Conserved Protein Domain Family
DAB2P_C

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pfam12004: DAB2P_C (This model is not part of the current CDD release)
Disabled homolog 2-interacting protein, C-terminal domain
This domain is found at the C terminus of some GTPase-activating proteins (also known as GAP) found in animals, including Disabled homolog 2-interacting protein (DAB2P). This region is found associated with pfam00616 and pfam00168, and includes a coiled-coil domain that forms a parallel trimer in solution with one helical strand from each monomer.
Statistics
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PSSM-Id: 520016
Aligned: 19 rows
Threshold Bit Score: 501.238
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
F6SEU4        718 LNDISTALRNPn-IQRQPSRQSERTRSQpmVLRGPSAEMQgYMMRDLNSsIDlqsfmarglnssMDMARLPSPTKEkppp 796  house mouse
8_pfamImport    1 LRDVNVALTNPagAPVA--SPTERVGSPslPGCSVSTGLQ-KLVMDTEL------------------------------- 46  
Q9UJF2        609 LADITKSLTNPtpIQQQLRRFTEHNSSPnvSG-SLSSGLQ-KIFEDPTD---------------SDLHKLKSPSQD---- 667  human
XP_008116004  745 LTDIAKATTNPtpIQQQLRRLADHNSSPn---vSLSSGLQ-KIFEDPTD---------------SEI-KCKSPPEE---- 800 
XP_014341095  748 LGDITKSLTNPtpIQQQLRRFMDPSASPnvSG-SVSSGLQ-RIFEDPAD---------------SDVQKLKSPPQE---- 806 
XP_069050154  749 LGDITKSLSNPtpIQQQLRRFQDHNSSQniSG-SVSSGLQ-RIFEDPSD---------------SDLHNMRGPTQE---- 807 
6_pfamImport    1 LGDITRCLAAPtpVQQQLRRFQDHSSAHniSG-SLSSGLQ-RIFEDPSD---------------SEVRSLQTPV------ 57  
4_pfamImport    1 LGDISRCLATPkpIQQQ-QCVQDNSCAHsiST-SLSSGLQ-RIFEDPVD-SH------------SEVLSVQSSV------ 58  
2_pfamImport    1 LGEITQSLAAPtpLPQQLQRFQHHSSAHniTG-SMSSGIQ-RMFEGAAD------------------RYLHSQA------ 54  
XP_015146000  735 LADITKSMTNPtpIQQQLRRFTEHSSSPnvSG-SLSSGLQ-KIFEDPTD---------------GDLHKLKSPTQE---- 793  chicken
F6SEU4        797 pppggGKDLFYVSRPPLA-RSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQgdgpGGRLNSSSVSNlAAVGDLLHSSQA 875  house mouse
8_pfamImport   47 ------------TGNSVI-QPSPARSSSYSEANEPDVQLPNGSKSLSMVDLQ----DSRSLEGPCTS--------SSDPS 101 
Q9UJF2        668 -----NTDSYFRGKTLLLvQQASSQSMTYSEKDERESSLPNG-RSVSLMDLQ----DTHAAQVEHAS-VMLDVPIRL--T 734  human
XP_008116004  801 -----N-EGYFKGN-LLLiQQSSSRSVTYSDKDDETN-LPNV-RSISLMDLQ----DPNAAQCDPSS-VMQDAPVRL--S 864 
XP_014341095  807 -----NTDVYFWSKPPILsQQASTQSMSYSDKDERENVLPNG-RSVSLMDLQ----DSQVAHGDRVP-VLHDMPVRL--V 873 
XP_069050154  808 -----HADGHVRSKHPLLgQQSSTQSMSFSDKEERENPLPNG-RSISLMDLQ----DPHIVHSERLP--IHDVPARL--T 873 
