Conserved Protein Domain Family
Cyclin_D1_bind

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pfam12014: Cyclin_D1_bind (This model is not part of the current CDD release)
Cyclin D1 binding domain
Ubiquitin-dependent proteolysis of cyclin D1 is associated with normal and tumour cell proliferation and survival. The best characterised member of this family is the SCF FBXO31 (Skp1-Cul1-Rbx1-FBXO31) ubiquitin ligase complex mediates genotoxic stress-induced cyclin D1 degradation. FBXO31 possesses a unique substrate-binding beta barrel domain, whereas cyclin D1 binds to FBXO31 by tucking its free C-terminal carboxylate tail into an open cavity of the C-terminal FBXO31 beta-barrel. Biophysical and functional studies demonstrated that SCFFBXO31 is capable of recruiting and ubiquitinating cyclin D1 in a phosphorylation-independent manner.
Statistics
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PSSM-Id: 520023
Aligned: 93 rows
Threshold Bit Score: 100.38
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_019834542  114 YRRIYlP----PSrpddLIRP--GLFKGTYGSHGLEIVMLSF----------------------------------HGKH 153
TDZ17381      400 YSTLD-PvvyaPT----PLKPwrGIWVGDYSGHGCEFLLINQpdedeasdeelglvrga-degddewlrrrtdarvYRGR 473
XP_009648378  119 YSTLD-PalytPT----THKPwrGIWVGDYSGHGCEFLLINQpddkdatdqelglarna-sesdedwakrqlearvYRGR 192
32_pfamImport   1 YSTLD-PtlytPT----ATKPwrGIWVGDYSGHGCEFLLVNQpddppatdlelglergd-tesekewrkrwldariYRGR 74 
CCE29961      270 YSTLD-TilytPT----ESKPwrGIWVGDYSGHGCEFLLIHQpddpavtdaelglvrrv-detdeaweerrretyiYRGR 343
EMR71397      388 YSTLD-PilytPT----PEKPwrGLWVGDYSGHGCEFLLINQpdgvdedqtplvrged---eteasfqarflrervHRGR 459
XP_009227077  445 YSTLD-PalytPT----ADCPwrGIWVGDYSGHGCEFLLMHQihddadgerpeddivrepgetdedfearrrdarvYRGR 519
XP_003709864  474 YSTLD-PalytPT----PEAPwrGIWVGDYSGHGCEFLLLNQiitgteehdltreeg----ltdeefeakkeearkYRGR 544
XP_008077612  349 YSTLD-PslytPT----EEKPfrGIWVGDYSGHGCEFLLMNQpddeepfdetsvvqae--detvdewearkkiernYRGK 421
XP_007296612  526 YATLD-PklytPT----EEKPyrGIWVGDYSGHGCEFLLMHQpddpepfdeaslvqre--detpeefktrkfeekvFRGS 598
XP_019834542  154 ARGTKITGDPNIpagqqTVEIDlrhriqlpDA------ESLHDFNE-LSRVVLevreqvrkeqeqeqeggpedaeglgqq 226
TDZ17381      474 LEAIKLTGDPNVprgeyTFVAD--------DLgeagfvGVAQEPPFqGTRVVK--------------------------- 518
XP_009648378  193 LEAIKLTGDANVprgeyTFIAE--------DLgpegsaGVATEEPFvGARIVK--------------------------- 237
32_pfamImport  75 LEAIKLTGDPNIprgeyTFVAD--------DLgpagyvGDAQDELFaGARMVK--------------------------- 119
CCE29961      344 LEAIKLTGDPNVprgeyTFVAD--------DLgpegfvGIASDPPFtGTRIVK--------------------------- 388
EMR71397      460 LEAIKLTGDPNVprgeyTFVAD--------DLgengfvGVAQDPPFlGTRVVK--------------------------- 504
XP_009227077  520 LEAIKLTGDPNVprgeyTFVAE--------DMgpkglvEVLQEDPFkGVRMVK--------------------------- 564
XP_003709864  545 LEAIKLTGDANVprgepTFVAE--------DLgpggfvTVIEEKPFtGCRVVR--------------------------- 589
XP_008077612  422 LEAIKLTGDPNIprgqyTFVAD--------DIgsggfiRNATEERFkGARVVK--------------------------- 466
XP_007296612  599 IEAIKLTGDPNVprgeyTFISD--------DIsqagfiRNATEPRFkGARIVK--------------------------- 643
XP_019834542  227 spqpreeppaepaqapgdggaaavaeppaqsgqpfvlpvgvssrnedyprtcrmcFYGtgLIAGHGFTSPERTPGVFVLF 306
TDZ17381      519 -------------------------------------------------------SRG--HVAGTGFRDDKYIESQLMLI 541
XP_009648378  238 -------------------------------------------------------SRG--HVADTGYFSDKYIASQLFLI 260
32_pfamImport 120 -------------------------------------------------------SKG--HVAAAGFHRDKFIESQLILL 142
CCE29961      389 -------------------------------------------------------SRG--HVAGTGFVNDRYTESQLLLI 411
EMR71397      505 -------------------------------------------------------SKG--HIAAMGFFDDKYMESQLLLL 527
XP_009227077  565 -------------------------------------------------------SQG--HVAGSGFLDDKFIESRLLLI 587
XP_003709864  590 -------------------------------------------------------SKG--HVAQSGFNLDKYIESQLIMI 612
XP_008077612  467 -------------------------------------------------------SRG--HIAARMFRNPKYIESQLIMI 489
XP_007296612  644 -------------------------------------------------------SRG--HIAARMFRNDKYIESQLILV 666
XP_019834542  307 DEDRFGFIWLELKSFSLYSRV-QAA 330
TDZ17381      542 SHSRLAQYWVTFGHISYFERVnIDN 566
XP_009648378  261 SPNRLAQFWVDFGHISYFERVdIDS 285
32_pfamImport 143 SHNRLAQYWVGFGHISFFERVhIDE 167
CCE29961      412 GPNRLAQYWVEFGHISFFERVqIDQ 436
EMR71397      528 SHNRLAQYWVSFGHISFYERVnIDQ 552
XP_009227077  588 SHNRLAQYWLGFGHISFFERVdIDR 612
XP_003709864  613 SHDRLAQYWVDFGHISYFERVdIDR 637
XP_008077612  490 SHDRLAQYWVGFGHISFYQRVdIDQ 514
XP_007296612  667 SPDLLAQYWVGFGHISFFQRVdLDR 691
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