4IMI


Conserved Protein Domain Family
SYMPK_PTA1_N

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pfam11935: SYMPK_PTA1_N (This model is not part of the current CDD release)
Symplekin/PTA1 N-terminal
This is the N-terminal domain found in the symplekin protein from animals and PTA1 protein from budding yeasts and is typically between 239 to 261 amino acids in length. Symplekin is a scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. PTA1 is involved in pre-tRNA processing. PTA1 is a subunit of the cleavage and polyadenylation factor (CPF), which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. This domain has the ARM or HEAT fold, with seven pairs of antiparallel alpha-helices arranged in the shape of an arc. It is important for interaction with Ssu72 and stimulates Ssu72 C-terminal domain phosphatase activity in vitro.
Statistics
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PSSM-Id: 519973
Aligned: 90 rows
Threshold Bit Score: 110.391
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4IMI_A       104 SAQVIKRVIQACGSIYKNGLQYLCSlmepGDSaEQAWNILSLIKAQILDMI------------------D-NEn---DGI 161 fruit fly
Q6CY28        88 DYVTYKNCILCLGNIYDRLFDLVAK----TSD-DKLWSVMLKFKELIIANWktcypl-------dlsdnDlNNhsrgTGV 155 Kluyveromyces l...
XP_003646644  93 DYITYKNIILGFGSCYGSLFDLVAK----TSN-ESLWKDMVLLKDLVLQNWkscfp--------leptdPlKDharsLGA 159
XP_003683493  91 DSIAYKYSVLAFSASYPLLFELVAK----TSN-QEMWDTMQQMKAFILSKWnttyplq----lnsddndPfLNdrknIGS 161
XP_001645135  91 DLSTYKHCIYTFAACYAMLFDLVAK----TSN-QNLWNTMQEMKNFIISNWnttyplp----snttefgIlLDkpvnIGS 161
Q6FIS3        94 DPVTYKYAILSLTSSYSSLFDLVAK----TSN-QELWDTMQELKSFIITRWrtpypksks-neqvddssMlAQenenIGC 167 [Candida] glabrata
Q01329        91 DVLVYKNIVLIMCASYPLVLDLVAK----TSN-QEMFDQLCMLKKFVLSHWrtayplratvddetdveqWlAQidqnIGV 165 Saccharomyces c...
XP_003673693 101 DPVTYKTAVLTFANAYPLLIDLISK----TSN-EDTWKIMTSFKKFIISNWdttypl------tdlnsiDlNNdvknLGC 169
XP_003959536  97 DPIAYKYTILSLTISYPLLLDLVAK----TSN-DKLWTLLTRFKDKIIKNWrlnqsnk----lkpeisdDlNDdsknIGC 167
XP_003688242  92 DELVFKNCTFAFAKCYPMLFDIVAK----TSN-QKLWDSMQEMKQFIISKWsppynsas--lsmmfvdtIlLDlpknIGS 164
4IMI_A       162 RTNAIKFLEGVVVLQSFADEDSLKR---------DGDFSLADVPDHCTLF-RREKLQEEGNNILDILLQ-FHGTthissv 230 fruit fly
Q6CY28       156 KLASVKLISKIIIVHTSG-PG----------------ISVGSIPENHPVIsNKQALEAEAKYLLDKLLTfLIEEpmmcap 218 Kluyveromyces l...
XP_003646644 160 NLASVKLISKIVIVHTQG-TG----------------ISISTVPNNHPVIkNKQGLEAESKKLLDVLITfLIDEpmmiap 222
XP_003683493 162 RLATAKFLSEIIIVHTSRngn----------nikAGPISISSVPDGHPVIsNKQQLESEAKKFLDILLNyLIEEpmmvss 231
XP_001645135 162 KLATAKFISEIVIVHTSSSSSSSSSssssrngvvTT--SISSVPSNHPVIkNKAQIESEAKKLLDVLLNyLIEEplmiap 239
Q6FIS3       168 KLATLKLISEVIIVQTPIISSSTIKdksg--hmnM--ISLASVPDNHPVIsKKQVYESEAKKLLDSLLNyLVEQpfmism 243 [Candida] glabrata
Q01329       166 KLATIKFISEVVLSQTKSPSGN-E-------------INSSTIPDNHPVL-NKPALESEAKRLLDMLLNyLIEEqymvss 230 Saccharomyces c...
