3I4X,3O24,7XVJ,5KCG


Conserved Protein Domain Family
Trp_DMAT

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pfam11991: Trp_DMAT (This model is not part of the current CDD release)
Tryptophan dimethylallyltransferase
This family of proteins represents tryptophan dimethylallyltransferase (EC:2.5.1.34), which catalyzes the first step of ergot alkaloid biosynthesis. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 390 to 465 amino acids in length.
Statistics
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PSSM-Id: 520008
Aligned: 97 rows
Threshold Bit Score: 169.796
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3I4X_A        31 DQKLWWHSTAPMFAKMLETAN-YTTPCQYQYLITYKECVIpSLG---CYPTNSaprwlSIL--TRYGTPFELSLNCSN-- 102 Aspergillus fum...
Q0C8K4        16 DTEFWSEHIRSVIGPLMKATGsYSGTAQEANLRFLDNYIApALG---PHPTVAhp--tYVApcTIVGTLFNPSISLSAkg 90  Aspergillus ter...
M2Y2F4        10 HHKFWANHLLPQFRRYIAEIGaYTSKQQDEHVKFFDS-LLpHLGprlPHPHTK-----AVL--TVANMPLGFSVNLSDar 81  Dothistroma sep...
EFQ90212      87 avNVWANYLVPRFHKYLAETGsYTVEQQEAHALCLSAAVV-ALGprhPHPHVK-----SVM--TPNGCPIELSLNLSEdr 158
XP_007813282  12 DLRYWMRHSVPPLLALLRAAGsYSDADQGKHIQFLCDYVLpNFG---PRPTEAsp-srSRF--TQSGFPMDLSLNLNAg- 84 
XP_007813283  19 DIKYWSDNFIPPLKSLLQATEsYSRSEEEAQLRILKEDVLpNLG---PRPSKAvg--pSHL--TQSGSPLQLSLNASSs- 90 
XP_003715802  11 DQQYWWQFVEPSLSSMLEYAGqYTPEEQDSHLEWYATQVTpIFG---IQPSEEtp-dpNPF--THDSSPCHISINWCSkg 84 
XP_003347762  56 NHNYWWTACAPSLTSILRHSNsYTPTQQSLHLTWFRNNVIpNLG---PRPSSSyr-lrSPL--NYEGSPYRPTWNFCSap 129
XP_018151734  25 DVDFWSSYLVPRFHAYLSEAGsYTPEQQAAHLSCVRAAAV-ALGpkhPHPHVK-----SAL--TKNGSPIELSFNLSEdr 96 
XP_011395036  55 NHHYWWTACAPSLTSILRHSHsYTPSQQSLHISWFRNNVIpNLG---PRPSSSyr-lrSPL--NYEGSPYRATWNFCSap 128 Neurospora cras...
3I4X_A       103 -----------SIVRYTFEPinq-htgT-DKDPFNTHAI----WESLQHLLPLe---KSIDLE----WFRHFKHDL-T-- 155 Aspergillus fum...
Q0C8K4        91 ----------kPTVRFDYDLplpldraS-SDDPWGEGKA----RTLFRRLAAa----LGADTQ----WLEYFMARL-F-- 144 Aspergillus ter...
M2Y2F4        82 ----------kPIARMEIEPldd-tsgS-AEDLFAANCIpacfTTLVKGMt------TRVDTR----WAHQLRQAF---- 135 Dothistroma sep...
EFQ90212     159 ----------pPTARFYLEPlgs-rtgT-DEDPFGELWT----PSSFACLAAQv---PSADAR----WYQHLSQAFrL-- 213
XP_007813282  85 ----------kPKVRYCWEFlgp-ngpE-DNDMYAIGAL----RKCLESLATe----LGFSTQ----WADALLDALa--- 137
XP_007813283  91 -----------NCVRYCWEMlga-sggH-GRDPLAIQAA----QDIVASVSAk----FGFSTK----WSSALLSAFa--- 142
XP_003715802  85 ----------kPTVRsg---------mTrPHDVFNSQAF-------VDELQPAmetsDQPDRA----IFDGLAKSLfL-- 132
XP_003347762 130 pgssssspkvkGTLRFSFEPipa-tgtS-EEDPTNQEGY----RRLFPLLAGEchgvGGVETKadltWYNEVKEHMyLln 203
XP_018151734  97 ----------lPTARFYIEPlgp-etgT-ENDPFGESWA----ARGFSCLASQm---TSMDTS----WYEHLGQAFrL-- 151
XP_011395036 129 agsp-ssssvaGTLRFSFDPipa-tgsI-KKDPTNQEEY----KRLFPLLAREchgkGETKVV----FQSKIVSRGs--- 194 Neurospora cras...
