Conserved Protein Domain Family
GPCR_chapero_1

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pfam11904: GPCR_chapero_1 
GPCR-chaperone
This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.
Statistics
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PSSM-Id: 403196
View PSSM: pfam11904
Aligned: 92 rows
Threshold Bit Score: 146.626
Threshold Setting Gi: 303288524
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006854269        189 RADMTLAGFDG-LRIQRSDQSVL--FLGd--gSedgrappGTLCMVSHKDKEVTnalDGAGIRATDAE-----------V 252 Amborell...
7_pfamImport          1 RIDTTLASFDDeTHWVRVNQSFV--FRLnaegF-------AEFVTIDHDEKVAD----------VQALrddhsfeyfnpI 61 
EGT35741            159 RIDTTLVSFEG-ANWIRGNQSYM--FRLsdqgF-------AEFIVLDHDERIAA----------VQELrdddifneyrpL 218 Caenorha...
XP_003111624        159 RIDTTLVSFEG-ANWVRGNQSYM--FRLsndgY-------AEFIVLNHDERIAV----------VQELrddevineyrpL 218 Caenorha...
CUT99623            103 RLDTTLLDFKN-RSWVRGQLSII--VDGnkpfE-------SRTCLIDHEHRSYQildGTMARENSDEW-----------L 161 Echinoco...
XP_002016389        231 RLDTTLVDFND-MKWERGDISFL--FRGeappR-------EALVLLDNEQACYQ----RLRHEEAD-------------M 283 Drosophi...
WGS:AAPU:GI20952-PA 226 RLDTTLVDFND-MRWDRGDISFL--FRGeaapN-------ESLVLLDNEQQCYQ----RLRYEESD-------------M 278 Drosophi...
Q7Q159              146 RLDTTLVDFSD-MRWERGDISFI--FKGdnppK-------DSLTALDNECRCYQ----HVRHEETEME-----------I 200 Anophele...
2_pfamImport          1 RLDTTLVDFTD-MRWERGDISFI--FRGdknpT-------ESLTVLDNEYKCFQ----RIRHEESENE-----------I 55 
XP_004226058        171 RMDSTLEDFSE-RRWIRGDISIIidFAAdgepD---------VLLLDNKNKIYQh-mKQTTVQEREAS-----------I 228 vase tun...
XP_006854269        253 AQEVAAMSQTNMFRPGIDVTQAVLLPQL----TW-RRQERSETVG-QWKAKVYDMHHVVVSVKSRkvpgamsddeffntc 326 Amborell...
7_pfamImport         62 EGDMAFRMNNPISTSYIDVDNIGFERTSrgflSWfTSPESTESVQ-GYECKVLSASNVHLVTKRR--------------- 125
EGT35741            219 PGAMEDRLNNTISTTYIDVDNIGFERTSrgflSWfTSGESNETVD-GYDCKVLNASNVHFVTKRR--------------- 282 Caenorha...
XP_003111624        219 PGAMDDRLRNPISTTYIDVDNIGFERTSrgflSWfTSGESNETVD-KYECKVLNASNVHLVTKRR--------------- 282 Caenorha...
CUT99623            162 NETVQTSLHMPLIRMHMDFTRLSCKKETsk-lPW-LKDNVPEKIG-PYNTQNYSINHVKISVKKR--------------- 223 Echinoco...
XP_002016389        284 EDEVDGLMSTDIMATQMSTKTINFARAQs---GWiFRANRKELIGgQYQCELYTIQGLIIKQRKR--------------- 345 Drosophi...
WGS:AAPU:GI20952-PA 279 EDEVDVLMSTDILATQMSTKTIQFARAQr---GWlFRANRKELIGgQYQCEIYTIQGLVLKQRKR--------------- 340 Drosophi...
Q7Q159              201 EDEVDILMSSDILAAQMSTKGISFTKAQs---GWiFREDRRETVAgQYDSDLYTINGLTLEQRKR--------------- 262 Anophele...
