4BKW


Conserved Protein Domain Family
SARA_C

?
pfam11979: SARA_C (This model is not part of the current CDD release)
Smad anchor for receptor activation-like, C-terminal
This domain is found at the C-terminal end of a group of animal zinc finger FYVE domain-containing proteins, including Smad anchor for receptor activation (SARA), which plays a significant role in TGF-mediated signalling. This domain is involved in the interaction with the TGF-beta receptor. This domain is found associated with pfam01363.
Statistics
?
PSSM-Id: 520002
Aligned: 25 rows
Threshold Bit Score: 391.623
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4BKW_A        154 LPTPPYLFGILIQKWETPWAKVFPIRLMLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLV 233  human
Q7QH71        415 APEAPYLIGILIHRWEVPWAKILPLRLMLRLGALYQYYPCPHVSERERESVYVEIAQTIVNLLADFRHFSYTIPSVRGMV 494  Anopheles gam...
XP_974100     648 KPQEPFLIGVLIHRWETSWAKLFPLRLILRLGAEYRYYPSPIISNRYRDSVFVEIGHTIINLLADFRNFSYTLPQIRGLS 727 
XP_002428675  389 LPPPPFLVGILIHKSEIPWARVFPLRLMLRLGAEFRYYPCPLVSVRFREPVYYEVGHTIIKLLADFQNLKYTIPSVRGLR 468 
2_pfamImport    1 LPSPPYLFALLVHQYETPWAKMFPIRLMLRLGAEYRYYPCMLVSIRNRPSLYTEIGQTVIKLLVDFRQYSYGLPTVKGCY 80  
XP_002114870 1624 IPKSPYLFGLLIHRNELVWARAFPLRLLVGLGNYYKEYPYPIWSYRDRQALFSEIGHTIMRLLIDFDSGQYTLERIPGLI 1703
EFX65324      217 LPTPPYLVAVLLQRWEIPWAKVFPLRLLLRLGAEFRYYPCPLFSVRKRKSVFGEVGHTIVNLLADMRNFSYSLPAVAGLV 296 
EDO36159      114 LPTVPYVVGVLIQRLEAPWAQLFPLRLMLRLGTEFRYYPCPLWSVRGRPSVYGEIGHTIMNLLTDFKNFQYSIPRVTGLV 193 
XP_011146277 1109 LPPAPFLVGLLIHRWETPWAKVFPLRLLLRLGAEYRYYPCPLVSVRFRDALYFEIGHTVMKVLADFRNFGYTLPGVKGLT 1188
XP_009013449 1378 LPPPPYLFAVYVHSNELMWAHAFPLRLVFRLGAEFRYYPCPLVSRMNRPAVYGEVGHTIMNLLVDFRNFQYTMNKIDDLV 1457
4BKW_A        234 VDMEVRKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQN--DDG------NYQTQAIS-IHNQPRKVT 304  human
Q7QH71        495 IHLEDHKTSILIPRNRYEQMVKVVDGSSEQLMAVGGNFSKLADGHLVCIQN--TESgcpeatQYTTQAID-IESQPRKVT 571  Anopheles gam...
XP_974100     728 IHMEDKNTTVTIPSNRYDQVMKSMNNSSDHILAFAGNFSCLADSHLVCIQD--TQSne---nTYSTHAIN-IHNKPRKVT 801 
XP_002428675  469 IHMEANQTSILIPKNRYDQVVRALKNSNDPVLALAGCFSCEADAHLVCMQSkgTEI------TYSTQAIN-INEKPRKVT 541 
2_pfamImport   81 IHMDEKQIMVLLPRNRYDQVSRLVLASNRGILAFGANFSAVADSHLVCVQStkDDG------NYNTQAIN-IHNKPRQIT 153 
XP_002114870 1704 VHLEKRKVTITMAMDQHDKILKVLSKSDERVLAFGANFSPLADSVLVCTQT---DG------AYKAQIMS-RPGYDRNTI 1773
EFX65324      297 VHMEEKETNILLPKSRYQQVCKALAQSNDHVISLAASFSPQADAHLVCLQL--DDG------SYQTQAIN-IHTRPRKVT 367 
EDO36159      194 IHMEETTTTIQLPQDRYDEVNKTQNKARKR------------------KQHktRPGnvndlqKKKTGKVKnIQNKARKVT 255 
XP_011146277 1189 IHLKNRTTDVMFPKNRYDQVIKGLHNSNDHVLAYASNFSISADSHLVCIQT--NTGde---sNYQTQAIN-IHNKPRTVT 1262
XP_009013449 1458 IHVEEKKTTVIVPAYNINQVRKLVSDSDEHVVAISGNFSSMADSHLVCLQN--SEL------NYQTQAIN-IQGRPRSVT 1528
4BKW_A        305 GASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKAD--A---------EEPQE----- 368  human
Q7QH71        572 GASFLVLDGSLKPNSGLTGRCTILEDGLRVLIPPVKLQLVKEALKAMKDYQIVCGPTEg-D---------DSQKE----- 636  Anopheles gam...
