Conserved Protein Domain Family
ANKRD13_C

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pfam11904: ANKRD13_C (This model is not part of the current CDD release)
ANKRD13 C-terminal
This domain, and the associated ANK family repeat pfam00023 domain, are found in ANKRD13 of which at least 4 subtypes are known to exist, termed A-D. ANKRD13C act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2. ANKRD13A/B/D are ubiquitin-binding proteins that specifically recognise and bind Lys-63-linked ubiquitin. They positively regulate the internalisation of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Statistics
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PSSM-Id: 519953
Aligned: 80 rows
Threshold Bit Score: 156.263
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006854269  189 RADMTLAGFDG-LRIQRSDQSVLFLGDG--SedgrapPGTLCMVSHKDKEVTnaldGAGIRATDAE-------------V 252
KAF8356933    158 RIDTTLVGFEG-HSWQRGSQSFIFRLEDe-V------NPQLILIDHEAGSAT----IQSLVADETLgyf--------epT 217
2_pfamImport    1 RIDTTLASFDDeTHWVRVNQSFVFRLNAegF-------AEFVTIDHDEKVAD----------VQALrddhsf--eyfnpI 61 
EGT35741      159 RIDTTLVSFEG-ANWIRGNQSYMFRLSDqgF-------AEFIVLDHDERIAA----------VQELrdddif--neyrpL 218
XP_003111624  159 RIDTTLVSFEG-ASWVRGNQSYMFRLSNdgY-------AEFIVLNHDERIAV----------VQELrddevi--neyrpL 218
Q7QE32        157 RIDTTLLGFDN-NTWQRGNRSYIYKG-Qs-K------TASMIEIDHDTGEVS----------VEHMrniedenidgirpS 217 Anopheles gamb...
XP_002016389  231 RLDTTLVDFND-MKWERGDISFLFRGEAppR-------EALVLLDNEQACYQ----RLRHEEAD---------------M 283
XP_002006273  226 RLDTTLVDFND-MRWDRGDISFLFRGEAapN-------ESLVLLDNEQQCYQ----RLRYEESD---------------M 278
Q7Q159        146 RLDTTLVDFSD-MRWERGDISFIFKGDNppK-------DSLTALDNECRCYQ----HVRHEETEME-------------I 200 Anopheles gamb...
24_pfamImport   1 RLDTTLVDFTD-MRWERGDISFIFRGDKnpT-------ESLTVLDNEYKCFQ----RIRHEESENE-------------I 55 
XP_006854269  253 AQEVAAMSQTNMFRPGIDVTQAVLLPQL----TW-RRQERSETVG-QWKAKVYDMHHVVVSVKSRkvpgamsddeffntc 326
KAF8356933    218 EDATFLRMTSPISTTYIDIEKIGFERSKggilSWiGASEKKEKVA-GYDCKVFNASNVELVTKTR--------------- 281
2_pfamImport   62 EGDMAFRMNNPISTSYIDVDNIGFERTSrgflSWfTSPESTESVQ-GYECKVLSASNVHLVTKRR--------------- 125
EGT35741      219 PGAMEDRLNNTISTTYIDVDNIGFERTSrgflSWfTSGESNETVD-GYDCKVLNASNVHFVTKRR--------------- 282
XP_003111624  219 PGAMDDRLRNPISTTYIDVDNIGFERTSrgflSWfTSGESNETVD-KYECKVLNASNVHLVTKRR--------------- 282
Q7QE32        218 REAVNLRLQAPVICNHIDMDKISFERNKsgfwGW--RSEKVESIN-GYECKVYGASNVKFITRTR--------------- 279 Anopheles gamb...
XP_002016389  284 EDEVDGLMSTDIMATQMSTKTINFARAQs---GWiFRANRKELIGgQYQCELYTIQGLIIKQRKR--------------- 345
XP_002006273  279 EDEVDVLMSTDILATQMSTKTIQFARAQr---GWlFRANRKELIGgQYQCEIYTIQGLVLKQRKR--------------- 340
Q7Q159        201 EDEVDILMSSDILAAQMSTKGISFTKAQs---GWiFREDRRETVAgQYDSDLYTINGLTLEQRKR--------------- 262 Anopheles gamb...
24_pfamImport  56 EDEVDVLMSSDILAAQMSTKKINFSRAQt---GWfFRADRKELVAgQYNSDLFTINGLVLKSRKR--------------- 117
XP_006854269  327 nendtesegyEDVLTEEEKKQ------------------LEMALKmgspengddgfsdm--vvshrhscyeqrdVFIEGG 386
KAF8356933    282 ----------SEHLSEADRAR------------------FK-----------------------------------QDEN 298
2_pfamImport  126 ----------MDHLSANRRAE------------------LENNGK-----------------------------SIDTKA 148
EGT35741      283 ----------YDHLTREARDR------------------LAQEE------------------------------ASESKA 304
XP_003111624  283 ----------YDHLSHEARER------------------LAQEE------------------------------ASESKA 304
Q7QE32        280 ----------NEHLGS-EQAR------------------VK-------------------------------------NS 293 Anopheles gamb...
XP_002016389  346 ----------REHLSHEDLQKnraiiesmrssvvqpdgrRSSLNSqttdtttdsnnpaapngitlpelprrsslQAPPAS 415
XP_002006273  341 ----------REHLSHEDLQKnraive-------titkgGNHTDSnaattpngsnl-------tlpelprrsslPPPPTT 396
Q7Q159        263 ----------REHLSRDDLQKnkalme-------sltkgGQGQQGgidqnge---------------iyrreslQPPPNC 310 Anopheles gamb...