3I4X_A       156 -------------LNSEESAFL----------Ahndrlv--ggtirtQNKLALDLKDGRFALKTYIY----PALKAVVTG 206 Aspergillus fum...
Q0C8K4       145 -------------LSPAETEALrs-------kIpadl-------vipSAMVGVAFDDAQPRLKAWVP----TMRRAILEG 193 Aspergillus ter...
M2Y2F4       136 -------------TPTSEESAIakprlrp------------giervslAYFGITFDGDNR--AMKYCtshwPKFLGTATA 188 Dothistroma sep...
EFQ90212     214 -------------QGEDEVSKA----------Ksqsrp----gvwlpTMFMGIDFVAANRLLKCSFC----PILKLLAMG 262
XP_007813282 138 -------------PTPEEATTTqqnirqwqasLlppgvepkpgarlpFAALAFGLDGPRTDTKFYIS----PQIKELGSA 200
XP_007813283 143 -------------VKPDEAQHIidmlpqwlqsFvpegveaaplkripFALTAFDLKGSNISMKLYVN----PKAKEIITG 205
XP_003715802 133 -------------KDPQEIAKVkavvpph------------lhtripnIGIAWDLVGAKRKLKLYHN----PQAKKLATS 183
XP_003347762 204 qeravlkerlvpgQLPPEHAAI-----------------------------AIACSREKRVLKPYFF----AGPTSLVTG 250
XP_018151734 152 -------------KGQVEVDTA----------Nsqsrp----gmwlpKVFLGVDFKGADRMLKCGFC----PLLKLSAMG 200
XP_011395036 195 -------------QLPPEHAAI-----------------------------AIGCVGEKRVLKPYFF----AGPKSMVTG 228 Neurospora cras...
3I4X_A       207 K------TIHELVFGSVRRLAV-REPrILPP-LNMLEEYIRSRg------------------------------SKSTAS 248 Aspergillus fum...
Q0C8K4       194 R------SSNEIAVEVLRGLSPlGSE-ITPA-IDMVEAWIA-A-------------------------------SPHDPR 233 Aspergillus ter...
M2Y2F4       189 Esnd-atSADAFLFSAIRRLKPgGEA-LAPS-LDAIQHYFQNEr-----------------------------hAKLPSP 236 Dothistroma sep...
EFQ90212     263 AdwnhlaDHNQFVLDAVRQLPGfGAN-AGAA-LDLLAQYLVEAsesgasvhntsvv-----nsgleegesgpkaKTPKPF 335
XP_007813282 201 K------SMNETIWNVARHL---EPP-ISQNaIRAVSEFLLER--------------------------------PGPPC 238
XP_007813283 206 T------PAADEVWKVLRNL---TPA-FKPEaIDMLEKFFTGL--------------------------------PEPSP 243
XP_003715802 184 R------TGNDIIVSSIRALANdGYN-YNEA-MDVLERYVTEL-------------------------------NPEKLE 224
XP_003347762 251 F------SPHQVLFSALRAIRTrREE-LKPA-IKLVESYVSSR--------------------------------ASTMT 290
XP_018151734 201 AkwdrlaDHNKFVLDVVRGLPGcGAN-MSAA-LGMLERYLVQDrehsagaqgqgdgvddgrkdassmcqacakaNRPKPF 278
XP_011395036 229 L------SPHQVLFSALRAIRTkAEE-LKPA-IDLVEDYVASR--------------------------------KAVMM 268 Neurospora cras...
