5LTH


Conserved Protein Domain Family
HODM_asu-like
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pfam11927: HODM_asu-like (This model is not part of the current CDD release)
Haem-dependent oxidative N-demethylase, alpha subunit-like
This protein family is found in fungi and bacteria, including the alpha subunit of an haem-dependent oxidative N-demethylase (HODM) from Pseudomonas mendocina. This protein, catalytically active, is responsible for haem, oxygen and NADPH-dependent dimethylamine (DMA) binding. It shows structural similarity to the to the Aer2 PAS domain, but lacks the core PAS-domain alpha-helix that forms the Aer2 haem pocket, and displays extended beta-strands and a longer loop. The structure of Ectopseudomonas mendocina Heme-dependent oxidative N-demethylase alpha subunit, PDBe:5lte, shows that it is an haem-binding PAS domain, similar in structure to PAS gas sensors.
Links
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Statistics
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PSSM-Id: 519966
Aligned: 214 rows
Threshold Bit Score: 187.329
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5LTH_A            54 FEHQFDVDEHYVSEMAERARVLELDPGrCL-VmPHMAQAAWDTLAMLMEHLARDYPQHF-RLT-----RQGdaWHWQNLA 126 Ectopseudom...
Q28RG5            31 GAPWLQRDEAFAGQMAVRDQLVAERRAeVIaQmPGCQGAVAELYGAVLRGLAG--CDGYaVGRgacvrPDG----VDVPL 104 Jannaschia ...
WP_013651623      25 PAAWFDPDGHLIAHLDQKARLLAERRDvVFrAePETGAAQAEVLRMLVAHLSEAHPTRY-R-------RAG----DAVIV 92  Polymorphum...
WP_012568915      46 PADWIRLDATWPDLLAERRHLLRERGAeVLlApSGTEVAARDLLHRLASHLPARFPSLY-A-------RDG--RMLLNRL 115 Rhodospiril...
jgi:Acry_2373      8 PAELTAFGADYPAQMAERRALLGLRRAeVFgAlPSSEAARRETLLLVAGHLLADRAPWF-A-------LAG--AMLENRL 77 
Q7NI38            26 PSRWIEIDERFEEYLTLKCRLLTERRGeVLvAmPGSETEQQEVLELLLDHLPEYFPEHY-R-------LKD--SRLENRM 95  Gloeobacter...
WP_023174684      23 LSEWIELDEEYPVYLARKQQLLAQRRDeVLvNlPDSLPEQIEVRDLLIAHLLQRFPEHY-Q-------RSG--QQVDNRI 92  Gloeobacter...
jgi:Ple7327_0018  25 LKDWIEIDERFTAYLARKQELLEHHYReVFaSlPGSERSQKEVLNLLLDYLPKHFPSHY-Q-------RQG--DRIESLL 94 
WP_015189429      24 LQQWIEIDEDFTEELNYKDQLLKEQYSdVCgClPESQAGQQEVLELILEHLLQYFPNYY-Q-------QQG--NYVVNKM 93  Gloeocapsa ...
WP_015954593      27 LSEWIDIDENFISTVTLKAQLLKDKTTeVFtAlPNTIEAQQEILELLLDHLLTYFPQYY-L-------QQG--TILKNLQ 96  Gloeothece ...

5LTH_A           127 LGidQ--RFTFGd-pAslPCEPLEYITRQMQGDFAVLDQRd--GDLFMDAGMVTCPADWSLRFDAGMSFKQWHSPVPMAH 201 Ectopseudom...
Q28RG5           105 DE--G---------------DPLGTLARLVQQDLCVLEKPeggMEHVMSAAILCFPASWSLAEKIGHPLSRIHGPVTEYD 167 Jannaschia ...
WP_013651623      93 TG--AqgATDRRvalDa-DEPPLLTASRLVQEDLVIMRKGe--GGYRLAAASLCFPSSWSLAEKFGQPMAAIHTKVPGFA 167 Polymorphum...
WP_012568915     116 TG--E--SLDVS------EAPPLETACLLVPEDLCLLRre--aGAWRLAAGIVCFPNRWRLAEKAGRGLPGIHEPVPGYT 183 Rhodospiril...
jgi:Acry_2373     78 TG--E--RWNLAa----pECDPLELAGRLVQEDLCLLDpa--tA--TLTAAVLCFPSRWRLADKLGRDLAAIHTPVPLYA 145
Q7NI38            96 SG--E--IWNPAd----hGFAPLELAARLVQEDLCLMRpt--qEGYILSAACVCFPSRWLLTEKVGLLLTGIHAPVPGYA 165 Gloeobacter...
WP_023174684      93 TG--E--SWN-Id----aFASPLELASRLVQEDLCILRpa--tGAYVLSAACVCFPSRWSLVEKLGHPLAAIHAPVPGYG 161 Gloeobacter...
jgi:Ple7327_0018  95 AQ--Q--SWNVAd----fETNPLDLAGRLVQEDLCLMQps--pDGYILVAASVCFPFHWRLQDKLGQPLARIHQPVPEYA 164
WP_015189429      94 TN--Q--KWSLSn----fTNNPLDLAGRLVQEDLCLMQlk--dNEYILTAGSVCFPARWRLREKLGRPLVQIHDPVPGYA 163 Gloeocapsa ...
WP_015954593      97 TN--Q--VFELNy----yKDAPLTLALHLVAEDIFLLQps--eKGYILTAGVACFPFFWRLQDKIGLPIEQIHQPVPEYA 166 Gloeothece ...

