Conserved Protein Domain Family
EcoR124_C

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pfam12008: EcoR124_C 
Type I restriction and modification enzyme - subunit R C terminal
This enzyme has been characterised and shown to belong to a new family of the type I class of restriction and modification enzymes. This family is involved in bacterial defence by making double strand breaks in specific double stranded DNA sequences, e.g. that of invading bacteriophages. EcoR124 is made up of three subunits, HsdR, HsdS and HsdM. The R subunit has ATPase and restriction endonuclease activity. This domain is the C terminal of the R subunit.
Statistics
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PSSM-Id: 492296
Aligned: 111 rows
Threshold Bit Score: 85.0272
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8G3H5        768 LFVQKLPANVKSMDTRYREILDVFSDn--GesdlmQlpESVEARRKFAKEFVELNRYLEAAKVQG-FDWStpeykvdstd 844  Bifidobacteri...
WP_012360511  758 LFVDHLGDHLKSTNECFATIEALFTDpktGqpdfsQlpDVEADQGEFAKTFNRMYRELQAAQVQG-FTWDkdtyyfda-- 834  Corynebacteri...
WP_012938521  753 LFADHLPQNLQHMNERFQDMAQVFREa--GvpdmeRlpEDNTVRGKFAKLFREFSTYLQAAQIQG-FTWDtqeysitdld 829  Acidaminococc...
CCX64543      753 LFADHLPENIRHMNVTFEEMKYLFVNa--GqedmlQlpEDKTVCARFAKLFREYSTCYQAAQIQG-FVWTktdyvvpvse 829 
WP_013236478  753 LFADRLPINLERMNACFVEICAIFSAa--GitdfsKlpDDLAARAAFAKQFNRFSAILEAARIQG-FTWEksvyefgd-- 827  Herbaspirillu...
Q2KZC4        754 LFADQLPRNLERLNDCFTEISAIFSVs--GitdfaKlpDDLAARAVFAKQFNLFSAILEAAKIQG-FTWDqsvyefdt-- 828  Bordetella av...
2_pfamImport    1 LFVEKLPYNLKKLNVIYMDISEVFKSs--GvsdftKlpNDHAEKAKFAQLFKDFNHHLDAAKLQG-FNWEqdiytfndee 77  
WP_008522444  748 LFADRLNQNLEHMNSIFTQIKNLFESs--GianfeRlpEETAERKKFANLFKLFNHYLEAAKVQG-FQWNvlscgftdpd 824  Jonquetella a...
1_pfamImport    1 LFVEKLNRNLELLNTIYQDISDLFHQa--GiedfsHlpAEPEECKKFARLFRDLNARMEAAKIQG-FRWDkriyqfa--- 74  
P75431         75 MVMREFEEVFEKFKDWTEKIKQKYPNpd------eIlnLEKEEKWDFSDLFGEFLGDYRTVKSYHeFDKDn--------- 139  Mycoplasmoide...
Q8G3H5        845 tddanedndehdesevvrpQIDERTYLILAQRYKELF-------YGNSSCGGDsDDgvknnpeA---P------YeldgY 908  Bifidobacteri...
WP_012360511  835 ------------plepivvELTEDTYTTLVTRYKELG-------KAGDDSEQLpED-------A---P------FdidvH 879  Corynebacteri...
WP_012938521  830 ---------tgektgtisvIPTREQYKILLERYKELRne---psGGGGGVDPT---------------------FaidpY 876  Acidaminococc...
CCX64543      830 dns---eedepektellhvLPTRTEHDILQQRYKELAk------EPGLGSGYE----------V---P------FeidpY 881 
WP_013236478  828 -----------dakmqvtlTISHHQYLTLLQRYKELG-------GGSVGSGES----------I---P------FdidsH 870  Herbaspirillu...
Q2KZC4        829 -----------epkqsivvVITKLQYLTLLQRYKELG-------AGGGGAGET----------I---P------FdidsH 871  Bordetella av...
2_pfamImport   78 ----------tglnetiklDFGSNDFMALVQRYKELSng---ndDENGNGGSDgDD-------V---P------FdlvgY 128 
WP_008522444  825 ----------tgedrwvdvLIDERTYMVLVIRYKELFs------GGGDVENGE--D-------L---P------YeldgH 870  Jonquetella a...
1_pfamImport   75 -------------dstmevALDEHTFNVLSVRYNELFg------GGGGESDGHvPD-------V---P------YdipgF 119 
P75431        140 ------------------pYLPSDEFNKYFAAFSQIQeeirkekAEKKALEVQeED-------LsneVrkepqiF----S 190  Mycoplasmoide...
Q8G3H5        909 LTEINTGLIDTDYMNANFNKWLKALk---ENSPELAEMSAQLHRsfAALSRDEQRLAELFLHDVerg------dvEVEAG 979  Bifidobacteri...
WP_012360511  880 ITHIDTDRIDAEYLNSKFDKYLKALqd-gVPQDVLDDLLEELHDsfARLSKDDQRYANRWLHDLqag------dvTLQPG 952  Corynebacteri...