3I4X_A       249 PRLVSCDLTSP-------A----KSRIKIYLLEQMVS-LEAMEDLWTLGGRRRDASTLEglslvRELW-DLIQLSPglks 315 Aspergillus fum...
Q0C8K4       234 LMLVGMDCGEP-------R----DSRLKIYLVTTKNS-WATVQDVMTLGGRLDDEPTRKqlallRKIWpYLINEPDntri 301 Aspergillus ter...
M2Y2F4       237 ILFVGLDCIDP-------S----RARIKMYGRTHSTA-FSNVRNIMTLGGRALTAETTEflarlRSIWhLLLNDPKakdd 304 Dothistroma sep...
EFQ90212     336 FNLVSVDCSDL-------Sn--gKGRVKLYARITSTS-FASIRDAVTLGGRLTDEVTVEglrhlESIWhLLLNDPAiend 405
XP_007813282 239 MDMLCVDLVKEqn----lH----RARFKIYVHTTSNS-FNTVRQCISLGGRRQDEATLKglevlRTIWhLLLQEKEevtd 309
XP_007813283 244 IELVGIDCVDDgh----lS----DARVKLYIHTRSNS-FKTVRKYVSLGGKLNDEETNKyleklQPIWhLLLQQPEgpvd 314
XP_003715802 225 LIIIGMDAAEPt-----lP----TTRIKPYGIVAEANsWETVKNIYTLGGQVLNQERKQgldilRSIW-DLMRCHRgqrl 294
XP_003347762 291 PSCFGIDAVSPfpssdqqGgaaaAARVKLYTLVPSNA-FSVMRDAMTMGGRLASPESLRgvallKWIYhLLRGDRSrvse 369
XP_018151734 279 FNLVSVDCADP-------Sn--gKGRVKLYTRTSCNA-FACIRDAVTLGGRLTDEDTLEglrrlRSVWhLLLNDPVsqhd 348
XP_011395036 269 PNCIGIDAVSPd----------qGARVKLYTLIPSNA-FCVMRDAITLGGRLTSPEAMRgvgilRGIYhLLRGDRSpind 337 Neurospora cras...
3I4X_A       316 ypapylpl--gvipderlplmA-NFTLh-qNDP--VPEPQVYFTT--FGMNDMAVADALTTFFERRG--WS-E 377 Aspergillus fumigatus
Q0C8K4       302 adenwckp-ermprvgffglmY-SLEIk-pGRP--TPEVKLYVPLfqYAESWAIAENNMETVLKLLD--ID-W 366 Aspergillus terreus NI...
M2Y2F4       305 edydrpp---ldpnslrtgllV-SFEVsalVST---PDIKVYVPFwqYHETDVQAINNLEQIFSLLG--WD-W 367 Dothistroma septosporu...
EFQ90212     406 adyarpp----dskssfpgidV-NWEV---SNQlpVPHAKVYIPVhiFHANDVEVHRNLSQVFRKLG--WNdW 468
XP_007813282 310 dnekpvn-----dpaelvmklffCIEFt-pGED--LPDVKLHVPIfnYLKSDRETIENLEKVFLKCGqeWAvn 374
XP_007813283 315 ddfekpin----dssmlcqklyfSFELq-pGRD--FPNVKTYLPTwnYVRTDEETIRNYQEIFQICGhpWGee 380
XP_003715802 295 addyhmp---kndssstrgvlTpSFEVk-pGQS--LPDVKVYVSQwqFAKTDREIAECTVEIFKRLG--WQ-K 358
XP_003347762 370 atyhvskpcryetrknsywmgFtSYEMq-pGRE--DPDVKVYLPLmqFFETEEAVVAALETVWRVLG--WGeE 437
XP_018151734 349 deysrtv----aveshrqgidI-NWEI---SDQlpAPQAKVYVPVsmFHENDLGANRNLSEAFRKLN--WLeW 411
XP_011395036 338 atenmskpcryesksnsywkgFtSYEMr-pGRE--EPEVKVYVPLmqIFETEQAVIEGLEEVWRGFG--WGeL 405 Neurospora crassa OR74A
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