Conserved Protein Domain Family
DUF3446

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pfam11928: DUF3446 (This model is not part of the current CDD release)
Early growth response N-terminal domain
Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.
Statistics
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PSSM-Id: 519967
Aligned: 17 rows
Threshold Bit Score: 30.2005
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004080832  95 GKFSIDSPYPA------NWSPDGVINIVS-GIFNMTQpppp-------pppPPSSS----TSSSPASSGSPHhfSSGNLs 156
XP_006631761 101 GRFTLEPAANCs----nSLWAEPLFSLVS-GLVGIAN--------------PPSTSapslSSSGPTQASAAS--HSPPL- 158
P26632        99 GRFTLEPATNCs----nSLWAEPLFSLVS-GLVGINPppasipsstsqathPSSSS----TSSIPSSSSSST--SSASL- 166 zebrafish
7_pfamImport   1 GRFSFEPSVSTcg---nNLWAESLLSL----LVGVAA--------------PPPASs--lPVSSPSVTSSSP--SQPTIs 55 
6_pfamImport   1 GRFTFEPSTSVsg--ggGLWAEPLLSLFT-GLVSMAA--------------SPSTAssslSSVASSVASPAP--QSQPGf 61 
EOA99173      36 GRFSLEPAPNSs----nTLWPEPLFSLVS-GLVGMAN--------------APPTSt--pSSSSPSSSS-----QSPPL- 88 
XP_003223498  99 GKFCIDAQYPGgagavgSYPADGILNLVSaGLLQGLA--------------AAPTS----SSSSSSSSA--A--SSGSP- 155
KAG9268543    66 GKISIDSQFAQg-----SWTQEGLISLVCaDVEGKTT--------------ASSGTt--dLSGAPGSSQGP---EKAPL- 120
2_pfamImport   1 GRFSLEPSGNNgg--phPLWPEPLFSLVS-GLVGMANap----------tlPPLSSs--sSSSAPSSSSSSS--SSSPIl 63 
XP_003976264  87 GKFAFDTPPSGgiggsgWCSDNNIISLVSaGILGVS---------------PSPGT----VTTQTSSAA-----AAASM- 141 torafugu
XP_004080832 157 c---tmAAQSQA-EIDhphHPYSPP-PPY--PSSScP-EVYh--QDP--SAFlSTSTCP-ISSYPS 209
XP_006631761 159 ------SCSVQPsEPN---PIYSAA-PTY--SSAS-P-DVF---PEQa-QPF-PSPSGG-GLQYPP 204
P26632       167 ------SCSVHQsEPN---PIYSAA-PTY--SSAS-P-DIF---PESg-PNF-STTVGT-SLQYSS 212 zebrafish
7_pfamImport  56 s----vQVTCSSaEIT---SVFSAI-PTY--TSAGaE-PLL---P--------ATDSQPaPLAFSP 99 
6_pfamImport  62 aavpvsGCSASGaSGL----------PAY--TSAA-G-PNF---LPPvsISQ-PGLPGL-QPQGSP 108
EOA99173      89 ------SCSVQAsENS---PIYSAA-PTF--PNSS-S-DIF---PEPqtQSF-PNPSGA-PMQYPP 135
XP_003223498 156 ------GTMAPP-EME---HMYS-P-PPY----SScG-ELYhphQQPqeGSYlPAPSGH----FPP 200
KAG9268543   121 -----------SsAME---HMYTAP-PPY-----TcSaDVY---QDP--SAYsSATSCA--VAHPC 159
2_pfamImport  64 lsasssSSSGQGsEAG---PIYSAA-PTFpgPSSGsG-DLF---SE---QPF-SGPQFPpPPAYPS 117
XP_003976264 142 --------GGQTsDME---QVYGPPlPAY----STcS-DLY---QDQ--VSFhHSPATStTLAYPG 186 torafugu
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