Conserved Protein Domain Family
NFACT-C
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pfam11923: NFACT-C (This model is not part of the current CDD release)
NFACT protein C-terminal domain
This is the C-terminal domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins involved in the ribosomal quality control pathway. This context is conserved in archaea and eukaryotes, but NFACT proteins in bacteria lack the NFACT-C domain.
Links
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Statistics
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PSSM-Id: 519964
Aligned: 117 rows
Threshold Bit Score: 96.4299
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KLJ05556      999 SAADLSCLPSLIGTAVAGDEIVAAIPVCAPWMALGQYKYRAKLQPGTLKKGKAVKEIYGKWVVdattavnamekgkgrrk 1078
EFJ34356       11 EREKLTELDALTGRSFPNDILLYAVPVCG-YSALQNYKYHVKITPGPSKKGKGAKMAMDAFIR----------------- 72  
XP_017229197 1030 EKDQQNDADYLTGNPLPNDILLYAVPVCGPYNALQSYKYRVKIIPGTSKRGKAAKMSVNLFSQ----------------- 1092
EOY06825      997 EKGRLNDVDYLTGNPLPSDILLYAVPVCGPYSAVQSYKYSVKIIPGTAKKGKAAKTAMNLFSH----------------- 1059
XP_005647447  917 DKDKLQELDSLTGQPRPDDVLLYAIPMCAPYSAIQSYKLKVKLTPGTQRKGRAGRQAIELLSR----------------- 979 
XP_002958634    5 DAARLSVLDSLTGIPRPEDVLLFAVPVCGPYNAIQSYKYKVKVTPGTVKKGKAARQALELLTR----------------- 67  
XP_005849505 1048 ERDKLTQLDQLTGVPRGEDILLFAVPVCAPYQVLASFKFKVKIIPGTLKKGKAARQAAELLLK----------------- 1110
XP_009524486  913 EAEGADFFDAFTGEPLADDIVLFAMPMCAPYASLIKFKYKVKLTPGSQKKGKAAKQAMEHFFAsnfkdekdan------- 985 
XP_024578165  278 EAENVDFFDAFTGEPGPNDIVLFAMPMCAPYTSLTKFKYKVKLTPGGLKKGKAAKQAMEYFFSsnlke------------ 345 
XP_004988054  828 LTQSLSNLHSLTAQPTPEDTVLYALPVCAPYSATQGYALRAKLVPGNTKKGRAIRGVVQTFVS----------------- 890 

KLJ05556     1079 ekdegeaevgeedvnervDGEEGKGEDgtthgLKQLARME--LELIKGWREVEIMNTLPVSKVKIV 1142
EFJ34356       73 ------------------------SSD--------VLPRE--KELMKAVAESDLVACMI-GNVKVS 103 
XP_017229197 1093 --------------------------------MPEATQRE--KELMKACTDSEIVAAII-GNLKVC 1123
EOY06825     1060 --------------------------------TPEASNRE--KELMKACTDPELVAAII-GNVKIT 1090
XP_005647447  980 ------------------------AAD--------ISGRE--RELLKAIPEMEVINAMV-GNVKLA 1010
XP_002958634   68 --------------------------------GSEVPPRE--REVLRALPEMEAITALVGPGVKLS 99  
XP_005849505 1111 --------------------------------GGEASQRE--RDLLRAVPEQEAISCLCGKGVRIQ 1142
XP_009524486  986 --------ksapyrpggaEAEDEAQPD--------VNPIVvqRELMRCIPENELVNCMV-GPVKIS 1034
XP_024578165  346 -------------eknanRPMSDIHDDc----QPDVNPVVvqREHMRCIAENELINCMV-GPVKIS 393 
XP_004988054  891 --------------------------------GGQCTEEQ--ASLITAIKDADLYNGVP-TRVKVM 921
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