4O26,6ZD2,7SBE,5C9H


Conserved Protein Domain Family
Telomerase_RBD
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pfam12009: Telomerase_RBD (This model is not part of the current CDD release)
Telomerase ribonucleoprotein complex - RNA binding domain
Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.
Links
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Statistics
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PSSM-Id: 520020
Aligned: 113 rows
Threshold Bit Score: 76.398
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4O26_A        112 RVYLFVRECLTAVVPEELWGSDHNRLQFF-SRVRGFLKSGKFERISVAELMWKIKV--MDCdwLK--------------- 173  Japanese medaka
XP_002428028  334 IIFTYLIDIIRKVIPFYFFGSNNNLRKKFfNEIIKIFKMSSGENLNLFGFYQMLTKckKNLqwck--------------- 398 
XP_007604494  241 TIADFLFLISKKFLRPIL--SLKSFKTLK-GKLVLLLKRNAFETLNSEDLSNRFKM--SNFkfFNhc------------- 302 
Q8SQQ0        250 KLVNFLFLISKKLFKDAF--DLHGFRILK-SRLSLLIHRNRYETVSKNELVKYFRI--SRFkfFR--------------- 309  Encephalitozo...
EEQ82507       80 KLINFLFCVSKKVFLNIF--DRYNFRILK-QKLTLLIYKNKLESFSEEELIRHFRI--VNFrfFKnng------------ 142 
A0DPN6        293 QVISILRYFLRTIIPIDFLG-QSNLYTFL-KDLSQFITFLRFEDQNYLDYINRLNV--FQIp------------------ 350  Paramecium te...
O77448        375 QITNFLRQIIQNCVPNQLLG-KKNFKVFL-EKLYEFVQMKRFENQKVLDYICFMDV--FDVe------------------ 432  Tetrahymena t...
XP_001617069  741 QVVNFIVHITKKCVPVKLLGSRHNFKVFI-KNVKNFVLLNYKENFTMDQMMKHIRV--RSV--FQkgaphmqmknadvga 815 
Q4MZJ7        313 NVYKYIKSIVEQTVTPELLCGNSNYLKFL-KVCYSLITLNKGENLSMSEVMKGFKI--KDCvwtgrg------------- 376  Theileria parva
5C9H_A        162 QITNFLRQIIQNCVPNQLLG-KKNFKVFL-EKLYEFVQMKRFENQKVLDYICFMDV--FDVewF---------------- 221  Tetrahymena t...

4O26_A        174 ----------------------------L--------------RRTAG-RFP--PS-----------ELAYRTRILSQFL 197  Japanese medaka
XP_002428028  399 ----------------------------------------------------------------emnNDEIENVMLIKTL 414 
XP_007604494  303 --------------------------knLs-------------N-------------------------STRIQVLKNLM 318 
Q8SQQ0        310 -----------------------------------------------TlRCT--RS-----------EFVFRFRVSSRFL 329  Encephalitozo...
EEQ82507      143 --------------------------niYs------------nI-----------------------DYTNMMDFTKKYL 161 
A0DPN6        351 ---------------------------------------------wMNsYFS--KKkq-------kiLISKKRQQLLPIF 376  Paramecium te...
O77448        433 ---------------------------wF--------------VDLKNqKFT--QKr---------kYISDKRKILGDLI 460  Tetrahymena t...
XP_001617069  816 lggretqlvtpapstplpthtpyeeektWklkrrrkqvrffdpEKDTPlFEI--LRrkylkkkkkinIALLKRHFLNRLI 893 
Q4MZJ7        377 --------------------------------------------------------------yhsmgQTRTILDYLCRII 394  Theileria parva
5C9H_A        222 -------------------------------------------VDLKNqKFTqkRK-----------YISDKRKILGDLI 247  Tetrahymena t...

4O26_A        198 TWLLDGFVVGLVRACFYATESVGQKNAIRFYRQEVWSKLQDLAFRRH 244  Japanese medaka
XP_002428028  415 KFIIFHYLFVIIKNNFYVTETGTSGYGLRFYNKKIMMKKSNEYLNKL 461 
XP_007604494  319 LFLFNSVFLKIVGYFFYSTTTSSTKLKIYYFTRISWNGRTDKFIREY 365 
Q8SQQ0        330 VYITEKLIIPIISKYFYCTETSFSKFKVHYFPRSIWRHFSSIHIDRF 376  Encephalitozoon cuniculi
EEQ82507      162 VFLFSDFYIPFINKFVYCTESCQTKYKCYYYVRHRWYKFSETCINAH 208 
A0DPN6        377 RFLFQLIIIPFLRHNFYITERMKDDWKLFYYRKEIWTLVLKLSLNQL 423  Paramecium tetraurelia
O77448        461 VFIINKIVIPVLRYNFYITEKHKEGSQIFYYRKPIWKLVSKLTIVKL 507  Tetrahymena thermophila SB210
XP_001617069  894 YFLFNYLIMPVIRKYFFLTKSEHTIYRTIFFDRKLWSYFTKISNFCL 940 
Q4MZJ7        395 FFVLQYLIVPALGRFMYITESGFSMYRIHYIRNEDWSKMVNRARNDY 441  Theileria parva
5C9H_A        248 VFIINKIVIPVLRYNFYITEKHKEGSQIFYYRKPIWKLVSKLTIVKL 294  Tetrahymena thermophila
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