6_pfamImport   58 -----------RGQRPLLaQQHHSNHTSFSDQEERDTLLPNG-RSISLVDLQ----DAQSLHGNTGPpPHHEAPPRLSRV 121 
4_pfamImport   59 ------SDVSGRSSQRQIpEKPGKPSLSNTPAGSAGTGMPNG-RSRSLVDLQ----DPKN-QGPMGP-PLPEAPACL-RR 124 
2_pfamImport   55 ---------HTVYRPLPI-PNG-------GQGQQRDSLLPSG-RSVSLVDLQ----EVRSLQDAPQPlPHHEGP-CLSRS 111 
XP_015146000  794 -----NIDGYFRGKTLLLvQQASTQSMTYSDKDERESILPNG-RSISLMDLQ----DPHTAHSDHAS-MMHDVPLRL--A 860  chicken
F6SEU4        876 SLTaalglr------------papagRLSQGSGSSItAAGMRLSQMGVTTdGV-----PAQQLRIPLSFQNPLFHMAA-- 936  house mouse
8_pfamImport  102 NDGqgng---------------awsaRTLKGNMVTG-PTLRKTAQTPTTP-STetapgRP-QLLAPLSFQNPVYQMAA-- 161 
Q9UJF2        735 GSQlsitqv-----------asikqlRETQSTPQSA-PQVRRPLHPALNQ----------PGGLQPLSFQNPVYHLNN-- 790  human
XP_008116004  865 GSQlsvtqv--------------anikqlQNTPQSA-PQVRRPLHAAVNQ----------QGSLQALSFRNPVYHLNN-- 917 
XP_014341095  874 GSQisigqt-----------asvkqlRETQSTPQSA-PQIRRPLHPALSQ----------QVSLQPLSFQNPVYQLSN-- 929 
XP_069050154  874 GSQisihphphsqhqfypqlasktslREAQVLPQSA-PQIRRPLHPALSQ----------QGSLQPLSFQNPVYHLSN-- 940 
6_pfamImport  122 GSQasvgha-----------vapakvPPRDGQPQSA-PQVRRPLHASVSQ----------QRSLQPLSFQNPVYHLSNpa 179 
4_pfamImport  125 ASKasvpppltycqs------alivtepvvqpPHSA-PQVRR-LHATVAQ----------QHSLQPLSFQNPVYHLSN-- 184 
2_pfamImport  112 GSRasisaapt--------paskaphKDLQ--PQSA-PQVRR-LQPPLTQ----------QRSLQPLSFQNPVYHLINpa 169 
XP_015146000  861 GSQlsitqv-----------anikqlWETQSTPQSA-PQVRRPLHPALNQ----------QGSLQPLSFQNPVYHLNN-- 916  chicken
F6SEU4        937 -DGPGPPAGHGgssghgppsshhhhhhhhhhrggEPPGD---TFAPFHGYSKSEDLSSGVPkpPAaSILHSHSYSDEFGP 1012 house mouse
8_pfamImport  162 -GLPVSPRGGGa---------------------aDSGSE---CHSSISSQGNAEDP-APPV--TKpTFITQAST---FVR 210 
Q9UJF2        791 ---PIPAMPKAs---------------------iDSSLEnlsTASS-RSQSNSEDF--------KlSGPSNSSM-EDFTK 836  human
XP_008116004  918 ---PPQPMPKVs---------------------mDSSLEnlsIPSS-RSQ-NSEDL--------KlSGPSNSSM-EDFAK 962 
XP_014341095  930 ---PPSSGPKPs---------------------mDSSSEnlsTTSS-RSRSNSEEF--------KlSGPSNSSM-EDFTK 975 
XP_069050154  941 ---PPHPACGP-----------------------DSSSEnlsTESS-RSRSNSEDFAATG----KlSGPSNSSM-EDFSR 988 
6_pfamImport  180 hSMSTRSAHSLr---------------------qDSSSEnlsTESSHNSHSNSDDFGSQVG--GKgRAPSNSSLDEVGSR 236 
4_pfamImport  185 ------PAHCLs---------------------tHSSSEnlsTESSHASHSTSDGCSLQA---------GSSSARELDGK 228 
2_pfamImport  170 nSLSTRSAHSLr---------------------rDSSSEnlsTESSHNSHSNSDDFGSQEA--GKaCAASNSSLDEGGSR 226 
XP_015146000  917 ---PPAPMPKAs---------------------vDSSLEnlsTASS-QSRSNSEDF--------KlSGPSNSSM-EDFTK 962  chicken
