6J8E,6J8G


Conserved Protein Domain Family
Na_trans_cytopl

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pfam11933: Na_trans_cytopl 
Cytoplasmic domain of voltage-gated Na+ ion channel
This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Statistics
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PSSM-Id: 403218
View PSSM: pfam11933
Aligned: 33 rows
Threshold Bit Score: 96.8263
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6J8E_A              557 SGEEek--nDRVRKSese-dsiRRKGFRfSLEg-sRLTYEK-RFSS-----------------------PHQ--SLLSIR 606 
14_pfamImport         6 SIRS-----DSLSQG-------RPT----------TASSRNrKVSAvkrmeyrsgvgrtddvqfpfacqDNQteASLSLP 63  
Q16Z69              473 SIRSeg--lESVSEI-------TRTTAPtATA---AGTAKArKVSA----------------------------ASLSLP 512  yellow ...
FlyBase:CG9907-PBE  509 SIRSvevesESVSVI-------QRQPAPtTA----HQATKVrKVST----------------------------TSLSLP 549  fruit fly
NP_001153633        483 SSGTeecgeDRLPKSdse-dgpRAM-------------------------------------------------NHLSLT 512  human
XP_011217229        483 SSGTeecgdDRFPKSdse-dgpRAM-------------------------------------------------NHLSSI 512  giant p...
XP_012820423        485 SETEeygedMKPPRGemdeeslRKM-------------------------------------------------SILGIG 515  tropica...
KFZ69242            151 lgtEeygedQRNPKCdyd-dgqRRM-------------------------------------------------TLLGIS 180  great c...
NP_001233256        482 SSGTdeggeDRFPKSdsd-dgpRRTrsgaglaeart----------------------------qppppslppqALLGVN 532  gray sh...
OXU25269            516 SIRSv----ESISEH-------R-VRISsNNHnvtSTTTKVrKVSTvaragng---------qftyayqESLkeASLSLP 574  Trichom...
6J8E_A              607 GSLFSP---RRNSRAS-LFSFR-GRAK------------------DIGSENDFADDEHSTFEDNDsRRDSLFVPH--RHg 661 
14_pfamImport        64 GSPFNL---RRGSRGShQFTIRnNRSRfappggdrk-plvlstylDAQEHLPYADDSNAVTPMSE-ENGAMVVPMypTGl 138 
Q16Z69              513 GSPFNL---RRGSRGShQFTIRnGRGRfvgvpgsdrkplvlstylDAQEHLPYADDSNAVTPMSE-ENGAIIVPVyyANl 588  yellow ...
FlyBase:CG9907-PBE  550 GSPFNI---RRGSRSShKYTIRnGRGRfgipgsdrk-plvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyyGNl 624  fruit fly
NP_001153633        513 RGLSRTsmkPRSSRGS-IFTFR-RR--------------------DLGSEADFADDENSTAGESEsHHTSLLVPWp---- 566  human
XP_011217229        513 HGLSRTsmkPRSSRGS-IFTFR-RR--------------------DLGSETDFADDENSTAGDSEsHHTSLLVPWp---- 566  giant p...
XP_012820423        516 f--gPGsgkRRISQGS-IFNFR-FRNR------------------DLCSETEFADDEVSNA--SDgHRGSLLVPRa---- 567  tropica...
KFZ69242            181 YGPSANlvkRRTSHGS-IFSFR-LRGR------------------DTGSETDFADDEISTAGENEsHRGSLLIPRs---- 236  great c...
NP_001233256        533 HAPLRSslkRRSSHGS-VFTFR-RR--------------------DLGSETDFADDEISTPGESEsHRASLLVPWp---- 586  gray sh...
OXU25269            575 GSPFNP---RRGSRGShQFTIRnGRGRfagppgsdrkplvlstylDAQEHLPYADDSNAVTPMSE-ENGAIVVPVyyASl 650  Trichom...
6J8E_A              662 -ERRHSNVSQASRAS-RVLpilpmngkmhsavDcngvvslvgg------pstltsagqlLPEg------------TTTET 721 
14_pfamImport       139 tSRHSSYTSHASRISyTSHa------------D--------------------------Llsgla-----ggrglPTKES 175 
Q16Z69              589 gSRHSSYTSHQSRISyTSHg------------D--------------------------Llg------------gMTKES 618  yellow ...
FlyBase:CG9907-PBE  625 gSRHSSYTSHQSRISyTSHg------------D--------------------------Llggmav----mgvstMTKES 662  fruit fly
NP_001153633        567 -LRRTSAQGQPSPGT--SApghalhgkknstvDcngvvsllgag----dpeatspgshlLRPvmleh---ppdttTPSEE 636  human
XP_011217229        567 -LRRPSAQGQLSPGT--SApghalngkrnstvDcngvvsllgtg----daeatspgshlLRPvildr---ppdttTPSEE 636  giant p...
XP_012820423        568 -GRRQSTQSQTSPLSfANTpgytqngkrnssvDcngvvslvggag--tysnptspggllLPAviveks-gaeenaSPTDL 643  tropica...
KFZ69242            237 -GRRPSVQSQVSHSShPTTpnytqtgkrnssvDcngvvsligggtgalnpdptspagllLPPvimekp-gtgdltSPSDE 314  great c...
NP_001233256        587 -ARRPSGQSQPSPGV-PGVpsllhngkrnsavDcngvvsllasr----vpeaaspggslLSSvilekprpppdttSVSEE 660  gray sh...
OXU25269            651 gSRHSSYTSHASRLSyTSHg------------D--------------------------Llg------------nVTKES 680  Trichom...
6J8E_A              722 E-IRKrRSSS-------------------------------------------YHVSMDLLEDPTSRQRAMSIAS 752 
14_pfamImport       176 K-LKSlRSSRnssttvtqqpl---------------------sdknclrdfnnKHQDNQFIE-PAQQQNVVDMKD 227 
Q16Z69              619 R-LRN-RSARntnhsivpppnmsgpnmsyvdsnhkgqrdfdmsqdctdeagkiKHNDNPFIE-PSqtqtvvdmkd 690  yellow fever...
FlyBase:CG9907-PBE  663 K-LRN-RNTRnqsvgatnggttcldtnhk-----ldhrdyeiglectdeagkiKHHDNPFIEpvqtqtvvdmkdv 730  fruit fly
NP_001153633        637 P-GGPqMLTS-------------------------------------------QAPCVDGFEEPGARQRALSAVS 667  human
XP_011217229        637 P-GRPqMLNP-------------------------------------------QAPCMDGFEEPGERQRALSAVS 667  giant panda
XP_012820423        644 ElSRMqLLMP-------------------------------------------HALSVEYVDQPFQRQRAVSTVS 675  tropical cla...
KFZ69242            315 A-SKKqLLMP-------------------------------------------HRPSVDHSDEPFQRQRAVSAVS 345  great creste...
NP_001233256        661 V-SKKqLLMP-------------------------------------------QRLSLEYFEEPHERQRALSAVS 691  gray short-t...
OXU25269            681 R-LRS-RSARppsangnhvtenlq---------------khhyegdtddsfskKQQDNPFIEEPSPQHAVVDMKD 738  Trichomalops...
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