4O26


Conserved Protein Domain Family
Telomerase_RBD

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pfam12009: Telomerase_RBD 
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Telomerase ribonucleoprotein complex - RNA binding domain
Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.
Statistics
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PSSM-Id: 403284
View PSSM: pfam12009
Aligned: 119 rows
Threshold Bit Score: 68.6744
Threshold Setting Gi: 429962320
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4O26_A       112 RVYLFVRECLTAVVPEELWGSDHNRLQFFSRVRGFLKSGKFERISVAE-LMWKIKVMDCd-wLKlRrTAGRFPPSELAYR 189 Japanese medaka
XP_001645197 272 DVNRFLIVILEKLLPKDCLGSSKNKSYLFSKISKLINLPMYSNMSFIE-IVEGLKTNDFk-iFT---SGKKLSLPEFNKL 346 Vanderwaltozyma...
CCE65283     268 NVNKFLTIILEKLLPIELLGSKKNKSIIFKNASRLLRQSITSNIPFNN-IIEKISTTHFs-wLQ---GTKKNNLQENLIS 342 Tetrapisispora ...
CAR29528     268 QVNRFIIVLVEKLVPIQMFGSKRNKSKVFHFISILLRLPLGGNIPLAE-IMTSLRINDFt-wLQ-------MNRSDTVKT 338 Zygosaccharomyc...
CDF87506     268 lVNKFVIIILQKLIPSEMFGSKRNKSKIFYYLSQLLRLPLKGTIPFSE-LKNSQRIEDFr-wIR---LVANCNESSLQNN 342 Zygosaccharomyc...
CCE91902     265 QVIRFLIVILQKLIPPELFGSKRNKAVIFKYVSSMLMLPVKGSLDIAE-IGNSLRLKDFs-wLI-Q-PNTQFVKHQYERT 340 Torulaspora del...
XP_003678419 272 QVIRFIIVILEKLIPIELFGSKRNKGKIFSKIATLLKLPLNGTIPFGK-ITSKLKIKEFq-wLH-T-PDSHFNKNSFQLS 347 Naumovozyma cas...
CCD27067     300 EITRFLIIILEKLIPSELLGSKRNKSKLFKMVPMILSFPGNTTIEFGRyALKNFKVKDLaisLL---KRSTITRDYFEVL 376 Naumovozyma dai...
XP_003955231 263 NVLKMVILVLEKLIPQEAYGSKRNKSVIFSKIPLLLSLPLNGSLPAET-IFENVRSRNLy-wLT-G-KQHDFSLKTHLRT 338 Kazachstania af...
XP_003644481 261 SVTRLITLFVDKIIPLELFGSRKNKSLILKRTSELLRLKINCQIPFEY-LIKGLRVTDVs-wLG-L-TSKGVPVCEFKRR 336 Eremothecium cy...
4O26_A       190 TRILSQFLTWLLDGFVVGLVRACFYATE-SVgqKNAIRFYRQEVWSKLQD 238 Japanese medaka
XP_001645197 347 KLIIHQFTSWIFRFLVPNIISTFFYCTNvSS--GIEIIFFRHDVWNKISM 394 Vanderwaltozyma polyspora DSM 70294
CCE65283     343 QLIIDSLVAWIFQFLIPRIVSSFFYCTNvSS--TIDILYFRHDIWNVLSF 390 Tetrapisispora phaffii CBS 4417
CAR29528     339 EDLVAHFIFWFFQRFVVKIIATFFYTTEvSS--NVEILFFRHDVWESIST 386 Zygosaccharomyces rouxii
CDF87506     343 QRLVACFISWIFKLIIPRIVTTFFYATEvSS--SVLVLFFRHDAWSKISA 390 Zygosaccharomyces bailii CLIB 213
CCE91902     341 TFLMQSFISWLFKSLIPNIISTFFYCTEiSS--YVSISYFRHDVWNGMSL 388 Torulaspora delbrueckii
XP_003678419 348 TEIMRCIIFWLFQSLIPKILSCFFYCTEiSS--TIDVIFFRQDSWIRIST 395 Naumovozyma castellii CBS 4309
CCD27067     377 TQVQHCFVLWTLTNLIPKILSTFFYCTEiSS--TTNVIYFRHDVWNELTA 424 Naumovozyma dairenensis CBS 421
XP_003955231 339 CMMFKQFLLWLFRNLIPRIIIRFFYCTEvSS--SLNIIYFTHDQWKKLTR 386 Kazachstania africana CBS 2517
XP_003644481 337 RRLFELFLDWLFRKFIPKLIHGIFYATEiSS--QTAVIYFRQDTWNEISA 384 Eremothecium cymbalariae DBVPG#7215
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