2_pfamImport         56 EDEVDVLMSSDILAAQMSTKKINFSRAQt---GWfFRADRKELVAgQYNSDLFTINGLVLKSRKR--------------- 117
XP_004226058        229 EEEVDISMSTDIVDAAMKTKESVIESVNs---GWiFTHHKAEKIG-QFNADFYRISNLMLVTRKR--------------- 289 vase tun...
XP_006854269        327 nendtesegyEDVLTEEEKKQ------------------LEMALKmgspengddgfsdm--vvshrhscyeqrdvFIEGG 386 Amborell...
7_pfamImport        126 ----------MDHLSANRRAE------------------LENNGKs-----------------------------IDTKA 148
EGT35741            283 ----------YDHLTREARDR------------------LAQEEA------------------------------SESKA 304 Caenorha...
XP_003111624        283 ----------YDHLSHEARER------------------LAQEEA------------------------------SESKA 304 Caenorha...
CUT99623            224 ----------SEHLTKEDVRF------------------LSTLH--------------------------------SHIK 243 Echinoco...
XP_002016389        346 ----------REHLSHEDLQKnraiiesmrssvvqpdgrRSSLNSqttdtttdsnnpaapngitlpelprrsslqAPPAS 415 Drosophi...
WGS:AAPU:GI20952-PA 341 ----------REHLSHEDLQKnraive-------titkgGNHTDSnaattpngsnlt-------lpelprrsslpPPPTT 396 Drosophi...
Q7Q159              263 ----------REHLSRDDLQKnkalme-------sltkgGQGQQGgidqngei---------------yrreslqPPPNC 310 Anophele...
2_pfamImport        118 ----------REHLSSDDLQKnkmlve-------sftkgSNSSSGsltpngslkne--------pyevsrrssliPPPET 172
XP_004226058        290 ----------REHLSEEDIKKnkm------------lrdAISKGEdagkildeced--------ssdperrqslpAPEPS 339 vase tun...
XP_006854269        387 EhsdgvscevkqEKKgwfghwgkrgvksneghpkkfapprssvcmdekvsdllgdstiqsrpgrhsvevgvrgdefrrvr 466 Amborell...
7_pfamImport        149 MaglkkfishtkTDEntkrnlleeglsaeqy------------------------------------------------- 179
EGT35741            305 VssfkkmmstnkTDEntkrdlfaegaitpdqy------------------------------------------------ 336 Caenorha...
XP_003111624        305 VasfkkmmstnkMDEnttrdlfaegltpdqy------------------------------------------------- 335 Caenorha...
CUT99623            244 QgtvnsavklvqDRAsavneetadgvklprltprv--------------------------------------------- 278 Echinoco...
XP_002016389        416 SvtwdqyleaavGRCprl-------------------------------------------------------------- 433 Drosophi...
WGS:AAPU:GI20952-PA 397 TvtwsqyieapvGKCpql-------------------------------------------------------------- 414 Drosophi...
Q7Q159              311 EvtwqdyvsaepGQYpnl-------------------------------------------------------------- 328 Anophele...
2_pfamImport        173 NvtwedyinaevGEMpsi-------------------------------------------------------------- 190
XP_004226058        340 KitwkqynnhrnSDpcl--------------------------------------------------------------- 356 vase tun...
XP_006854269        467 etkdgkkfastsesshkrvkdgNRESEYKKGLRPVLWLSPNFPLST-EELLPLLDILANKVKAIRRLRELLTT------K 539 Amborell...
7_pfamImport        180 ------fypqyefepksdigsaREVERKSTGFKATLWMADDYPLNLnDQIVPIVELMAVNSSHFARLHKFIRL------Q 247
EGT35741            337 ------ldpnyefepgcdigkaREVVKRSNAFKATLWMADEYPLSLhDQIIPIVELMAVNSPHFARLHNFIRL------Q 404 Caenorha...