XP_003673693 170 KLASVKFISQVIIVHITPTDMDENSs-----------MKNVIIPNNHPVLgAKKNLEREAKKYLDLLLNyLVEEvmmcse 238
XP_003959536 168 KLATVKFLSQIVITQTVIndns---------pnnSYPISITSVPNNHPVIsNKPKLETEAKNCLDLLLNyLIEEpmmiss 238
XP_003688242 165 KLAIAKFMAEVIIVQTSATPSSSSGssnksntdvQTDVSISSVPNSHPVIsNKAQLDAEAKKLLNLLLNyLVEEpimvpt 244
4IMI_A       231 NLIACTSSLCTIAKMRPIFMGAVVEAFKQLNA-------NLPPtlTDSQVSSVRKSLKMQLQTLLK-----NrgaFEFA- 297 fruit fly
Q6CY28       219 WFTGALHSLSFIMKQRPLATIRIASALLKFNIdmkfqrdDEPTlqYRLAKRFVERCYRNLVQFGIKsqllkN---SGSM- 294 Kluyveromyces l...
XP_003646644 223 LFCSILNCLAFIMKQRPLATVRILSGLLKFNIdlkyqqdDEPTlqFRMAKRFVERCYKNFVNFGMKtqlikN---TGTL- 298
XP_003683493 232 VFIGILNCLAFIMKQRSQATMRILSGLLKFNVdakyqadDLSVlnYRLGKRFVERCYKNFVQFGLKsqiikN---SGQM- 307
XP_001645135 240 VFVGIINCLSFIMKQRPHAAIRISSALLKFNIdakfqcdSMSPlnYRLSKRFVERSYKNFVQFGLKaqlikN---SGQM- 315
Q6FIS3       244 IFVAIINCLAIVMKQRPQTTIRILSGLLRFNVdakfqmdNQSTvnYRLAKRFVERAYKNFVQFGLKgqyikN---TGTT- 319 [Candida] glabrata
Q01329       231 VFIGIINSLSFVIKRRPQTTIRILSGLLRFNVdakfpleGKSDlnYKLSKRFVERAYKNFVQFGLKnqiitKslsSGSG- 309 Saccharomyces c...
XP_003673693 239 LFMGIINCLAFIMKARVRTTVRILSAILKFNIdakymveGMTPlkFRLCKRMIERCYKNFVQFGMKhqlikKd-mTGTIf 317
XP_003959536 239 AFIGVLNCLSFIMKARSQTTIRILSALLRFNVdgkyqldDKSAvnYKLSKRFVERCYKNFVNFGIKnqlikNgsqSNSM- 317
XP_003688242 245 MFMGVIDCLSFIIKSRPQSAIRISSALLRFNIdakfqikETSSlnYRLSKRFVERSYKNFVQFCLKaqlikN---SGQM- 320
4IMI_A       298 ----STIRGMLVdlgSSTNEI 314 fruit fly
Q6CY28       295 ----TQYRNKLAkisQTLFVI 311 Kluyveromyces lactis
XP_003646644 299 ----APYHSKLGkiaQTLHMI 315
XP_003683493 308 ----ASQHMKLSkisQTLHVI 324
XP_001645135 316 ----SNIYTKLAkisQTLHGI 332
Q6FIS3       320 ----STFYTKLSkisQTLHVI 336 [Candida] glabrata
Q01329       310 ----SSIYSKLTkisQTLHVI 326 Saccharomyces cerevisiae S288C
XP_003673693 318 gdnaVDFYSKLGkisQTLFGI 338
XP_003959536 318 ----NQMYSKLSkiaQTLHVI 334
XP_003688242 321 ----STIYTKLSkisQTLHVI 337
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