5LTH_A           202 Q--MGVFDRalkYLLNIQVGAPVRRLNWTLTINPrlDTSPEtYHeWg----Ndr--gkVTPDNVgrlvHLRVELQLMARL 273 Ectopseudom...
Q28RG5           168 GlmERRVQR---VFDHLREDSPVWRQNALIYDDPqlFQPRR-MDa-----rRpk---pT--GAG----YLRSEKQVLMRL 229 Jannaschia ...
WP_013651623     168 GrmGQVVDR---IFDNLKPDQLVGRLNWSIYDDAdlHHPEP-KQlt----pQieadgaSALAAL----FVRVERQTLRRL 235 Polymorphum...
WP_012568915     184 ErlAIPVDR---FFDTLAPGRGVWRTNWSLNDDPalFQPGE-TA-HlpadaGit--aaTAGDRL----LLRVERQTLLAL 252 Rhodospiril...
jgi:Acry_2373    146 ErlDRPVAR---FIAALAPGRLVERFNWTIHDGSdlFQPEP-HI-Apg--pAvt--agTAPARL----HLRVERQTLSRL 212
Q7NI38           166 EqlAGPVDR---FFERLRVETPMWRINWTIVDSPelFLLPG-GA-Krd--sQit--aqDAAERL----WIRIERQTLRRL 232 Gloeobacter...
WP_023174684     162 EqlARPVDR---FFDRLRVEAPMQRLNWTIVDSPalF-LPP-DH-Pra--aPia--asEAGEHL----WIRIERQTLRRL 227 Gloeobacter...
jgi:Ple7327_0018 165 QklEEPVNN---FFMRLKTDSPGYRLNWGIVDTPdlSLTRP-RN-PrrsdaPft--vdRLGEKL----WLRVERQTVRRL 233
WP_015189429     164 EklEQPVNK---FFDRLKPEFPEYRLNWGIVDSPelFLTQP-HG-FetfgaDit--aeNAGEKL----WLRVERQTLRRL 232 Gloeocapsa ...
WP_015954593     167 GklSKTVNL---YFDHLLSTSPGYRIAWGIVPTPqlVLEQM-QP-Pgw-enTlt--psNIGERL----WLRSEYQTFRRL 234 Gloeothece ...

5LTH_A           274 PRSNALLFGIRTYLISLDELVSNPAw---AQRLHRVMRDLPDPIADYKGITRYRQTLV 328 Ectopseudomonas mendocina
Q28RG5           230 PVTRAVVFSIHTYVVAMEDLt--------ADQRAG-----------------LAG--V 260 Jannaschia sp. CCS1
WP_013651623     236 PDSGDVLFTIKIHHDPIRALEDHPRraelAAGLLTQLLALDVDQLAYKGLTRHRDRIA 293 Polymorphum gilvum
WP_012568915     253 PESGAVVFGIRTYQRPLSRLS--Pa---qARQFAAVLRDVPEDSARYKGLLRTREPAL 305 Rhodospirillum centenum
jgi:Acry_2373    213 PESGAVLFTIRTRQAALAEVMAVPg---aAAALAEAVRGLPETVAAYRGIAPFRAALL 267
Q7NI38           233 AESRTVLFTIRTYVHPLHVLEQQPa---mARALATAVRQIPEPMQLYKSLLPVREALL 287 Gloeobacter violaceus
WP_023174684     228 PTTGAVLFTIRTYVHPLACLEGQPe---mARALAETVHQIPEPMQLYKSILPVREPLL 282 Gloeobacter kilaueensis
jgi:Ple7327_0018 234 ETSNCVLFTIRTYIYPLSILESYPa---iAQNLSAAIQQMPLAMQRYKDILPVREVLL 288
WP_015189429     233 PKSGSILFTIRTYVYSLKFVVRDRq---iASQLAAVIQQIPPQMQIYKNILPIKNPLL 287 Gloeocapsa sp. PCC 7428
WP_015954593     235 PHSGGIVFTIRTFVNPLSTLKSMPs---mAHNLATVIREMPPETQAYKKIQPFLNPLL 289 Gloeothece citriformis
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