3SUC


Conserved Protein Domain Family
Peptidase_G2

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pfam11962: Peptidase_G2 
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Peptidase_G2, IMC autoproteolytic cleavage domain
This domain is found at the very C-terminus of bacteriophage parallel beta-helical tailspike proteins. It carries the enzymic residues that induce autoproteolytic cleavage to bring about maturation of the folding process of the helix in a chaperone-like manner. The domain thus mediates the assembly of a large tailspike protein and then releases itself after maturation. These C-terminal regions that autoproteolytically release themselves after maturation are exchangeable between functionally unrelated N-terminal proteins and have been identified in a number of bacteriophage tailspike proteins.
Statistics
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PSSM-Id: 371823
View PSSM: pfam11962
Aligned: 6 rows
Threshold Bit Score: 261.307
Threshold Setting Gi: 82011146
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3SUC_A 562 NLILSSYGINTTGS---YKVNGGFE--------KINweldslngRIKARDTVTGGNTW----SDFAQYFESLGGQVI--- 623 Bacillus virus phi29
Q84443  54 TIFKTEANRNSSTAfnhISCTGSNG--------NVF--------RVRGDGTTYGVGAFqtsgADYAEMMEWEDKNPTfed 117 Paramecium bursaria C...
Q5WIE3 560 SMVLASNLVANPNG---YSVVGGYGasgnpssaNIKwelnsrtgTVRAAGTLSSAQTF----TDYAEYFESIDGNPI--- 629 Bacillus clausii KSM-K16
Q5WIC4 651 SLVLASGSVLNNEN---YCISMGAGngdp-strNAKikmytaqgNLRYTGTSEGGSTF----SDYAEYFESHDGQKI--- 719 Bacillus clausii KSM-K16
Q894K1 436 SIIVASECVKDDGL---QTIVGGYGygep-stkNKKweissysgTIKATGAITGNSTF----ADFAEYFESTNGKAI--- 504 Clostridium tetani
O34433 593 RTILSSENIILEEP---YTVAGGHQ--------SIKwlldsvrgNGTFAGAIS--SSL----GGYGEYFESSTGQLI--- 652 Bacillus subtilis sub...
3SUC_A 624 ETGYLVTLEK-GKIRKAEKGEK---IIGVISETAGFVLGESSFEWQGAVLKNEFGGIIYEEVT------TE--------- 684 Bacillus virus phi29
Q84443 118 RRGYPVVLSGnGKIRIASLSDDynnIIGVVSSNPSMLADTAWDQWEGKYLKDKFGMRLSNTIYylanisNEneftrvgpm 197 Paramecium bursaria C...
Q5WIE3 630 ATGLLVTLDG-DKIRVAEEGDD---ILGAISETAGVVLGESALYWQGRYLTNEFGGMVYEPQTirtydvDE--------- 696 Bacillus clausii KSM-K16
Q5WIC4 720 DTGYLVSLVG-NKIKKADKGEE---IIGAISETAGTVLGSAAFSWQDRYLKNEFGGYIYEKKAlreydlDE--------- 786 Bacillus clausii KSM-K16
Q894K1 505 PTGIIVTLDG-DKIRPCRQGEE---MLGVISETAGVLLNACGFHWQDRYLKNEFGGLVYEKKY------DE--------- 565 Clostridium tetani
O34433 653 HTGTIVTLRG-EKIVPANVGDY---MLGVISETSAFISGASSFVWQGRYLTNEFGGFIYETVT------DE--------- 713 Bacillus subtilis sub...
3SUC_A 685 ----DGVKFkrp--------lpNPDFDPNKN--YIPRSQRREWHVVGLLGQIAVR--------------IDETVKQGHsi 736 Bacillus virus phi29
Q84443 198 ttppQGYFIktsp-----eyilNPKYNPNVA--YVERNDRPEWDPVGFVGKLRVRngclvhpswkplkvIDDYADVGN-- 268 Paramecium bursaria C...
Q5WIE3 697 ----DGNTLptyteevvelpleNPQYDPSLP--YTPRSKRQEWNIVGLTGQIHVR--------------VSDSVQPGDyv 756 Bacillus clausii KSM-K16
Q5WIC4 787 ----DGNQLdtykevlvdmpkeNPDYDPQRE--YEPREDRDEWHIVGLVGQVHVR--------------IDNTVEAGDki 846 Bacillus clausii KSM-K16
Q894K1 566 ----ETKQYikv-------fkeNLEHDMKEE--YIAREDREEWNVVGLTGQVYVR--------------IDETVVTGDfi 618 Clostridium tetani
O34433 714 ----ESGELirv-------pkqNPDYDTALEanYHSRAARDEWHVVGLVGQHYVR--------------IDETVNQGDyl 768 Bacillus subtilis sub...
3SUC_A 737 d-avgGVATDGDNf-----iVQEITTPYTKEKGYGVAIVLVK 772 Bacillus virus phi29
Q84443 269 -----AAAQVTEY-------LIGVTPNYTLSKKVEDLEQTIN 298 Paramecium bursaria Chlorella virus 1
Q5WIE3 757 k-angGIGVPGENgp---ikVMRLTKAYDEDKGYGIALCFIK 794 Bacillus clausii KSM-K16
Q5WIC4 847 s-aigGIATKDDEgq---fiVMNITTPYSEEKGYGVAVVFIR 884 Bacillus clausii KSM-K16
Q894K1 619 ksdnlGRATKDDNptytrwrVMEVTTEYSDSKGYGVALVFIK 660 Clostridium tetani
O34433 769 t-ahnGIGTKATEgs---wkVMKITSAYTSEKGYGIALTVIK 806 Bacillus subtilis subsp. subtilis str. 168
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