Conserved Protein Domain Family
DcpS_C
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pfam11969: DcpS_C (This model is not part of the current CDD release)
Scavenger mRNA decapping enzyme C-term binding
This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.
Links
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Statistics
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PSSM-Id: 519995
Aligned: 63 rows
Threshold Bit Score: 85.3388
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001643409 171 SWVNEIlyEDVEADRVVYKDfsed-skrDGFVILPNTKw-------DGvnlDSLYLVAIVYRnDLTSVRDLKPSDRDWLI 242
A0EGQ1       118 DWVYNIleKKKEVENIVFEN--------QTFLILKDYVf------vNSqslDDLHLLALPFQrDIKSLRDLNQDHVAMLE 183 Paramecium tetr...
XP_002638501 148 NWVYNCleKRSEVDKIVYEDpd----knNGFLLLQDIKw-------DGktiENLYVLAIIHRhGLKSVRDLTGDDLEMLY 216
XP_048580917 151 QWVYNIleKKAETERVVFEDgd----peTGFVLLPDMKw-------DQqqvENLYLIAICHKrGIKSLRDLNEEHIPLLK 219
XP_002940683 159 QWVYNIleKKAEAERIVYENpd----paNGFVLIPDFKw-------NQkqvEDLYLIAICHQrGIRSLRDLNADHLPLLM 227
Q6C6M8        30 KWADGVlyRDESPQDVIYGDld----qkTGFVLFIHQKw-------NErdfRELNLIAIAYRhDVHSLRDLVPDHVDWLQ 98  Yarrowia lipoly...
XP_001272646 149 NWVFNIleGRTEQEDVILRDagk--gpdDGFLMLPDLNw-------DRktmGSLHLLGLPLRrDIWSLRDLKKKHVPWLR 219
XP_001543935 141 NWVYNIieGRKEQEDVIIRVsd----peEGFLLLPDLNw-------DRktiGTLRLLCLVERrNIWSLRDLKKKHIPWLK 209
XP_001419684  99 AWVRKIlsLEKERERLLHCDddfllnvdSKWTTHPDCDgadratwrAHssvTDLYCLGLCVReDFKSLRDARAEHLPLLR 178
NP_001027822 169 QWVYNIleKKAEAERIVYEDpd----pdVGFVLLPDFKw-------NQkqvDDLYLIAIVHQkGIRSIRGLTAEHLPLLK 237 torafugu

XP_001643409 243 NINNKIRSIVPACYNYgvHADELRIFVHYQPSYYYFHIHIVNIKHAGLEDNMAAG 297
A0EGQ1       184 EMYTEGLKIISEKY-Ql-ESKFVKVFVHYLPSFYHFHVHFTHSSQMG-----QAF 231 Paramecium tetraurelia
XP_002638501 217 NIRDKSLTAINEKY-Gl-QKDQIKCYFHYQPSFYHLHVHFINLKYDAPAST--TM 267
XP_048580917 220 NILNKGRDAIRTKY-Nv-PHSQLRIYVHYQPSYYHFHVHFTHLKFDAPGLG--SG 270
XP_002940683 228 NILEEGKEAILKRY-Gi-TGNKLRIYLHYQPSYYHLHVHFTVLGHDAPGSSVERA 280
Q6C6M8        99 SMRNQVVNILPEIYGIkmKSMQPVLYVPYPPGKYHFHFLIREKSSPILQEELRSG 153 Yarrowia lipolytica
XP_001272646 220 YLRQRLLEGTVKMYPEl-EQDQLKLYVHYQPTYYHFHIHVVNVMLEA-GATQATG 272
XP_001543935 210 HMREKVLDGVVNVYPQl-DRDQLKLYLHYQPTYYHLHIHVVNIMLEG-GTTQSTG 262
XP_001419684 179 AMLRKGRAVIEDIY-Gv-NAEEMRVFVHYPPQFYHFHVHYQALSAKEQGCA--CE 229
NP_001027822 238 NVFQKGKEAIMKKYe--lPASKLRVYLHYQPSYYHLHVHFNMLGYEALGCGVERA 290 torafugu
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