Conserved Protein Domain Family
WASH_WAHD

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pfam11945: WASH_WAHD (This model is not part of the current CDD release)
WAHD domain of WASH complex
This domain forms part of the WASH-complex of domains and proteins that activates the Arp2/3 complex, see pfam04062. The Arp2/3 complex regulates endocytosis, sorting, and trafficking within the cell. The WAHD domain attaches to the FAM21 proteins via its N-terminal residues and to the microtubules via its C-terminal residues.
Statistics
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PSSM-Id: 519979
Aligned: 8 rows
Threshold Bit Score: 325.191
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001995142   9 HSAYQVSIIPTDLQHEETIIRAAQSLDCLNKTINSIFGRIDARLARNGVHVQLINERVLRAQAKINALVGSKKSIKIYAP 88 
XP_006004516   9 GQVYSVPLIQPDLRREEAIHQITDALQYLQRVSDDIFSRVLERVESNRTRLQGVSDRITIAQARIKKIKGSRKATKVFSS 88 
A4IG59        12 GQVYSVPLIQPDLRREEAVHQITDALQYLEMISTDIFTRVSESVEKNRAHLQSVTDRIKLAQARVQKIKGSKKATKVFSS 91  zebrafish
Q28DN4         9 SQAYSLPLILPDLRREEAIHQITDTLQHLQTVSNDIFSRILQRVETNRGQLQRINGRLSLAQAKIERLKGIKKAIKVFSS 88  tropical clawed...
XP_002113304   3 IQKFAVPIITTDLRREESLRQTADVLQHVEKVCNDTFDHVVQRVEDVKKKLEAIENRTKVAKAKIDKIRTSTKATTILSA 82 
XP_001025407   8 IQHNKITMSNTDMSQYEGLEKTLSNLSMLDETLSYVIQRFDNQQNQYKNKIQQYLDRIHICQKKIAALQEQKKAITFVSP 87 
ETN65114       1 MHTYSVPVIKHDMRHEETVLDAINALEYLNEVVNDVFGKINGRIERNRERLQALDARIEKAKDDVRRLHDAKEAIIIYSP 80 
B2RYF7        12 GQVYAVPLIQPDLRREEAIQQVADALQYLQNISGDIFSRISQRVELSRRQLQAIGERVSLAQAKIEKIKGSKKAIKVFSS 91  Norway rat
XP_001995142  89 ARFPGtSTLNINISATFpqvvdhqkptsmetSTSSAAAVPAEFSQRRRHTNNL--------------------------- 141
XP_006004516  89 AKYPA-PERLQEYSSIF--------------MGVEDAATLKRPRYKVQSKHRPl-------------------------- 127
A4IG59        92 AKYPA-PEKLQDYSSIF--------------TGAVDPASQKRPRIKVQSKLRPl-------------------------- 130 zebrafish
Q28DN4        89 AKYPA-PEHLQEYSSVF--------------AGAEDGWLAKKLRHKIQSKHRPl-------------------------- 127 tropical clawed...
XP_002113304  83 NKYPV-ADIMTNYESLFa-------------SIDSELGELKRSHYRITNDIMPf-------------------------- 122
XP_001025407  88 ------SSFVQKYKFTHenkksi---lqdykQKHNISKFETQFGYQLKNDPEQvgpiidnsrpddlyqilnisygkfksr 158
ETN65114      81 SRYPA-SDMEATVEPTFt-------------ATNGIRM--PECSYRLKDKPYq--------------------------- 117
B2RYF7        92 AKYPA-PEHLQEYNSVF--------------TGALDPGLQRRPRYRIQSKHRPl-------------------------- 130 Norway rat
XP_001995142 142 ------NDALEEQPSgaeldtvFFHVRGE-EQLETPLVVERqqtnrmaGLGTLPE-TKSVPTLMRFNTNEfayaggqdgn 213
XP_006004516 128 -----eEKLLQEKLM-------YFPVYLN-TKHQEENEGEE-------GLGSLPRnVRSVSSLLLFNTNE---------- 177
A4IG59       131 -----dDKAQQEKLM-------YLPVCVN-TKKRSEDETEE-------GLGSLPRnVNSVSSLLLFNTTE---------- 180 zebrafish
Q28DN4       128 -----dEQAVQEKLK-------YFPVCVN-TRGQDEESAEE-------GLGSLPRnISSVSSLLLFNTTE---------- 177 tropical clawed...
XP_002113304 123 -----nEKLIDESPK-------IELPNARhRINMVEDQLDE-------GLGGLPTdLTSVSSLLLFNSQE---------- 173
XP_001025407 159 eknpveNRKLPLKEK-------FF------------------------GVGTYPKkIKCAESLLVLNTNI---------- 197
ETN65114     118 -----pSHSLQEKIQ-------FYHVKTVrDGCERIFPFERstkahrlGNRE-RHqTAYLDELLLYGDGAy--------- 175
B2RYF7       131 -----dERALQEKLK-------YFPVCVS-TKSEPEDEAEE-------GLGGLPSnISSISSLLLFNTTE---------- 180 Norway rat
XP_001995142 214 edlNAWKR--TLPPQRSSHKRATPAVAARSSALLAPAPHSLSHGTIKLATPAGDLRYTPAALAAPAIDVPLDLP---DLP 288
XP_006004516 178 ---NLYKKyvLLDPLAGAVTKTHNTLETEKEEKPFDAPLSITKREQLERQTAENYFYVPDLGQVPEIDVPSYLP---DLP 251
A4IG59       181 ---NLYKKyvFLDPLAGAVTKTHTTLETEKEDKPFDAPLSITKREQLERQTAENYFYVPDLGQVPEIDVPSYLP---DLP 254 zebrafish
Q28DN4       178 ---NLYKKyvFLDPLAGVVTRTNPALEGEDEEKLFDAPLSITKREQLERQTAENYFYVPDLGQVPEIDVPYSLP---DLP 251 tropical clawed...
XP_002113304 174 ---NPYKKyiTLDPLAGAVTKTRSTIEQE-ANALGDAPVTISQRQGMERKPMESYFYVPNLGDVPEFDVPSFLP---NLS 246
XP_001025407 198 ---NPYRKyqQIDNLIIDESKQQQRVKPDDTNQINLQVAPVGISNQLTAYQRSELTYVP---ETKKVDNAVSIPldfGLD 271
ETN65114     176 --vREYKG---QDWKRSTLRKGSVHGNVIREERIMSTSSPMIRSKV--KKKTQDLFYTPSLSDAPKLDVPIDLP---DLP 245
B2RYF7       181 ---NLYKKyvFLDPLAGAVTKTHTMLGTE-EEKLFDAPLSISKREQLEQPAPENYFYVPGLGQVPEIDVPSYLP---DLP 253 Norway rat
XP_001995142 289 GIANDLQYEpVEEQTPIAPSHQFVD-LPDLPGLNEN-EPEPQPEDEKAIEM 337
XP_006004516 252 GIAADLMYS-ADLGPGIAPSVPGSN-MPELPTFYTE-PTYVNGQDQQYTGA 299
A4IG59       255 GIADDLMYS-ADLGPGFAPSVPASNsIPELPSFGTD-HDESSGSDSQFKLE 303 zebrafish
Q28DN4       252 GVADDLMYS-ADLGPGIAPSAPGVP-IPELPTFITEdITENSRTDSQDGRL 300 tropical clawed frog
XP_002113304 247 GVADDVTFD-VDNEISIAPSAGFV--FPDLPTVETT-PVPTANGGTEAAAP 293
XP_001025407 272 GVAEDFDID-YGGQDLIQPSAWLIQ-NPTLPDPYAN--AQPSSQSQNQNNQ 318
ETN65114     246 GIVSNINY--VGSNTLIAPSLQLAGiIEQLPSLEDL-TSAIDVADHHTDAT 293
B2RYF7       254 GVADDLMYS-ADLGPGIAPSAPGA--IPELPAFHTE-VAEPFQPEREDGAL 300 Norway rat
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