XP_003111624        336 ------ldpnyefergcdigkkKEVVRRSNAFKATLWMADEYPLNLhDQIIPIVELMAVNSPHFARLHKFIRL------Q 403 Caenorha...
CUT99623            279 --twrtyrswklqdndlyigrkPVLKLQTNEMKLNVAMTNEIDFNI----TYLLDMF----KCFSPLRKFTKLdetilsS 348 Echinoco...
XP_002016389        434 -------------------grpLVNKQSSKTLRATVAMSTDFPLSV-EMLLDVLEVV-APLKHINKLRNFVTL------K 486 Drosophi...
WGS:AAPU:GI20952-PA 415 -------------------graPVNKQSNKTLRATVAMSTDFPLSV-DMLLDVLEVV-APLKHINKLREFVTL------K 467 Drosophi...
Q7Q159              329 -------------------greLVYKESSKNFKATVAMSKDFPLSV-DMLLNVLEVI-APFKHFSKLREFVTL------K 381 Anophele...
2_pfamImport        191 -------------------grkMVYKESSKHFKATVSMSTDFPLSI-EMLLNVLEVI-APFKQFTKLREFITL------K 243
XP_004226058        357 -------------------grhRKEKLNTKRFEASLGMSAEFPVRL-ENLLPIFAALGTKAKLFSKLKDFVTL------R 410 vase tun...
XP_006854269        540 LPPGtFPVKVAIPVVPTIRVIV-TFTKFEELQ-PLeefctppssplpgrlvgrespsisanysngswfqwikvpyrqgss 617 Amborell...
7_pfamImport        248 LPAG-FPIKIEIPLFHIVSARV-AFQNVNVAGkYVtpleg---------------------------------------- 285
EGT35741            405 LPAG-FPVKIEIPLFHIVSARI-AFQNVNSPGkHVipldd---------------------------------------- 442 Caenorha...
XP_003111624        404 LPAG-FPVKIEIPLFHIVSARI-AFQNVNTPGkYVtpidd---------------------------------------- 441 Caenorha...
CUT99623            349 LPPG-FPVRIDVPVSPGITGRV-TFKSVELCEgDKmtns----------------------------------------- 385 Echinoco...
XP_002016389        487 LPTG-FPVKIEIPVLHTVTAKV-TFQKFEFTNs----------------------------------------------- 517 Drosophi...
WGS:AAPU:GI20952-PA 468 LPTG-FPVKIEIPVLHTVTAKV-TFQKFEFRDn----------------------------------------------- 498 Drosophi...
Q7Q159              382 LPSG-FPVKIDIPILPTVSAKI-TFQKFEFRDd----------------------------------------------- 412 Anophele...
2_pfamImport        244 LPSG-FPVKIEIPILRTVSAKI-TFQRFDFQDn----------------------------------------------- 274
XP_004226058        411 LPSG-FPVRIDIPVFPTVKA-ViTFPQFEFRSs----------------------------------------------- 441 vase tun...
XP_006854269        618 ginspssrvedIQDPFAIPSDYT 640 Amborella trichopoda
7_pfamImport        286 ------nnvfiEDAAFQIPAGY- 301
EGT35741            443 -------svliEDEAFEIPQGYi 458 Caenorhabditis brenneri
XP_003111624        442 ------qnveiDENAFRIPGGYv 458 Caenorhabditis remanei
CUT99623            386 -------gfvlRDELFKIPMGYi 401 Echinococcus multilocularis
XP_002016389        518 ----------iPDKLFEIPSNYW 530 Drosophila persimilis
WGS:AAPU:GI20952-PA 499 ----------iPAKLFEIPAHYw 511 Drosophila mojavensis
Q7Q159              413 ----------iSPDLFVIPEDYK 425 Anopheles gambiae str. PEST
2_pfamImport        275 ----------iSEELFEVPSDY- 286
XP_004226058        442 ----------iPSSMFTVPSTYK 454 vase tunicate
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