F6SEU4       1013 SGT------DFTRRQLSL---QdSLQH-----MLSPPQITIGP--Q-RPAPSgpgggsgggsgggqpPP-LQRGKSQQLT 1074 house mouse
8_pfamImport  211 RSG------EFTRRQLSL---T-ENQHq----SNVPRQNSAGP--Q-RRIDQp-------------pPPtVTRGRTPPSM 260 
Q9UJF2        837 RSTqse----dfsRRHTV---Pdrh-----ipLALPRQNSTGq-aQiRKVDQggl---------------gaRAKAPPSL 888  human
XP_008116004  963 RSThse----dfsRQGAI---Ldkh-----mpIALPRQNSTGq-aQiRKTGlg------------------aRVKTPQSL 1011
XP_014341095  976 RSTqse----dfsRRHTI---Pdrn-----vpIALQQQSRAGh-aQiRRTDQagl---------------scRGKAPNSM 1027
XP_069050154  989 RSTqsedcaP---RRHAP---P--DRLaaaqpPALPRQNSTGt-aQiVRVEQqsrs-------------gsgGARTPRSL 1046
6_pfamImport  237 RSTqs--eeCSTPRRHAL---Q-DLPPgtataVAIPRQSTTAGtaHiIKVEQqs----------------kGGGQGRHGL 294 
4_pfamImport  229 RSDrteessCT------------PGPAgtptaVAVLCQSTAAGtaHiVRVEQqsr--------------aggGARTPRSP 282 
2_pfamImport  227 RSTqs--eeYFSPRRLVR---P-NLAQsaataVAIPRQSTTTGtaHiVKVEQqsr--------------vggGARTPHSL 286 
XP_015146000  963 RST------Q-SEDFSRRhtvP-DKHVp----IALPRQNSSSQa-QiRKMDQagl---------------gaRAKAPQSL 1014 chicken
F6SEU4       1075 VSAAQKPRPSSGNlLQSPEPSYGp------aRPRQQSLSKegsiggsggsgggggGGLKPSITK---------QHSQT-- 1137 house mouse
8_pfamImport  261 LNTAPYPRPSSGS-MMSSSPDWPss----saRLRQQSSSS---------------KGDSPETKQrt-----lhKQAPSpv 315 
Q9UJF2        889 PHSASLRSTGSMSvVSAALVAEPvqn---gsRSRQQSSSSr--------------ESPVPKVRAiqr---qqtQQVQSpv 948  human
XP_008116004 1012 PHSASLRSTGSMSvASATMAAEPvqn---gnRSRQQSSSSr--------------ESPVPKVRAiq-----qqQTQQSpv 1069
XP_014341095 1028 VHSTSLRSTGSITgTPVVVPSDTlpn---gsRSRQQSSSSr--------------ESPVPKVRAvhrqmqpsqQQVQSpv 1090
XP_069050154 1047 PHSASLRSTSSAA--GGPYKQEPsph--ngsRSRQ-STSSr--------------ESPVPRARMvhkq--qppQQVQSpv 1105
6_pfamImport  295 LHTAPHCAAAAQM------PQVRq------kSGKSQTLSV---------------SGVFLMMSLv-------cVQVASpv 340 
4_pfamImport  283 SQSASLHSSESSVnTEVMTPG----------HTHQQRHSH---------------VGENPALRSask----ppQQVGSpv 333 
2_pfamImport  287 PVGSSLCSSSSAN--TEPTPTAGp-------SNLQQSSVE---------------------------------NVVTSpv 324 
XP_015146000 1015 PHSASLRSTGSMS---AVSGAVVtepvqngsRSRQQSSSSr--------------ESPVPKVRAiqr---qqtQQVQSpv 1074 chicken
F6SEU4       1138 ---PSTLNptmpaseRTVAWVSNMPHLSADIESAHIE---------REEYKLKEysksmdesrldrvkEYEEEIHSLKER 1205 house mouse
8_pfamImport  316 --nPGALD-------RTAAWLLNMNVQYLEQEGIDPDsrhredlpnKDELSQTE--------------K---EISMLQER 369 
Q9UJF2        949 --dSATMSpv----eRTAAWVLN-NGQYEEDVEETEQn--------LDEAKHAE--------------KYEQEITKLKER 999  human
