Conserved Protein Domain Family
NPH-II

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pfam12011: NPH-II 
RNA helicase NPH-II
RNA helicase NPH-II or I8 is found in Poxviridae. It is essential for viral replication and plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase. It acts as NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs. It might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm and is required for propagation of viral particles.
Statistics
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PSSM-Id: 288834
Aligned: 10 rows
Threshold Bit Score: 228.787
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q98218   2 KNLPGVFAFPDNETIFAHAYSQRELEAMlparAGAQPHAFAYAAWPLSKHRWRGAFVCR-QRGVLKLNLELDAG-AFERV 79  Molluscum contagiosum...
Q6TUW4   3 NHLPEIFYFPNCVDVFSHQYSQSEFDKM----EKDFKKGFSLSVFPIIKHRWKKSFVVM-DDGVLKLNLESSVNgNKIKK 77  Yaba monkey tumor virus
Q8V3P8   3 NHLPNIFYFPNCINTFPYKYSQIEFDKM----DKKEKMRFAYAVFPLIKHRWKYAYIIKdNNNVYKLNCESKQF-----Y 73  Swinepox virus
Q08FU4   3 NPLPNIFYFPNCVNIFSYHYSQVEFDSM----NITDKKRFSMAVYPLIKHRWKNCSIIY-NNRTYKLTCENKQYnNIENK 77  Deerpox virus W-848-83
P12927   3 KNLPDIFFFPNCVNVFSYKYSQDEFSNM----SKTERDSFSLAVFPVIKHRWHNAHVVK-HKGIYKVSTEARGK------ 71  Vaccinia virus WR
Q9Q927   3 NHLPNIFYFPNCVTTFPYRYTQKELDDM----KPDERERFKYATFPIIKHRWSHAYVVK-DNHVFKLNVETS-------K 70  Rabbit fibroma virus ...
Q9Q8Q2   3 NHLPNIFYFPNCVTAFPYRYTQKELDDM----KPVDRERFKYAVFPLIKHRWCRAYVVR-DNHTFKLNVETS-------K 70  Myxoma virus (strain ...
Q6TVT4   3 NHLPDMLMFPNCVSVFPFEYSLEDVFRL----PEERRRAFAMAVFPLSKHRWRGARLQRdERSVW-LSVEEDRGrALGER 77  Orf virus
O72904   4 NDLFSIYAFSNMYDIFPRKYSQKELEEY----HRKNPLFFSYTIFPVIKHRWSKAYICF-QNNVYMLNIELDTSkPYDRV 78  Fowlpox virus strain ...
Q070I0   1 --mlDLFAFPNNVDVFPHEYSQERLEEL----NAADPSAFSLAVFPVHKHRWADAYVVR-ARGVYRLSAEVRTA-----L 68  Crocodilepox virus
Q98218  80 PRSEa---eRFEPEQSDARALMHRGADgTVMSFECYSFLRCRPGL-ELREA--GLALLRGLVVGGNRMRIFSGVRRagaS 153 Molluscum contagiosum...
Q6TUW4  78 KIII-----TRYPESVNFKLKTYTIGN-LKITFECYSYLMCRQVT-DTNLF--DEYILRGLVEGGNALKIFSKKTG---H 145 Yaba monkey tumor virus
Q8V3P8  74 KEIIldnslISPPTKIYIKTKEYLMDN-IRISFECYSYIKIKQDTiDIHNM--DDFLLRGLLEGGNNLNIFTNCIG---H 147 Swinepox virus
Q08FU4  78 NVNHl---dINIPSKINIKKKEYTIGN-IKMSFECYSYIKSFSIT-DITLF--DEYILRGLLEGGNKLNIFSNIMG---N 147 Deerpox virus W-848-83
P12927  72 ---KvsppsLGKPAHINLTAKQYIYSE-HTISFECYSFLKCITNT-EINSF--DEYILRGLLEAGNSLQIFSNSVG---K 141 Vaccinia virus WR
Q9Q927  71 RLRRatpptLSVPVSMNTMLREYITQDgTKISFECYSYLTCKKAT-SLHDL--DDNAIRGLVEGGNRLQLFTNSVG---S 144 Rabbit fibroma virus ...
Q9Q8Q2  71 RLRRvayptLVPLVGVNAALREYVMEDgTKISFECYSYLICKRTT-SLHDV--DDSTIRGLVEGGNQLNIFTNSVG---S 144 Myxoma virus (strain ...
Q6TVT4  78 NCSWls-----------dvAARMVDDEgRAVTPEAYAFMRAAPGA-RVAELaaDAGVLAGLVAGGNALRVFSSESTqarE 145 Orf virus
O72904  79 PIQHl---iDIRPISTDIKKEIYKISDkTFITFECYSYLKCKGYN-SIYDI--TLDDKRGLLSAGNILSIFSSNKQm--P 150 Fowlpox virus strain ...
Q070I0  69 PEADaapleDFVPVRT---YADHHEAGgVKVSLECYSMLQCRRGL-RLADL--GLAVKRGLVAAGNRLGIFSAPVR---T 139 Crocodilepox virus
Q98218 154 --AATSAGMLGNESPFERAPFASLR 176 Molluscum contagiosum virus subtype 1
Q6TUW4 146 --VKSTIGIFGNDTPFLKVPLMSLK 168 Yaba monkey tumor virus
Q8V3P8 148 --RDNTIGIFGNIKPFSKIPFVSLQ 170 Swinepox virus
Q08FU4 148 --QNDTINIFGNPKPFSKIPLKSLQ 170 Deerpox virus W-848-83
P12927 142 --RTDTIGVLGNKYPFSKIPLASLT 164 Vaccinia virus WR
Q9Q927 145 --VKDTVGIFGNPNPFMKVPLKSLH 167 Rabbit fibroma virus (strain Kasza)
Q9Q8Q2 145 --VTNTVGIFGNPNPFAKVPLKSLH 167 Myxoma virus (strain Lausanne)
Q6TVT4 146 gwKARSVGVLGNAAPLAPVPLASLR 170 Orf virus
O72904 151 --EKSSIGILKNPKPFTVIKFKSLS 173 Fowlpox virus strain NVSL
Q070I0 140 --EATSVGRLGNARDFDRVPFRSLG 162 Crocodilepox virus
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