Conserved Protein Domain Family
XTBD

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pfam11952: XTBD 
XRN-Two Binding Domain, XTBD
XTBD is a family of eukaryotic proteins that act as an XRN2-binding module. XRN2 is an essential exoribonuclease in eukaryotes that processes and degrades a number of different substrates. XTBD is found on a number of different proteins to link them to XRN, such as PAXT-1.
Statistics
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PSSM-Id: 403236
View PSSM: pfam11952
Aligned: 39 rows
Threshold Bit Score: 60.7495
Threshold Setting Gi: 528485954
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8BI72        20 ETLRCEGETDKHWRHRREFLLRNAGDLvpatdetadaesgartrQLQQLVSFSMAWANHVFLG--CRYPQKVMDKILSMA 97  house mouse
XP_005170350  21 EAFRGFSESDKHWKGRREFIFRNMADFpe--------------pQVDHLLALSMVWQNHVFMG--CRYSSELLQRVMEMA 84  zebrafish
XP_004076108  21 ETFRGYWESWKHWEPRREFILRNMSDFes--------------gQVDHLLSLSMVWANNVFLG--CRYSSELLERVKAMA 84  Japanese medaka
CAG08802      21 ETYRGYWESDKHWEARREFILRNIKDFpp--------------eQLDQLLSLSMVWANKVFLG--CRYSTELLDKVVEMA 84  spotted green p...
Q21738         8 EAEKKLWESDDAWELRKAFMLAHYDDY-----------------PKIQLQCLSQLFINVTLLG--CEYSQTLMQKIRTMG 68  Caenorhabditis ...
XP_001629431   4 EAYS--WETDFQWRSRRNFIETWRDEY-----------------PEDRLASLAMCWSNMKFFG--CRYPEKVESLVNEME 62  starlet sea ane...
EFX73990       9 diiRKPYERDLQWNMRRAFIERNEEKT-----------------DRRKLLQLSDNLMKMEFVGqqIRYPIKVYHELHNLA 71  common water flea
NP_001012905  15 EQWRQYSESERHWAVRRRFILRHLHSYpg--------------aAIDQLLALSVLWSNHVFMG--CRYGSQVMEKVLKMA 78  chicken
XP_005807254  21 ETFRGYWESDKHWEARREFILRNMSDFea--------------dRLDHLLSLSMVWANNVFMG--CRYSAALLEKVKEMA 84  southern platyfish
XP_028451919  21 ETFRGYWESEKHWQARREFILRNISDFed--------------pHLDHLISLSMVWANNVFLG--CRYSTELLEKVKEMA 84  yellow perch
Q8BI72        98 EGI--KVTDAPIHT-TRDELVAK 117 house mouse
XP_005170350  85 EGI--EVEDAPVFK-TRDEIIRQ 104 zebrafish
XP_004076108  85 EGI--VVDEAPIFK-TRDEIMKN 104 Japanese medaka
CAG08802      85 EGI--DVADAPVFR-TRDEIMKN 104 spotted green pufferfish
Q21738        69 AGIaaNKDRTKTGSyVKASAAKK 91  Caenorhabditis elegans
XP_001629431  63 SKCp-PVPKPEKRPpKRSIIIEN 84  starlet sea anemone
EFX73990      72 GNLweEFRREKKLArIRDYMCQR 94  common water flea
NP_001012905  79 EGI--DIGEMQTFElVPSKKLKR 99  chicken
XP_005807254  85 DGI--MVEDAPVFK-TRDEIIKS 104 southern platyfish
XP_028451919  85 EGV--VVEDAPVFK-TRDEIMKK 104 yellow perch
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