XP_008116004 1070 --dSATMSpv----eRTAAWVLN-NGQYEEEEEDGEQn--------QDGTKHAE--------------KYEQEITKLKDR 1120
XP_014341095 1091 --eSATMSpv----eRTAAWVLN-NGQFEDEEENEQA---------RDESKHAE--------------KYEQEITKLKER 1140
XP_069050154 1106 --eSITMSpv----eRTAAWVLN-NGQYEDEDELEQS---------REDSKHAE--------------KYELEISKLKER 1155
6_pfamImport  341 eavAVAMSpv----eRTAAWVLN-NGQYEEKEEEGGEr-------sRDEGRNTE--------------KYELEISRLKER 394 
4_pfamImport  334 evvEAVMSpv----eRTAAWVLN-NSQYEDEES-------------REEGRNPE--------------KYESEIVRLKEC 381 
2_pfamImport  325 --eAAVMSpv----eRTAAWVLN-NGQYEEEGGRGGPi--------REEGKKTE--------------KYELEISRLKEC 375 
XP_015146000 1075 --dSATMSpv----eRTAAWVLN-NGQYEEVEEDTEQn--------PDEAKHAE--------------KYEQEIAKLKER 1125 chicken
F6SEU4       1206 LHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQVEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLpEPK 1285 house mouse
8_pfamImport  370 LRLSAKKLEEYEVRLQGQDDQTQKMLLEYQARLEDTEERLRRQQEDKEMQMKSIITRLMSVEEELKKDHADMQAIV-DSK 448 
Q9UJF2       1000 LRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVI-DAK 1078 human
XP_008116004 1121 LRVSNRRLEEYEQRLLVQEQQMQKLLMEYKTRLEDSEERLRKQQEEKDSQMKVIISRLMAVEEELRNDHAEMEAVI-EIK 1199
XP_014341095 1141 LKVSSRRLEEYERRLLAQEQQMQKLLMEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVI-DAK 1219
XP_069050154 1156 LRVSSRRLEEYERRLLAQEQQMQKLLLEYKTRLEDSEERLRRQQEEKDSQMKSIICRLMAVEEELKRDHAEMQAVI-DAK 1234
6_pfamImport  395 LRVSGRRLEEYERRLLAQEQQMQKLLHEYKNRLEDSEERLRRQQEEKDTQMKSIICRLMAVEEELRRDHAEMQAVI-EAK 473 
4_pfamImport  382 LRSSGRRLHQYERRLLAQEQQMQKLLQEYQQRLEDSQERLRRQQEEKDGQMKSIICRLMAVEEELNRDHAEMQLVI-EAK 460 
2_pfamImport  376 LRASGRRLEEYERRLLAQEQQMKKLMLDYKSRLEDSEERLRRQQEEKDSQMKSIICRLMAVEEELKRDHAEMQAVI-EAK 454 
XP_015146000 1126 LKVSSRRLEEYERRLLVQEQQMQKLLMEYKSRLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVI-DAK 1204 chicken
F6SEU4       1286 KRLLDAQERQLPPLGPTNPRVTLAPPWNGLAP 1317 house mouse
8_pfamImport  449 QKIIEAQEKRIASLDAANARLMSALSQLKERY 480 
Q9UJF2       1079 QKIIDAQEKRIVSLDSANTRLMSALTQVKERY 1110 human
XP_008116004 1200 QRIIDAQERRIFSLDRSNTRLTKALAQVKERY 1231
XP_014341095 1220 QKIIDAQEKRIVSLDAANSRLMSALTQFSRRG 1251
XP_069050154 1235 QKIIDAQEKRISSLDAANSRLMSALTQVKERY 1266
6_pfamImport  474 QKIIDAQEKRIGSLDAANSRLMAALTQVKERY 505 
4_pfamImport  461 QKIIDAQERRIGSLDAANSRLMTALTQVKERY 492 
2_pfamImport  455 QKIIDAQEKRIGSLDVANSQLMAALTQVKERY 486 
XP_015146000 1205 QKIIDAQEKRIVSLDSANTRLMSALTQVKERY 1236 chicken
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