6QX9,6G90


Conserved Protein Domain Family
SF3a60_Prp9_C
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pfam11931: SF3a60_Prp9_C (This model is not part of the current CDD release)
SF3a60/Prp9 C-terminal
This domain corresponds to the C-terminal region of SF3a60 subunit (Prp9 in yeast counterpart) from the highly conserved heterotrimeric complex SF3a found in eukaryotes. It is essential for pre-mRNA splicing that functions in spliceosome assembly within the mature U2 snRNP (small ribonucleoprotein particle). This domain has two conserved sequence motifs: PIP and CEICG. It contains a zinc-finger domain of the C2H2-type which might be important for RNA binding and protein-protein interactions with components of the SF3b complex.
Links
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Statistics
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PSSM-Id: 519969
Aligned: 67 rows
Threshold Bit Score: 156.124
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6QX9_A3      382 NLPLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPKAFQRHFAEWRHAHGMRCLGIPnTAHFANVTQIEDAVSLWAK 461 human
P19736       397 DMPLGPDGLPMPYWLYKLHGLDREYRCEICSNKVYNGRRTFERHFNEERHIYHLRCLGIEpSSVFKGITKIKEAQELWKN 476 Saccharomyces c...
XP_001643396 396 DMPLGPDGLPMPYWLYKLQGLDMTYKCEICANTIYKGRRTFEKHFSETTHNYHLRCLGIEpSSAFKGIVSIKEATDLWGT 475
XP_003675709 396 DMPLGPDGLPMPFWLYKLQGLDVEYPCEICSNQIFKGRRAFEKHFTAPTHQYHLRCLGIEpSSMFKGITKIKEAQKLWVD 475
XP_003681257 398 DLPLGADGLPIPYWLYKLQGLDVEYSCEICTNQTYKGRRAFEKHFLEPTHTFHLKCLGIEpSITFKGITGIQEAQDLWRQ 477
5_pfamImport   1 NLPLGPDGYPIPYWLYKLQGLDIEYACEICGNHVYKGRRIFERHFQEQRHAYGLRCLGIEpSPAFKDIYNIAEAQQLFQS 80 
XP_002552610 386 NLPLGPDGFPIPYWLYKLQGLDIEYPCELCGNFVYNGRRQFDKHFGEQRHVFGLRRLGIEpSASFKGVTKIDDAKQLWSH 465
Q6CIR1       401 NLPLGPDGFPIPRWLIKVQGLDVKYVCEICGNQIYHGRREFEKHFPLKKHSEGLKSLGITpSLAFKDVTTIVEVTELWKA 480 Kluyveromyces l...
XP_003645840 398 NLPLGPDGYPIPYWLYKLQGLDIEYTCEICGNHLYKGRRVFERHFHEQRHTYGLRCLGIEpTSTFKGISKISDAQILWSR 477
6G90_T       397 DMPLGPDGLPMPYWLYKLHGLDREYRCEICSNKVYNGRRTFERHFNEERHIYHLRCLGIEpSSVFKGITKIKEAQELWKN 476 brewer's yeast

6QX9_A3      462 LKLQKA--------------SERWQ-----PD---------------TEEEYEDSSGNVVNKKTYEDLKRQGLL 501 human
P19736       477 MQGQSQ--------------LTSIA-----AVppkpnps-qlkvpteLELEEEDEEGNVMSKKVYDELKKQGLV 530 Saccharomyces cerevis...
XP_001643396 476 MNVKDK--------------SSKHA-----ESn-------------nYEIEVEDKEGNVLSKEIYEELKKQGLL 517
XP_003675709 476 INSQKN--------------SSKPM-----VSsi------------eLQVEVEDSVGNVMSKKLYDELKKQGLH 518
XP_003681257 478 TSSRNR--------------PQTQKk---------------------IDLEVEDQEGNVLTQKVYQELKKQGLV 516
5_pfamImport  81 LQSSTG--------------PAGLA-----TRragaiss--santrkLEVEVEDEDGNVMTHQVYEDLKKQGLL 133
XP_002552610 466 LRSTSS--------------GRVSSeg-------------------kLEVEVEDEDGNVMSKKVYDELKKQGLL 506
Q6CIR1       481 LQAKST--------------LKSGEpfskiSTvke----------peMVLETEDNEGNVMSVQVYEELKKQGLL 530 Kluyveromyces lactis
XP_003645840 478 LKNNSH--------------LNSAS-----ATypdatssravvtnnkLEIEMEDEDGNVMSHRVYEDLKKQGLL 532
6G90_T       477 MQGQSQltsiaavppkpnpsQLKVP-----TE---------------LELEEEDEEGNVMSKKVYDELKKQGLV 530 brewer's yeast
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