Conserved Protein Domain Family
FAP206
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pfam12018: FAP206 (This model is not part of the current CDD release)
Domain of unknown function
This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.
Links
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Statistics
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PSSM-Id: 520026
Aligned: 41 rows
Threshold Bit Score: 175.155
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002899895 238 DIQESVAALAKLVRDEVRDANEICTQ-YTEVLLHVhhqlgtgeeaHSAEPSPSLDEIARWQDELSNRRQFLSYLQSLEED 316
XP_001314639 211 EVPKKLNAAKDRITTSIEGVNSLIIE-YNKALKDE-----------------NVPNAKRLTDELANRQQFNFFYEFLLTR 272
XP_018636893 149 DLPLSIEQEIEEGEKQIQELVKILLH-SPVLLAKA-------------GSETAEQDLALISAQHIYMTQLNAYRRALLTA 214
XP_029345808 222 ELRDSFKKVMMTTSWILQ-----CYKvYTEILAPIfv-------iRINFATVTIKKLNDYKTVLVFYLQYQKNLEIIKND 289
Q57VI3       214 KAELLMSSLREHIEKELEEAISACAR-YVAVLRSPst------pvEGSMREAICAEYHRQLQLLLNIRMAKQQLDTLNNQ 286 Trypanosoma brucei
XP_001987562 218 DLEMAQSNTNAGFNAALERLKNLCDRcQTAVSDQLqfn----ckeTQLLYRVPLEQLHRINQFTVTFYMLQRCLTALKRS 293
XP_002059457 218 ELQMAQSNTSAAFDAVLERLKDLSGKcQAAISEQLqfn----ckeTTLYYRVPLEQLQRINQFTVTFNSLMRCLLELQRS 293
XP_002004300 218 DLQMAQANTNAAFDAALERLKELSSRcQTAISEQLqfd----ckeTTLYYGVALAQLDRINQFTITFNMLMRCLVALQSS 293
XP_002063261 217 DLEMAQTNTEEAFHTALKQASQMRSFcQMAVEENIkid----andMTLSYRVPLERLQRLNQFSLMYAMFYRCLNTLHLS 292
XP_001959181 216 DLEMAQKNTETAFAASMEKANGVRNIcQALLEELVtid----smaETISYKVPLEHMDRLNQFSLTYCMLHRCLTTLNSN 291

XP_002899895 317 IAFSHEKVGTRLQMFQADMSALQNLVGART----------SLPKSHVYPLFEAVSHSWAELHQEHELLQ---ARARALRS 383
XP_001314639 273 LKDISVGVEKSTIEFDSIIENLRNQMEISD----------SVPTQKSMPYFAALAEVWHKLKGCEDQVQ---TIENLLAR 339
XP_018636893 215 FLHTRHHLKEAVSECMSEIVGVGEELNSQP----------CTSRDDVFPKFSRIAVSYRKAFQENEKLC---SLNCLVAF 281
XP_029345808 290 LNKLKIELPALLIKFNIILKEIKQ-LKNTN----------DFGEDTICPEFNNVTIIWSEIRGIMNHLS---ITCNLILT 355
Q57VI3       287 I------FGELLPSYEAALEAVKDVLGTRSmrsdgvslrkNVSKATVYPKFIELAEVYEEAQRSFQSFEdikALMTLSLS 360 Trypanosoma brucei
XP_001987562 294 YEHTAYLVSVETGRYECVVAKINDTLSMRT----------SIQSELIFPHFVYLSKVWSNLNHYFNHIV---ELNKLREQ 360
XP_002059457 294 YEHTAYMVSVESGRYNCVIAKINDTLYMRS----------AIDSELIFPHFVYLSKVWGNLNHYFNHIV---ELNRLREQ 360
XP_002004300 294 YEHTTYLLSVETGRYDCVVAKINATLAMRT----------SIESELIFPHFVYLAKVWANLNHYFNHIV---ELNKLRER 360
XP_002063261 293 YENTKYLVNVEQKRYQCVIAKINDTLSMRT----------AIESELIFPHFVYLSQVWTNLNNFLNHIV---ELNKLREH 359
XP_001959181 292 YQTTAYLIEVELKRYNCVVAKINETLSMRT----------AIESELIFPHFVYIAQVWGNLNNFLHHIV---ELNKLREQ 358

