQVS-TSKEPKENARpclpLFcf--sPAQAKQHSSNSG---------------------- 50 
14_pfamImport   1 KEETIQLSP----------NLPQREVESYQKRAPFnkarENyh--sPEVLKKNGTSAPe--------------------- 47 
5_pfamImport    1 KQETLQLAPNAEFklkkcIQLPQRENESYQRSTPFnkqrENdh--fPELVKKNKTNVCGQKlpnleekekhiSKQRVDkn 78 
3_pfamImport    1 ELAKC-------------IQLPQREIESYQRSAPFskqkESeh--sPELLKKNGTIIR---------------------- 43 
A5GFW5        591 KEEPVQWTPNAEFklarrIQLPQKEGESYQRKAPFqkqrASeq--pPELIEKNKTNACG-----------------Q--- 648 pig
12_pfamImport   1 EKQRADGIEDCDY-----SRIQVSETGIAAGTSKWfevkGNi---fSKISSGGKKIWHVEA-----------VRQIEH-- 59 
XP_064420236  640 kpqinpddldrfvmvartipddikrfvsiiiangkllfkqntnkqeiqqaqrlttekevrnqiakqvrnaemqksapvck 719 coelacanth
XP_002932712  625 ---LErEItapvendmtkwksshdSSLVPQEKRLL---------SFYANQCETLFISLLNAIDAFFNCMSSGQPPRIFVA 692
XP_046443605  740 ------------------------DQVSDNDRNVM---------EFYGSQAETYAVYLSNAIDAFILTLEHNQPPKVFVA 786
EEC07253      696 ------------------------ASLDQNDLQIL---------NFYGAQIDTHILFLTSAIDAFLATIENNQPPKVFIG 742
13_pfamImport  51 ---------------------------SGTEEKEL---------SSMSEHCRLYFGALQKAIGGFVGSLQDDQPPEKFIS 94 
14_pfamImport  48 ------QVssevpplt-qqnpgrkVHL--------------------SEHCRLYFGALFKAISVFHSSLSNSQPPEIFIT 100
5_pfamImport   79 kdfNNlNPstllpqplslqnpekkIHL--------------------SEHCRLYFGALFKAISVFTSSLSNSQPPENFIT 138
3_pfamImport   44 ----EpNPsslipqplsqqnpekrFHL--------------------SEHCRLYFGALFKAIGVFNSSLSNSQPPEIFIT 99 
A5GFW5        649 ------NPgsliprplsqqnpekrIHL--------------------SEHCRLYFGALLKAIGVLNGSLSNRQPPETFIT 702 pig
12_pfamImport  60 ---LE-HFqpwstfk---qgpatkMEL--------------------SNICRLYFGAVQKAISVFHQSLSRDQAPEVFIA 112
XP_064420236  720 tkdnkvkpniskenviedcdyvqlqASKPSETHGIptkkdvpskVHYSEHCKLYFGALHKALSVFKNSLSNNQPPEVFIS 799 coelacanth
XP_002932712  693 HSKFVILSAHKLVFIGDTLARQVVTQDICKRLMNSSNQLCELLKTIVMATKMAALNYPSSSSLQEMVDRVTELSNQAQLF 772
XP_046443605  787 YSKFVILNAHKLLCIGDTVHRNVVNAKLKASVLERSNQLCQGLQTCVQSTKKAGREFPSVVAVQGMIDSVLAVSKLAQNL 866
EEC07253      743 HSKFVVISAHKLVYMGDTVYRNVLNADVRAQVLQCSSNLCEALKGLISSTKKAALQFPSVAAVQEMVDSIVDVSHLANDL 822
13_pfamImport  95 QSKLVIMVGQRLV---DTLYREAHRKGSNQSLLCKSNHLCALLKQLAVATKKAALHFPDRQALHEAQEFATQLAQRAQHF 171
14_pfamImport 101 QSKLVIMVGQKLV---DTLCKETQEKDVRNEILCSSSHLCGLLKDLALATKNAVLKYPSPAALGHLQAEAKKLENHTRQF 177
5_pfamImport  139 QSKLIIVIGQKLV---DTLCKETQERDARNEILGCSSHLCSLLKNLALATKDAVLQYPSPEALRHLQAEAETLERHTRQL 215
3_pfamImport  100 QSKLVIMVGQKLV---DTLCKETQERDVRNEILCGSSHLCSLLKSLALATKQAVLKYPSPAALGHLQTEAQKLEQHTRQF 176
A5GFW5        703 QSKLIIMVGQKLV---DTLCKETQERDFRNEILCGSSHLCSLLRNLALATKHAVLEYPSPAALGHLQAEARKLEQHTQQF 779 pig
12_pfamImport 113 KSKLIIMVGQKLV---DTLCQEAIEKTNRNEILCGSSQFCALLKSLAVATKNAAMQYPSPEAMRELQDQVDGLSKYTQHV 189
XP_064420236  800 HSKLVIMVGQKLV---DTLCREVQGKDIQNDVLYSSSQLCSLLKNLALSTKKAAVQYPNPTAVQELQDRVQELSQHAEQF 876 coelacanth
XP_002932712  773 KLSL 776
XP_046443605  867 KTCL 870
EEC07253      823 KVSV 826
13_pfamImport 172 RLSL 175
14_pfamImport 178 RGTL 181
5_pfamImport  216 RQAL 219
3_pfamImport  177 RGTL 180
A5GFW5        780 RGTL 783 pig
12_pfamImport 190 GACC 193
XP_064420236  877 RSLL 880 coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap