Conserved Protein Domain Family
KCNQC3-Ank-G_bd

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pfam11956: KCNQC3-Ank-G_bd 
Ankyrin-G binding motif of KCNQ2-3
Interactions with ankyrin-G are crucial to the localization of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localize sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3, that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localized to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3. KCNQ3 is a major determinant of M channel localization to the AIS, rather than KCNQ2. Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3).
Statistics
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PSSM-Id: 403240
View PSSM: pfam11956
Aligned: 10 rows
Threshold Bit Score: 138.811
Threshold Setting Gi: 47209353
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O43526        768 QEDtPGCRPPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLD-----ALNSCYAAVApcaKVRP-YIAEGESDT 841  human
XP_008108402  698 NED-VTAKHPESALRDSDTSISIPSVDHEELERSFSGFSISQSKENLDv----LNNGCYTAVA---KIRP-YIAEGESDT 768  green anole
XP_006639510  743 hpraedGKQHDSALRDSDTSISIPSVDHEELERSFSGFSISQSKENLDf----LNNAYFGGVAlcaKVRP-YIAEGESDT 817  spotted gar
OCA15305      556 veegsgkhRDPAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLEi----LNNGAVAGPGpchKVRP-YIAEGESDT 630  tropical claw...
XP_005993541  673 raeeAPVRPHDILLRDSDTSISIPSVDHEELERSFSGFSISQSKENMDi----LNTGIFSGAApcaKRRP-YIAEGESDS 747  coelacanth
PKK34356      627 YSDkVSPRQRRSLTRDSDTPLSLLSVNHEELERSPSGFSISQDRDDFPfg--------pNGGSawmREKr-YLAEGETDT 697  rock pigeon
XP_005457717  730 LQDlSVGLGRTTGGQGGDSPLSMLSVNHEELERSPSGFSISGEREGENi---sMGAGLAPGDPgwtRPRPsYLAEGETDT 806  Nile tilapia
XP_020567051  722 LQDlSAGPGRTTGRQGGDSPLSMLSVNHEELERSPSGFSISVDREGDErv--pTEADMATGEVswtRPRPsYLAEGETDT 799  Japanese medaka
CAF94891      686 LQDqAGGVARTTGGRGADTPLSMLSVNHEELERSPSGFSISGERDGED------GGGPSAGATvrtRARPtHLAEGETDT 759  spotted green...
XP_023191081  718 LQDlSAGRGRTTGGRGGDSPLSLLSVNHEELERSPSGFSISGEREGEAgldlpMGAAVAAGEAswtRTRPsYLAEGETDT 797  southern plat...
O43526        842 DSDLCTPC-GPPPRSATGEGpFGDVGWA 868  human
XP_008108402  769 DSDLCTPC-GPPPRSATGEGpFSDMGWS 795  green anole
XP_006639510  818 DSDLCTPC-GPSPHSATGEGaYGDRGWS 844  spotted gar
OCA15305      631 DSDLCTPC-GPPARSTTGEGpYGDMGWP 657  tropical clawed frog
XP_005993541  748 DSDLCTPS-GPPPRSSTGEGpCGDMGWS 774  coelacanth
PKK34356      698 DTDPFTPS-GSMPLSSTGDG-ISDSIWT 723  rock pigeon
XP_005457717  807 DTDPFTPSgGPLPLSSTGEG-FGDAVWT 833  Nile tilapia
XP_020567051  800 DTDPFTPSgGALPLSSTGEG-FCDAEWn 826  Japanese medaka
CAF94891      760 DTDPFTPSgGPLPLSSTGEG-Fefsaes 786  spotted green pufferfish
XP_023191081  798 DTDPFTPSgGALPLSSTGEG-FGDAEWN 824  southern platyfish
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