1ZO1,3IZY


Conserved Protein Domain Family
IF-2
?
pfam11987: IF-2 (This model is not part of the current CDD release)
Translation-initiation factor 2
IF-2 is a translation initiator in each of the three main phylogenetic domains (Eukaryotes, Bacteria and Archaea). IF2 interacts with formylmethionine-tRNA, GTP, IF1, IF3 and both ribosomal subunits. Through these interactions, IF2 promotes the binding of the initiator tRNA to the A site in the smaller ribosomal subunit and catalyzes the hydrolyzis of GTP following initiation-complex formation.
Links
?
Statistics
?
PSSM-Id: 520006
Aligned: 425 rows
Threshold Bit Score: 64.4012
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
1ZO1_I        276 EVKLARQQkSKLENMFANMT-EgEV--H---EVNIVLKADVQGSVEAISDSLLKLST-D----EVKVKIIGSGVGG-ITE 343  Escherichia coli
ELQ74621      531 YGSEEDAKqQVMEDIKELT----NL--E---KVGIHLQASSLGSLEALIALVK---N-------ERIPVASVGIGKnLSR 591 
EPR79054      498 EEEAKKEVmQDLQNVISKV----KT--E---EIGVHLQSSTLGSLEALVEFVT---S-------SNIPIATVGVGK-LNK 557 
XP_002140628  639 IELLREQVmEDMGEVFRSV----DK--S---GNGVYVMASTLGSLEALLVYLK---S-------CNIPVVALNIGT-VHK 698 
NP_173540     820 MEEAKKNAmEDIESVMNRI----DK--S---GEGVYVQASTLGSLEALLEFLK---S-S----DVKIPVSGIGIGP-VHK 881 
Q553N4        761 DNEEEMNGtEDLg----------DIekK---TVRFFVKGDVTGTAEALSAMLFTLPqdP----EISIDIQRVGYGE-VTE 822  Dictyostelium...
XP_002678197  475 LTEGVEGEkAQEEKVEEEKK-------Y---ILPIILKTDVVGTIDAFSEIISSFPT-E----IAQIQIIKQTVGP-VST 538 
Q4UA29        400 IDKVRPKTnKNFQNEDSDRY-------K---YIPTIIRCDVKAIVEPIKMAIEKLRS-TgiskICKYKVLDADIDN-LTQ 467  Theileria ann...
XP_652306     622 DEEL-EEVkKEVQSEFEKF----QV--SvseKEGVFVQASSLGSLEALLKFLK-----D-----SKIPVSGVGLGP-IFK 683  Entamoeba his...
XP_002259650 1145 SPEDNPTEkINNEREIKNFQeK-DLrtV---YVSYFIKCDKQGTIDVLKNCLQKLQV-NdtlhRVRNKIVYSSIGD-ITA 1218 Plasmodium kn...

1ZO1_I        344 TDATL-------AAASNAILVGFNV-RA-----DASARKVIEAESLDLRYYSVIYNLIDEVK 392  Escherichia coli
ELQ74621      592 KDVLKmka-ikeKDAHVGIMLCFDT-KI-----DKEMTDLAESQHIKIFEAQIIYNLIDKYK 646 
EPR79054      558 KDIVRasi-maeKSIEYSPLLCFDI-KI-----DKEISEIAEKYNIKIFCEKIVYNLLDKYK 612 
XP_002140628  699 LDVRRasimherGHPEMAVILAFDI-KV-----EAEAELEAKKLGVKIMKANIIYHLCDMFT 754 
NP_173540     882 KDIMKagv-mleKKKEFATILAFDV-KI-----SAEARELADKMGVKIFCDDTIYCLFDKFK 936 
Q553N4        823 NDIKD-------ALFLKTPIVYFGS-KL-----NPKILDSCKKQGVKLIQSDVIYHVVNHVQ 871  Dictyostelium discoideum AX4
XP_002678197  539 ADIQLa------KVVEGTQIIAMNA-KV-----APNISIDAKSNNINIAQFKVIYHLIDYLK 588 
Q4UA29        468 DDVDL-------FDKP-GIVVAYNS-TI-----SSTMQNKLKKQEIKLISGEKIEDIVKTAE 515  Theileria annulata
XP_652306     684 KDVMKtli-mkeKNPDYAIIMAFDV-TV-----DKEARDYAAEEGILIFTANIIYHLFDQFT 738  Entamoeba histolytica HM-1:IMSS
XP_002259650 1219 SDITY-------AQSFDAIIIGFNVkLSksfpkNGKNITSGGKSNSRIIYVNVLYDLIEEVE 1273 Plasmodium knowlesi strain H
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap