Conserved Protein Domain Family
Bmt2

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pfam11968: Bmt2 
25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2
This entry represents Bmt2 and its homogues. In Saccharomyces cerevisiae, Bmt2 is a nucleolar S-adenosylmethionine-dependent rRNA methyltransferase that is responsible for the N-1-methyl-adenosine base modification of 25S rRNA.It specifically methylates the N1 position of adenine 2142 in 25S rRNA.
Statistics
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PSSM-Id: 371825
View PSSM: pfam11968
Aligned: 24 rows
Threshold Bit Score: 267.193
Threshold Setting Gi: 144580778
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDN06451  17 RDLDRQIAAHGGLESYQLASKKGQSKERGGDSSKVLVEWLAPVFEELNLQRRKpqnqgggasgasgtgdgkgdpkaekge 96  Histoplasma capsula...
Q6FY66   113 GYIQREIRD-GGLKNYQMASKIGQDKDRGGDSSKLLVKWLKELNYDQHTE------------------------------ 161 [Candida] glabrata
P38278   125 gYIMNQINKLGGLETYQIASQNGQLKERGGDTSKLLEKWIRSSFENCPGA------------------------------ 174 Saccharomyces cerev...
EDO19274 111 GYIMNEIHERGGLKDYQLASRVGQDNNRGGDSSKKLIEWLKEIDVPMDRT------------------------------ 160 Vanderwaltozyma pol...
Q6CTN6   111 GYICGEIEEDGGLQNYQFASTVGQDSNRGGDSSKQLVKWCKELGVDKALG------------------------------ 160 Kluyveromyces lactis
Q757I7   110 GYVMAEINGPRGLQNYQAASTVGQTASRGGDTSRQLVPWLREAGTPAD-------------------------------- 157 Eremothecium gossypii
Q9UUH2    51 KNVESELENI-GIDAYQRASRSGQAEGKGGDSSKILIKWIRTTPCFSYCARLKe-------------------------- 103 Schizosaccharomyces...
EDO37491   3 SEITAKMEQLGGLDAYQKASKLGESRHGGFNAAKWVVGELKAHNIRSELQAGEecstst--------------------- 61  starlet sea anemone
KIS71311 144 DEIQAGLDSLGGLAQYQAWSLTGSAKAGQTPTSKWCMEALATVYKHDRDLPK---------------------------- 195 Ustilago maydis 521
Q6BZX8    68 TQIDSEMEKLGGLEVYQKASLKGQDQTRGGDSSHVLLKWLKNEGNELALEEGQe-------------------------- 121 Yarrowia lipolytica
EDN06451  97 ekprrpppLRLLEVGALSTSNTCSRVSLLD-VIRIDLHS--QEKGILQQDFMERPLPTCDEEKFHIISLSLVLNYVSNSA 173 Histoplasma capsula...
Q6FY66   162 --------LRALEIGSLSVSNHISRCKIFEeVERIDLNSn-DPKGIKRQDFMKRPLPRTGEEKFHLISCSLVLNFVNTPA 232 [Candida] glabrata
P38278   175 ---------VALEIGSLSSGNRISRCALFRnVVRIDLE---EHEGVIKQDFMERPLPRNENDKFDLISCSLVLNFVKNHR 242 Saccharomyces cerev...
EDO19274 161 --------MTALEIGSLSSKNYISTCGIFRnVVRIDLENngDETGVEKQDFMERPVPSKEEDKFNLISCSLVLNFVPTPS 232 Vanderwaltozyma pol...
Q6CTN6   161 --------MNALELGSLSAKNHISVCGLFNpVVRIDLNSn-DTVNIERQDFMKRPLPKDESQRFDLISCSLVLNFVPTPL 231 Kluyveromyces lactis
Q757I7   158 --------ARALEIGALSAANCISTCGLLRtVVRIDLHSn-DSTAIEEQDFMLRPLPQADADAFDLISCSLVLNFVPTPL 228 Eremothecium gossypii
Q9UUH2   104 -------pKDLLEIGSVSVDNKCSTCGLFR-VSRIDLHS--VHPLIKQQDFLER-TP--EEGLFTGISCSLVLNFAP-PE 169 Schizosaccharomyces...
EDO37491  62 ---gnsekLRLLDVGAL--DHNYKKHGWID-CTPIDLNP--QNSSIKKMDFLQ--LK--TKELFHVIVLSLVINFEGDVN 129 starlet sea anemone
KIS71311 196 --------FRVLDVGAI-TGTAYEKYRWVD-ATYIDLHP--QGDNVQKYSFFEFPVPTDTKQRFNMVALSLVINFVGDVR 263 Ustilago maydis 521
Q6BZX8   122 --------KKLLEVGCLSVSNAVSKSTEFDtIDRIDLRS--NDPLIKQQDFLKRPLPKSDQEKYHVISLSLVLNFVPVTA 191 Yarrowia lipolytica
EDN06451 174 SRGQMLKRTTAFLTPPPPliattgdaasenapdeqsnnsAHLPSLFLVLPAACVLNSRYFTEERLRALMSSLGYEMVQRK 253 Histoplasma capsula...
Q6FY66   233 ERGQMCQRFSEFLFPPTS---------------------DVPSYVFVVLPLPCVNNSRYMTIDHFTMIMDSLGYELIRSH 291 [Candida] glabrata
P38278   243 DRGAMCHRMVKFLKPQGY--------------------------IFIVLPQACVTHSRYCDKTLLQNLLGSIGLIMLNSH 296 Saccharomyces cerev...
EDO19274 233 QRGDMCVRFQDFLKKDKIn-------------------nGKGSFIFIVLPLPCINNSRYMNKDNFIKLMNHLGYNILKEY 293 Vanderwaltozyma pol...
Q6CTN6   232 QRGQMILRFKQFLKCNKK------------------------TYLFLVIPLPCLTNSRYMTKDRFNEIMHALGYRKIRFK 287 Kluyveromyces lactis
Q757I7   229 ARGEMLLRFRSFLRGPRP-------------------------LLFIVLPLPCMENSRYMNSEYFCNMMTALGYNCLYQR 283 Eremothecium gossypii
Q9UUH2   170 LRAKMLLHCTGLLMPPNK---------------------EQPPWLFLVLPSPCITNSRYMDEKTLHSIMIQFGFICRQKS 228 Schizosaccharomyces...
EDO37491 130 KRGQMLKKCCKLLHPGGH--------------------------VVIVLPLPCVTNSRFFSAEVLHLMMESLGFVDVSQH 183 starlet sea anemone
KIS71311 264 KRGEMLRHVHKYLPDNQD----------------------TPGFCFLVLPLSCLTNSRYMNQSHLRAILSSLGFNVVKQS 321 Ustilago maydis 521
Q6BZX8   192 DRGKMLQLTTKFLHPQGL--------------------------LFFVLPKACVENSRYLDGELFDSIMASLGYEKLEET 245 Yarrowia lipolytica
EDN06451 254 VTLKLVYYLWKY-----------SVDg------VPRASVFKKEILNPGGNRNNFTV 292 Histoplasma capsulatum NAm1
Q6FY66   292 TSHKLFYCLLRL-----------SHR--------ESKRKFQKKEINPGPGRNNFAI 328 [Candida] glabrata
P38278   297 QSNKLYYCLYQL-----------QVVp------PQPSSFSKRIKVNDGPGLNNFGI 335 Saccharomyces cerevisiae S288C
EDO19274 294 EAKKIIYFLFEM-----------KNQgtkyrnnHENNEFDHKIKLYDKPGMNNFTI 338 Vanderwaltozyma polyspora DSM 70294
Q6CTN6   288 EAKKVAYWLYEL-----------EQSentmcssQNMNQFAKKAKLLDKPGMNNFSI 332 Kluyveromyces lactis
Q757I7   284 SAKKLIYFLFAS-----------RTGmp----aPYPLKYTRKHQLADGPAMNNFSI 324 Eremothecium gossypii
Q9UUH2   229 ISKKIAYYLYSY-----------ECF-------PMKEIDWKKKIVNDGATRNNFFI 266 Schizosaccharomyces pombe 972h-
EDO37491 184 TSKRLYFEMFQK-----------RGK--------LSPKPFPRKIIRKGDGHNNFCI 220 starlet sea anemone
KIS71311 322 DSNKLSRWLLQRkplkerqeaaaNNGnaaaasdEWDGTVFKKRDINPGKDRNNFAI 377 Ustilago maydis 521
Q6BZX8   246 TTDKLIYQLWRC-----------RQE-------KAKYQKFTKNEVRSGSTRNNFCI 283 Yarrowia lipolytica
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