WP_012938521  877 LTELSTGLIDSQYLNSRFEKYRKILtqpdVDPAEKETTLEQLHKafASLSQEEQKYANLFLHDVeag------dvRMEPD 950  Acidaminococc...
CCX64543      882 LTDQNTGTIDYDYMNSRFDKWRKQLdqqdISREELDATLEELHKsfAFLSQEDQKHANRFLHDVqtg------diHLEKG 955 
WP_013236478  871 ITEIDTGKIDADYMNSRFAKFLKVLh--gGDEQAKEATLAELHRsfTSLSQEDQRIAEIFLHDIqrg------dvQIDPN 942  Herbaspirillu...
Q2KZC4        872 ITEIDTGKIDADYMNSRFAKYLKELq--sGDEPSKEVTLAELHRsfTSLSQEDQKLAEIFLHDIqrg------dvQIDPA 943  Bordetella av...
2_pfamImport  129 ITEIDTGRIDAAYMNSRFEKYLKNLhqadITEEQLQASLDELHKsfATLTQDEQKYAEIFLHDVqrg------evVVEDG 202 
WP_008522444  871 LTTIDTATINTDYMNSRFTKYLKLFhqkeASADLLKQAEEELHKtfAELSQEEQKFAGIFLRDIqrg------dvVPEDG 944  Jonquetella a...
1_pfamImport  120 PIPISTGAIDNDYMNSRFEKFRKLLg--nATEEELQQTEQELHKsfAFLSQEEQKYADIFLHDIkrg------dvVPVEG 191 
P75431        191 WEYGEGIQANLDYIFHLIKDLYNCDne-qDRQKVLDKIKTAIRT--NPEIQVNEDILNEFIEDLgksfekekleevwkte 267  Mycoplasmoide...
Q8G3H5        980 ITLRDYITRYAAREKNEQVDKLVDRLGVNrsvveEFlAKRIDEANINEFGRFDALRSSLDVQRakaffeqHDHKALPVF- 1058 Bifidobacteri...
WP_012360511  953 KTVHDYINEYRITERDRQLVRLHERLGLDmvqlhRIlDIRVTATTINEYGRFDDLKESVDLDLaaayfaeATGAPVSKF- 1031 Corynebacteri...
WP_012938521  951 CTFMDYIHQYANAERKRQVGKVTKYFGIPeevvcQMlDAHVNEQNYNAYGRFDDVKKYIVKEDaatyitaLEGKKVPPF- 1029 Acidaminococc...
CCX64543      956 KTIQDYISEYAVSEKKEQVHRLSVYLGCVeelvySMlDAHVTRENINEYGRFDALKNSVVKEKareyftaIDGKPLPMF- 1034
WP_013236478  943 RTFRDYLADYQAQAKNKEIEAIVEGLGIDaskllALmNAKTTDVNLNEFGRFDALLATVDKQKakayfeaQEGKSIPAF- 1021 Herbaspirillu...
Q2KZC4        944 RTFRDYLTDYKTAAKDKEVAAIVSALGVHaakliALmSTHLTEANLNEYGRFDDLRGTVDQEKakayfdgLEGVSLPIF- 1022 Bordetella av...
2_pfamImport  203 KTLRDYITEYQYKAKNDQIHSFAVAFGLDedllkNMmQLNLTEANIDEFGRFDKLKQSVNKAAakaflekIEGKVIIPP- 281 
WP_008522444  945 KTLRDYITEYMTKAKDAQIHRFAALFGLDegklrDLmAQKVTEDNINKYGRFAALKKTVDRAKateyfeaLTGEKIIPL- 1023 Jonquetella a...
1_pfamImport  192 KTFRDYVTEYMAKAQDDRIHRFAAVFGLDetllrGMmSHRVTEGNINDFGRFDALKATADKKKakayfetGSHTPLPPP- 270 
P75431        268 GKLRECLKDFCKKKEESNKKKIINDFLVKgvflvEW-VADKQLNTAKKKGEYSPSWSDTEKLIwkekst--nlptmtEKd 344  Mycoplasmoide...
Q8G3H5       1059 --------KVRMRATNMLKRF 1071 Bifidobacterium longum
WP_012360511 1032 --------KVRAMLDKLLRTy 1044 Corynebacterium urealyticum
WP_012938521 1030 --------RVNNMAESILKEF 1042 Acidaminococcus fermentans
CCX64543     1035 --------RVHNRVDAFLTDF 1047
WP_013236478 1022 --------KVNIKTENLLRMF 1034 Herbaspirillum seropedicae
Q2KZC4       1023 --------KVKIKAAKLLSDf 1035 Bordetella avium 197N
2_pfamImport  282 --------KVNMKVDKILRKF 294 
WP_008522444 1024 --------KISTKIDVTLRKF 1036 Jonquetella anthropi
1_pfamImport  271 --------KVAMKLDKILRDF 283 
P75431        345 edgnfkwrKLITDISEAFKNH 365  Mycoplasmoides pneumoniae M129
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