24_pfamImport 118 ----------REHLSSDDLQKnkmlve-------sftkgSNSSSGsltpngslkne--------pyevsrrsslIPPPET 172
XP_006854269  387 EHSDGVSCEVKQEKKGWFGHWGKrgvkSNeghpkkfapprssvcmdekvsdllgdstiqsrpgrhsvevgvrgDEFrrvr 466
KAF8356933    299 SNPLSSILNMVRTETGGV----E----G----------------------------------------------TA---- 320
2_pfamImport  149 MAGLKKFISHTKTDE----------------------------------------------------------------- 163
EGT35741      305 VSSFKKMMSTNKTDE----------------------------------------------------------------- 319
XP_003111624  305 VASFKKMMSTNKMDE----------------------------------------------------------------- 319
Q7QE32        294 RTPLQHFLGMTEEDYDHAAVAGSstsaLRggeqppppsapsspcn-------------ngsedrtpdgaegecSGT---- 356 Anopheles gamb...
XP_002016389  416 SVTWDQYLEAAVGRCprl-------------------------------------------------------------- 433
XP_002006273  397 TVTWSQYIEAPVGKCpql-------------------------------------------------------------- 414
Q7Q159        311 EVTWQDYVSAEPGQYpnl-------------------------------------------------------------- 328 Anopheles gamb...
24_pfamImport 173 NVTWEDYINAEVGEMpsi-------------------------------------------------------------- 190
XP_006854269  467 ETKDGkkfastses-----------shkrvkdgNRESEYKKGLRPVLWLSPNFPLST-EELLPLLDILA-NKVKAIRRLR 533
KAF8356933    321 EHVGEpdlieyfdee--------atmkrdigrqRNVMRKSNSFKATLWLAEQYPLCLqEQVAPIVNLMS-SSSAHFSRLN 391
2_pfamImport  164 NTKRNlleeglsaeqyfyp-qyefepksdigsaREVERKSTGFKATLWMADDYPLNLnDQIVPIVELMA-VNSSHFARLH 241
EGT35741      320 NTKRDlfaegaitpdqyldpnyefepgcdigkaREVVKRSNAFKATLWMADEYPLSLhDQIIPIVELMA-VNSPHFARLH 398
XP_003111624  320 NTTRDlfaegltpdqyldp-nyefergcdigkkKEVVRRSNAFKATLWMADEYPLNLhDQIIPIVELMA-VNSPHFARLH 397
Q7QE32        357 -AQEaapsaeeyfsd-------vdlngrdvgkpKRITAKEQMFKANIWLSEEFPIKLqEQVLPILDLMStMASPHVSKLK 428 Anopheles gamb...
XP_002016389  434 ------------------------------grpLVNKQSSKTLRATVAMSTDFPLSV-EMLLDVLEVV--APLKHINKLR 480
XP_002006273  415 ------------------------------graPVNKQSNKTLRATVAMSTDFPLSV-DMLLDVLEVV--APLKHINKLR 461
Q7Q159        329 ------------------------------greLVYKESSKNFKATVAMSKDFPLSV-DMLLNVLEVI--APFKHFSKLR 375 Anopheles gamb...
24_pfamImport 191 ------------------------------grkMVYKESSKHFKATVSMSTDFPLSI-EMLLNVLEVI--APFKQFTKLR 237
XP_006854269  534 ELLTTKLPPGtFPVKVAIPVVPTIRVIVTFTKFEELQ-PLEEFCTPpssplpgrlvgrespsisanysngswfqwIKVPY 612
KAF8356933    392 TFMRMQLPAG-FPVKIEIPLFHVVSAKITFGRINEPG----QFVTPlpagatvps------------gadstdgvPLLAA 454
2_pfamImport  242 KFIRLQLPAG-FPIKIEIPLFHIVSARVAFQNVNVAGkYVtple------------------------------------ 284
EGT35741      399 NFIRLQLPAG-FPVKIEIPLFHIVSARIAFQNVNSPGkHVipl------------------------------------- 440
XP_003111624  398 KFIRLQLPAG-FPVKIEIPLFHIVSARIAFQNVNTPGkYVtpid------------------------------------ 440
Q7QE32        429 DFITMQLPSG-FPVKIEIPLFHVLNAVVTFGNVFAIEnPVPHVS--------------------------------HIRE 475 Anopheles gamb...
XP_002016389  481 NFVTLKLPTG-FPVKIEIPVLHTVTAKVTFQKFEFTNs------------------------------------------ 517
XP_002006273  462 EFVTLKLPTG-FPVKIEIPVLHTVTAKVTFQKFEFRDn------------------------------------------ 498
Q7Q159        376 EFVTLKLPSG-FPVKIDIPILPTVSAKITFQKFEFRDd------------------------------------------ 412 Anopheles gamb...
24_pfamImport 238 EFITLKLPSG-FPVKIEIPILRTVSAKITFQRFDFQDn------------------------------------------ 274
XP_006854269  613 RqgssginspssrVEDIQDPFAIPSDYT 640
KAF8356933    455 Dgas-------paVEIDPRVFDIPDGYR 475
2_pfamImport  285 ----------gnnVFIEDAAFQIPAGYS 302
EGT35741      441 ----------ddsVLIEDEAFEIPQGYI 458
XP_003111624  441 ----------dqnVEIDENAFRIPGGYV 458
Q7QE32        476 Sder-------vtCVIDDACFEAPSGYG 496 Anopheles gambiae str. PEST
XP_002016389  518 ---------------IPDKLFEIPSNYW 530
XP_002006273  499 ---------------IPAKLFEIPAHYW 511
Q7Q159        413 ---------------ISPDLFVIPEDYK 425 Anopheles gambiae str. PEST
24_pfamImport 275 ---------------ISEELFEVPSDYV 287
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