XP_974100     802 GASFIVFNGALKSSSGLTAKSSIVEDGLMIQIPSEHMTQIRESLRNMKNHTIQCGCIN--A---------TS-DE----- 864 
XP_002428675  542 GASFVVLNGALKTTSGVAAKTSIIEDGLMVQVPRDTMTSLRNKLRNMEDWSVKCGPIE--G---------RNAEE----- 605 
2_pfamImport  154 GASFIALNGDLEDE--VSTRWRIVEDGVMVNMSSQKMALLRDALRLMKDFELNCG---------------TNDEQ----- 211 
XP_002114870 1774 GANFIVLNCSLKSDSSSRIKTTIVEDGIMMQLNTDANRCIRDAISNMTDCTVE-GHIA------------TNDEApltte 1840
EFX65324      368 GASFLVLNGALKSSSGISGRSSIVEDGVMVQLLPDMLSNLKQALIRMENYTIQCGKII--D---------DQPEE----- 431 
EDO36159      256 GASFIVLTGSLKTSTPNTAKVSIVEDGLMVQMVPESILALRKALREMHDFTIKTSPST------------SNTVQ----- 318 
XP_011146277 1263 GASFIVINGALKSSMGLSAKSSIVEDGLMVEIMPEKMEALKAALKNMQDFSIGCGRQG--A---------SEPDE----- 1326
XP_009013449 1529 GASFIVFNGALKSSLGMRAKSSIIEDGLMVQLTPDDMVRLKQALLNSTSFTIKCGLLKptDathdagsavADTDD----- 1603
4BKW_A        369 --HIHIQWVDDDKN-VSKGVVSPIDGKSMETITNVKIF----HGSEYKANG-KV---IRWTEVFFLENDDQHNCLS---- 433  human
Q7QH71        637 --LVSIEWTSNDLN-FNIGVTSPIDRKAFDGVPSIRVH----RGTDYSNSN-HI---IRWTEVFILKGDEESNHPG---- 701  Anopheles gam...
XP_974100     865 --TVNIVWGEPDSN-FNVGVFSPIDNKSMEGIPSIRVH----NGKDYVNGG-RF---IRWTEVFIVQNEGEASRNQ---- 929 
XP_002428675  606 --VVKIIWCEDDKN-FNVGVKSVIDNMALDGVPSIRVH----SGKDFMGST-KL---IRWTQVFIIKCEDGATSAKl--g 672 
2_pfamImport  212 --TVIFHWTEDDVN-FNIGVKSCIDGRLLDGVYSIRVH----NGVDYSGKR-HF---IRWTEVFVIQCEETSDRVD---- 276 
XP_002114870 1841 ddLVVIKWTPSDCT-ANLGVISHVDGMSLAGIKSLDIY----EPVLNKKKS-KTkaaLRWTKLFYLDSGSGGHAEI---- 1910
EFX65324      432 --TVTLKWVDQEPSpVNLGVQSPIDGRSFTGISSIRVM----QPRDFKGEGhRL---LRWTELFVIQIEDSARSSSnrie 502 
EDO36159      319 --SVNMVWVSRNVS--SESHVSPIDGTVLTEVPSIRVH----SSCDFTRREvYR---IRWSHVFLKRGIDNPSRGV---- 383 
XP_011146277 1327 --TVNIKWVDNDTL-FNLGVKSPIDGQPMDGIPSIRVH----NGTDYKGAT-RF---IRWTEVFLIKSDDHSNGVS---- 1391
XP_009013449 1604 --VVEIKWMSTRPD-KTFDIRSPIDGLNLSSYPCVQLHnnsnNKKHLHKSS-KLnldIICVCLYYLHKNQKSSPFPsdls 1679
4BKW_A        434 DPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQ-VGYQAGSNGQ-PLPSQYMNDLDSALVPVI 506  human
Q7QH71        702 DPINMSKISETVAKTACKALVEYLDLLASNGHTKLALRISSNRGQ-MAYVAGSGGN-QLAPLYSNALGQAVMELL 774  Anopheles gambiae ...
XP_974100     930 DPIDISKVSETIAKATCTALVKYLDLLISNSFYKIGIRANLNALF-VAYCAGSNGV-KLPPIYMESLDNELVPVL 1002
XP_002428675  673 DPLEVNNLSESIARATCIALIKLLDLLAASGLTILAVRATMDQEN-VGYEAGSNGE-KLAPIYMNSLDNELIPVL 745 
2_pfamImport  277 EPLDTSRTAESISKATCTALVPLLDLLSAASLTPLALRIVINPDS-VGYEAGSGQN-KLPPLYMQSLDEHLVPVV 349 
XP_002114870 1911 ----ATTFAEMLAQAIHSALEPSEELFVAKSIREFAVRVTLDGEThTEYKAGYRGQ-PLPEELIEQFDECLIPLL 1980
EFX65324      503 DNGDITRFAETLAKAASVALAAKLASLEPHTL--IGLRVSLDGDS-VEYQAGAGQT-SLPNACVEELDSSLIPIL 573 
EDO36159      384 SSRGLSRLTGDLARACCEALRAHLPGLYEGGRTCLALRVTMDTET-AEYAIGAKQE-PLPAEIMVDLDNALVPAM 456 
XP_011146277 1392 DPVDVSKLSGNIAKATCVALVKLLDLLATAGLTKLGVRATIHPDN-VGYEAGSEGT-KLPPIYMNSLDNELIQVL 1464
XP_009013449 1680 SDAELEKVVGDLIHCCRKAMFAELSTAKCSSHTRVCLRIHVGLDQ-IGYETGTNSSiKLSQSCLFTLDDTIIPLL 1753
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap