Conserved Protein Domain Family
DUF3456

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pfam11938: DUF3456 (This model is not part of the current CDD release)
TLR4 regulator and MIR-interacting MSAP
This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family.
Statistics
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PSSM-Id: 519974
Aligned: 62 rows
Threshold Bit Score: 75.847
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4Q576        60 DCSACITVARTLFERL---NQTlAENPSTYLISHRLGKKNq---LRRRQYRNSELLVTEVMENVCtS--YKNDaRLLRLH 131 Leishmania major
XP_006342149  63 KCSACSAIAEELEHGL---LKE-KPRNHLDMR-HRLDSKGqr-eGKLIDYRGSELRVVELLDDLC-E--KMQD-YTLEKV 132
XP_002273352  24 KCAACNAVAEELEFGL---SNE-KPRNHLDMR-HRLDSKGqr-kGKVIDYRVSELRVVELLDGLC-E--KMQD-YTLEKI 93 
CAL9147695    34 KCAACNAVAAEIEIGL---SNE-KPRNHLDMR-HRLDSRGqr-eGKVIDYRVSELRVVELLDGLC-E--KMQD-YTLEKL 103
XP_003062266  22 KCSACEAVANELQAAL---ERE-RPRNHLDMRG-RIDSKGvr-yGKLIDYKISELRFVELLEDLC-T--DVGNnFQIFDA 92 
XP_001418449  22 KCSACRAVGKSLAKALredAES-ADGKVVDMRG-RLDSRGrr-yGKRISYKVSELRFVELLDGVCdEpsRVGK-YQLHEE 97 
Q017C7        27 KCSACRGVGKSLADALrndEKE-SEGKVVDMRG-RLDSRGkr-yGKKISYKESELRFEELLENVC-A--DDGK-VSELQF 99  Ostreococcus tauri
XP_002507790  31 KCSACAAVAGQLQTAL---EAE-KPRNHVDLRG-RLDSKGvr-yGKLIPYDVSEQRFTELMEGVC-E--GLGR-YTLRTV 100
XP_002121886  58 NCHVCRLMVEEIKHSL-------KGEADLTEEQLKEKKRKdrrkSKAERKREKALPMLVAIEEVC-N--SMLG-YLPQQA 126
XP_015623521  32 KCAACKAVAAELEIGI---SSE-KPRNHLDLRN-RLNSKGqr-eGKVIDYRVSELRVVELLDGLC-D--KMQD-YTLQKL 101 Japanese rice
Q4Q576       132 PKSKVRlyhqqvfGDTRLGVRhAlRE-DEVYPaDADPAAWAEKLDGQlypiarlySRRDADalqglqslsatptmCALLV 210 Leishmania major
XP_006342149 133 DSSTNT---------------------------WIKVNNWDLLKTNKqear-ahsKAMSSF--------------CGRLL 170
XP_002273352  94 DSTRRE---------------------------WVKVDDWDNITTNKqear-aysKDISSY--------------CGRLL 131
CAL9147695   104 DSGEQA---------------------------WIKVRDWNSIEGDKqear-aysKDLSSF--------------CGRLL 141
XP_003062266  93 DAPKKR--------WRTFAKKlKiKGaRAKAMr----------------------AEISGY--------------CHRLV 128
XP_001418449  98 TNR------------------------WRIPP-NPVKKIRHARGKQMk-------TEILGY--------------CHRVI 131
Q017C7       100 HEETA--------RWRKPPN-----P-VKKIR-GARAKAMk--------------AEIMGY--------------CHRVI 136 Ostreococcus tauri
XP_002507790 101 KPSEGPsagtdvmRWENIGR---------VSK-NPRAKTLr--------------DELNDY--------------CHRIV 142
XP_002121886 127 DKTKFRyvkshdlKEVNSLIKsQeENdNAADElARKYDAYRHPETNR----------LLAM--------------CDEII 182
XP_015623521 102 ESGE--------------------KG-------WVKVADWNSFKTEKkaaarahsKNLSSF--------------CGRLL 140 Japanese rice
Q4Q576       211 EEFEDEIESLVKSVRSLe--ETEHSLCG--------MTLP 240 Leishmania major
XP_006342149 171 EQTEDELAELIKKGSVKv-gDVTKVLCEd------lSNYC 203
XP_002273352 132 EETEDELADLIKKGSVKt-gEVSKVLCQd------lSKHC 164
CAL9147695   142 EETEDQLAEWIKRGSAEs-gGVSKALCQd------lTEHC 174
XP_003062266 129 EEQEEALQAKLYANELNa-tNVDEILCVe------lSKEC 161
XP_001418449 132 EESEEALQAAVLEERLDaesNVEEFLCRn------vSKAC 165
Q017C7       137 ESAEDALREAVYQSTIDg-sTVEEFLCRn------vSKEC 169 Ostreococcus tauri
XP_002507790 143 EKQEEDLQKALYAKELNs-tNVAEKMCIq------fSGEC 175
XP_002121886 183 NREENNLMRWNTNEEKE---DLFDYLCRnrvftvedSDEC 219
XP_015623521 141 EETEDELSEWIKTSSAEs-gNVSRALCEd------iSKHC 173 Japanese rice
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