XP_002899895 384 LLRFKstftrtlsses-------pivrqarrggsIPPEDLFSHVETFPVEsQLAVdgktrsfglegedldgdeDNSNPSE 456
XP_001314639 340 LRKHRdtftysistvd-------etaptiptpqqTPPTEKEVIPKESEVAgDDS-------------------------- 386
XP_018636893 282 LASLAgehtldvasnvesacrrvhgifasvgqgdQEECRGVRSAENAEKErDDN-------------------------- 335
XP_029345808 356 MKQLTyeinniseei---------nnksimdtilTDTEELYTIFETYPLHpMCE-------------------------- 400
Q57VI3       361 LGKVS------------------------------NSSLPPTLLQEAINLeKEDGpadrcs------tearfeSIVTASL 404 Trypanosoma brucei
XP_001987562 361 LEQQVtkemahrakdt--------itqiqdlakrRKDWFECSFFERMDALkKYQt------------------------- 407
XP_002059457 361 LECQVpkemeqrakdt--------imeiqdlskhIKEMRECSFNERMELLkKYQt------------------------- 407
XP_002004300 361 VEAQItsgmvqrsket--------iaeiqelakrHSEMRKCSFNQRMDTLkKFQt------------------------- 407
XP_002063261 360 LESLIpmdikslaest--------vaeilairqrIKSDSVVSFDERMAALkMHQt------------------------- 406
XP_001959181 359 LEALVvddlvtmtknt--------iaelqalnkrIKTPKVVTFDERMNAVkGLKt------------------------- 405

XP_002899895 457 EE---GSGfpiRMPVES-TPEFMQL-PLD----YQGFCPWTVVERGGLLL--------PGDPSLGVVQYRN----AYHVF 515
XP_001314639 387 ------------------HPVLVQH-DADgefaFNGFCPVTLVERNGLLL--------PGDVVLGSIKWEK----RYYAF 435
XP_018636893 336 -----EVErpdGEPPR----------EFDgkfeLGGNCAWCLAKYAALV---------PADRSIAAISYGG----DAYAF 387
XP_029345808 401 -----------WHPPTTsTDDTRNL-FAD------GYCVVMIVETDGTLI--------KHDKSLGVIQYSD----EWFGF 450
Q57VI3       405 PTkldRVFy---------ARDAETLrARSavcaLNGMCPVTLLE-DGLCVegrvgsrdPAFPGFVMRSEVDnervEWYAF 474 Trypanosoma brucei
XP_001987562 408 ------------------DGNFCSLaKAD----IKEFCGLTLAVTNGLLL--------PAKVQRKLCMNVD----IKFGF 453
XP_002059457 408 ------------------DGNFCSLaEAD----IKEFCGLTLAVTNGLLL--------PAKVLRKLCMNLD----IKFGF 453
XP_002004300 408 ------------------DGNFCSLaQAD----IQEFCALAMAVTNGLLL--------PAKVVRKLCMNVD----IKFGF 453
XP_002063261 407 ------------------DGNFCNLaRAD----INEFCALTLTITNGLIL--------PAHVQRKLCMNVN----ISFGF 452
XP_001959181 406 ------------------DGNFCNLaKAD----IKEFCGLFMTMTNGLLM--------PAKVIRKLCSNMD----ITFGF 451

XP_002899895 516 VNERALGEFMIHPRRYVQGVLRRAGRQPALIYLLRLQES-FP 556
XP_001314639 436 VDQVKRNKFLADPQYWHDEAMKVAQKKPELVPLLGLQNE-FP 476
XP_018636893 388 STLRGAKEFAQHPDRLLSDIRQQIRRQPALIHLLNLDRLyPR 429
XP_029345808 451 ASIQAALHFGTKPTYYLYHFLNLMRSKTHLLSFFHLYEQ-MA 491
Q57VI3       475 QTASKLLRFAASSQRFVDHAKTLVKSNMVMVGLFGLVDLlPR 516 Trypanosoma brucei
XP_001987562 454 QDETYARIGELWFERFITALRQAIFNSANLALLFKLDDA-LI 494
XP_002059457 454 QDETYARIGELWFERFIIAFRQAIFNSANLALLFNLDHA-LI 494
XP_002004300 454 QDETYARIGELWFERFITALRQSIFNNANLVLLFQLDHIlIA 495
XP_002063261 453 RDHRFARYAELRFEQFIEAFRKVIFQNANLALLFHLDEE-LL 493
XP_001959181 452 RDPQFARFAELRFEHFIVAFRSAVFNSANLALLFKLDDE-LI 492
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